Relationship between periodontal disease and C-reactive protein among adults in the atherosclerosis risk in communities study

Slade, Gary D.; Ghezzi, Elisa M.; Heiss, Gerardo; Beck, James D.; Riche, Estelle; Offenbacher, S.

doi:10.1016/j.accreview.2003.08.039

Cited by 130 publications

(176 citation statements)

References 27 publications

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“…Second, in the presence of obesity, periodontal disease may not be sufficient to enhance background CRP levels. A previous study among individuals in the Atherosclerosis Risk in Communities (ARIC) study demonstrated that at low BMI, periodontal disease is associated with CRP; at BMI levels Ͼ30 kg/m 2 , the association is attenuated markedly (39). Obesity may elicit an inflammatory re- sponse (40).…”

Section: Discussionmentioning

confidence: 99%

Severe Periodontitis Is Associated with Low Serum Albumin among Patients on Maintenance Hemodialysis Therapy

Kshirsagar

Craig

Beck

et al. 2007

Clinical Journal of the American Society of Nephrology

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The relationship between periodontitis and two measures of systemic inflammation, serum albumin and C-reactive protein (CRP), were examined among patients who were receiving chronic outpatient hemodialysis. Adult patients at two locations, North Carolina and New York City, were evaluated by dentist examiners. Six sites per tooth (up to 32 teeth per patient) were examined. A periodontitis case was defined as >60% of sites with attachment level >4 mm. Multivariable logistic regression was used to determine the association of periodontitis with low serum albumin, defined as <3.5 mg/dl, and with high CRP, defined as >3.0 mg/dl. A total of 154 patients completed the study. The mean age was 54.6 yr (SD 13.3), and average duration of dialysis was 4.0 yr (3 mo to 16 yr). Eighty-six (54.6%) were men, and 89 (58.2%) were black. Common causes of end-stage kidney disease were hypertension (12.3%), diabetes (22.1%), glomerulonephritis (7.1%), and other (58.4%). The average number of teeth was 20.3 (SD 8.4). Thirty-five (23%) patients were periodontitis cases. Severe periodontitis was associated with low serum albumin (odds ratio 8.20; 95% confidence interval 1.61 to 41.82; P ‫؍‬ 0.01) compared with individuals without severe periodontitis disease after adjustment for age, gender, race, diabetes, hypertension, body mass index, smoking, study site, total cholesterol, serum calcium, serum phosphorus, and normalized protein catabolic rate. There was no observed association of severe periodontitis with CRP. Investigation of the potential contribution of periodontitis to serum albumin and possibly to morbidity and mortality among patients with end-stage kidney disease seems warranted.

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Section: Discussionmentioning

confidence: 99%

Severe Periodontitis Is Associated with Low Serum Albumin among Patients on Maintenance Hemodialysis Therapy

Kshirsagar

Craig

Beck

et al. 2007

Clinical Journal of the American Society of Nephrology

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“…15 It is plausible that the elevated CRP among edentulous subjects might be attributable to the increased level of AGEs, in addition to the possibility of previous oral infection. 26 Furthermore, edentulism was associated with lower intake of fruits and vegetables that are beneficial for cardiac health. 27 Taken together, this evidence suggests that oral health may impact on the development of diabetes and CVD via 2 pathways-through diet and oral infection.…”

Section: Carbohydrate Metabolism Endothelial Dysfunction and T2dmmentioning

confidence: 99%

Oral infection, hyperglycemia, and endothelial dysfunction

Janket

Jones

Meurman

et al. 2008

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, an

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“…de citocinas, proteínas de fase aguda y factores proinflamatorios y procoagulantes que aumentan el riesgo cardiovascular (6)(7)(8)(9).…”

Section: Introductionunclassified

Proteína amiloide A sérica como marcador de inflamación sistémica en pacientes con enfermedad periodontal

Romero-Sánchez

Uribe-Rivera

Velandia-Quintero

et al. 2013

Avances en Periodoncia

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RESUMENLa respuesta de fase aguda es la reacción inflamatoria inmediata del huésped que contrarresta desafíos como lesión de los tejidos, infección y trauma. Los reactantes de fase aguda que han recibido mayor atención son: proteína C reactiva (PCR), componente sérico P, proteína amiloide sérica (AAS) y alfa 1 ácido glicoproteína. Se ha establecido en décadas pasadas que las proteínas de fase aguda no solamente aparecen en procesos de enfermedades severas y agudas si no también en condiciones crónicas. El AAS es el principal componente de las placas amiloideas secundarias depositadas en los órga-nos principales como consecuencia de la enfermedad inflamatoria crónica. La familia de la AAS contiene un número de diferentes apolipoproteínas expresadas, las cuales son sintetizadas principalmente por el hígado. El aumento de AAS es considerado un marcador sistémico de enfermedades inflamatorias agudas y enfermedades crónicas que afecta la composición y función de lipoproteínas de alta densidad (HDL). Se ha demostrado que la intervención terapéutica en la periodontitis disminuye la inflamación y reduce el AAS significativamente y por consiguiente puede reducir el riesgo de enfermedad cardiovascular (ECV). Además es posible que pacientes con periodontitis, que presentan un aumento de la PCR y el AAS, representen un subgrupo específico en términos de riesgo para la aterosclerosis y enfermedad cardiovascular en comparación a los pacientes con periodontitis cuyos niveles plasmáticos de AAS son normales, estableciendo así una relación directa entre la enfermedad periodontal y los niveles de AAS.

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Relationship between periodontal disease and C-reactive protein among adults in the atherosclerosis risk in communities study

Cited by 130 publications

References 27 publications

Severe Periodontitis Is Associated with Low Serum Albumin among Patients on Maintenance Hemodialysis Therapy

Severe Periodontitis Is Associated with Low Serum Albumin among Patients on Maintenance Hemodialysis Therapy

Oral infection, hyperglycemia, and endothelial dysfunction

Proteína amiloide A sérica como marcador de inflamación sistémica en pacientes con enfermedad periodontal

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