Relationship between periodontal outcomes and serum biomarkers changes after non-surgical periodontal therapy

Lobão, Walder J M; Carvalho, Rosana Costa Casanovas de; Leite, Sandra Augusta Moura; Rodrigues, Vandílson Pinheiro; Batista, José Eduardo; Filho, Isaac Suzart Gomes; Pereira, António Luis

doi:10.1590/0001-3765201920170652

Cited by 12 publications

(3 citation statements)

References 20 publications

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“…Among the periodontal parameters assessed, the mean modified gingival index was reduced from day 0 to day 90 in group III and group II following scaling and root planing, which was statistically significant ( Table 1 , p = 0.000). These results are in accordance with earlier observations reported by Labao et al and Kim et al who found a reduction in inflammation following non-surgical therapy [ 19 , 20 ]. In intragroup and intergroup comparisons, we found the mean probing pocket depth (PPD) was significantly reduced from day 0 to 90 in group III and group II ( p = 0.000).…”

Section: Discussionsupporting

confidence: 94%

Salivary Biomarkers in Periodontitis Post Scaling and Root Planing

Priya

Mahendra

et al. 2022

JCM

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Objectives: This study was conducted to evaluate the levels of salivary uric acid and arginase in patients with periodontitis, generalized gingivitis, and in healthy individuals. Then, the effects of non-surgical periodontal therapy on levels of salivary arginase and uric acid were also investigated. Methods: A total of 60 subjects were divided into three groups based on periodontal health: group I comprised 20 healthy individuals; group II comprised 20 subjects who had generalized gingivitis; group III comprised 20 subjects who had generalized periodontitis. On day 0, the clinical examination of periodontal status was recorded, following which saliva samples were collected. Group II and group III subjects underwent non-surgical periodontal therapy. These patients were recalled on day 30 to collect saliva samples. The periodontal parameters were reassessed on day 90, and saliva samples were collected for analysis of salivary arginase and uric acid levels. Results: Group II and group III showed improvement in clinical parameters following non-surgical periodontal therapy on the 90th day. The MGI score, PPD, and CAL showed improvement. On day 0, at baseline, salivary arginase levels in group III and group II were higher than those in healthy subjects, whereas on day 0, salivary uric acid levels in group III and group II were lower than those in healthy subjects. Both on day 0 and day 90, the salivary arginase level showed a positive correlation with the periodontal parameters, whereas the salivary uric acid level was positively correlated with the periodontal parameters on day 90. Conclusion: the level of salivary arginase was a pro-inflammatory marker and a raised level of salivary uric acid was an anti-inflammatory marker following periodontal therapy, suggesting their pivotal role in assessing periodontal status and evaluation of treatment outcome.

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Section: Discussionsupporting

confidence: 94%

Salivary Biomarkers in Periodontitis Post Scaling and Root Planing

Priya

Mahendra

et al. 2022

JCM

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“…The systematic review identified 37 case-control studies [14][15][16][18][19][20][21] and 8 intervention studies [67][68][69][70][71][72][73][74] from fifteen different countries, across Asia, Europe and America (Appendices S3). A total of 11,368 participants were included in this review.…”

Section: Studies Characteristicsmentioning

confidence: 99%

Periodontitis and circulating blood cell profiles: a systematic review and meta-analysis

Botelho

Machado

Hussain

et al. 2021

Experimental Hematology

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Background: Periodontitis is a chronic inflammatory disease with local and systemic implications. Evidence suggests consistent hematologic changes associated with periodontitis. Our aim was to critically appraise the available evidence on hemogram, leukogram and thrombogram alterations in otherwise healthy patients suffering from periodontitis when compared to controls. Methods: For this systematic review (SR), we searched MEDLINE, Web of Science, EMBASE and The Cochrane Library (CENTRAL) for studies published up to June 2020. Both observational and interventional studies with baseline standard hematologic levels were included. Outcomes of interest were baseline hemogram, leukogram and thrombogram values and the impact of periodontitis treatment on these outcomes. Upon risk of bias assessment, data extraction both qualitative and quantitative (standardised mean differences MD) analyses were performed. Random-effects meta-analyses were performed to provide pooled estimates. PRISMA guidelines were followed (PROSPERO reg: CRD42020164531).Findings: A total of 45 studies, 8 intervention and 37 case-control, were identified after the final search of 3012 titles. Following quality assessment, 43 articles were deemed as of low risk of bias whilst two manuscripts with moderate risk. Meta-analyses confirmed that periodontitis was associated with both white and red cells lineages. Severe chronic periodontitis was associated with greater White Blood Cells count (WBC) (SMD of 0.53, 95% CI 0.26-0.79) when compared to controls. Patients with periodontitis were associated with higher number of neutrophils (MD of 7.16%, 95% CI: 5.96-8.37) and lower Mean Platelet Volume (MD of 0.30 fL, 95% CI: 0.49 --0.10) than healthy participants. Nonsurgical periodontal treatment (NSPT) was associated with a decrease in WBC levels (WMD of 0.28 10 9 /L, 95% CI -0.47 --0.08) in patients suffering from chronic periodontitis.Interpretation: Periodontitis is associated with hematologic changes (SORT A recommendation). Higher WBC, neutrophils, erythrocyte sedimentation rate and lower MPV levels are the most common blood counts findings. The association between periodontitis and WBC could be causal in nature. Further research in assessing whether periodontitis causes circulating blood cells changes and identify the molecular mechanisms behind these associations are warranted.

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“…MILLER e KRANGEL, 1991;LOBÃO et al, 2019). As proteínas inflamatórias que são produzidas durante as respostas inflamatórias têm sido associadas ao início ou progressão do dano tecidual(SEYMOUR e GEMMELL, 2001; HANADA e YOSHIMURA, 2002).…”

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Terapia fotodinâmica antimicrobiana para biomodificação radicular em procedimentos regenerativos de lesões de furca classe II: ensaio clínico randomizado de 12 meses

Valle¹

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p>0,01). Quanto ao questionário da escala VAS, observou-se no GC quanto maior o %ff_6, maior DD_6 (p<0,05); no teste, quanto maior a PHF_0, menores as queixas com E e CM (p<0,05). O questionário OHIP-14 mostrou correlações no GC e no GT, principalmente em 12 meses mostrando que quanto maior a PHF, menor a satisfação dos pacientes com a saúde bucal (p<0,01 e p<0,05). Estes resultados sugerem que a terapia fotodinâmica antimicrobiana não exerce nenhuma influência em tratamentos de regeneração tecidual guiada em lesões de furca classe II. Mas procedimentos regenerativos combinados com uso de Bio-Oss ® e Bio-Gide ® são efetivos no tratamento de lesões de furca classe II.

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Relationship between periodontal outcomes and serum biomarkers changes after non-surgical periodontal therapy

Cited by 12 publications

References 20 publications

Salivary Biomarkers in Periodontitis Post Scaling and Root Planing

Salivary Biomarkers in Periodontitis Post Scaling and Root Planing

Periodontitis and circulating blood cell profiles: a systematic review and meta-analysis

Terapia fotodinâmica antimicrobiana para biomodificação radicular em procedimentos regenerativos de lesões de furca classe II: ensaio clínico randomizado de 12 meses

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