Relationship Between Plasma Carotenoids, Fruit and Vegetable Intake, and Plasma Extracellular Superoxide Dismutase Activity in Women: Different in Health and Disease?

Zheng, Jinjin; Rautiainen, Susanne; Morgenstern, Ralf; Wolk, Alicja

doi:10.1089/ars.2010.3633

Cited by 8 publications

(6 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…33 Recently, lower circulating EC-SOD in healthy women with higher plasma antioxidant carotenoids and fruit and vegetable intake was observed but in the women with history of diabetes there was no such association. 34 Higher serum MDA in our subjects with diabetes confirms other reports. 6 Disappearance of difference in serum MDA between subjects with and without diabetes after controlling for FPG indicates the role of glyco-oxidation pathway in lipid peroxidation.…”

Section: Discussionsupporting

confidence: 92%

Evidence for augmented oxidative stress in the subjects with type 1 diabetes and their siblings: a possible preventive role for antioxidants

Neyestani

Ghandchi

et al. 2012

Eur J Clin Nutr

View full text Add to dashboard Cite

BACKGROUND/OBJECTIVES: Oxidative stress (OS) is thought to be involved in both development of type 1 diabetes (T1D) and its further complications. In this study, certain biomarkers of OS were compared among the subjects with T1D, their non-diabetic siblings and unrelated healthy controls. SUBJECTS/METHODS: Known cases of T1D from both sexes aged 5-25 years were enrolled in a case-control study (n 1 ¼ 60). There were two control groups; non-diabetic siblings (n 2 ¼ 60) and unrelated apparently healthy subjects (n 3 ¼ 60). Anthropometric, dietary and laboratory assessments were done. RESULTS: There was no significant difference in dietary data among the groups. Total antioxidant capacity was significantly lower in T1D than both related and unrelated controls (1.6±0.05, 1.7±0.05 and 1.8±0.06 mmol BSA equivalent/l, respectively, P ¼ 0.044). Both T1D subjects and their siblings showed lower glutathione peroxidase (GSH-px) levels (median (interquartile range): 22.2 (28.6), 29.9 (23) and 41.8 (73.6) U/ml, respectively, P ¼ 0.006). On the contrary, superoxide dismutase concentrations were significantly higher in T1D group and the siblings than unrelated healthy controls (243 (45.3), 157.8 (176.9) and 27.9 (8.7) U/l, respectively, Po0.001). Serum concentrations of GSH correlated with energy intake in the siblings (r ¼ 0.521, Po0.001) and unrelated controls (r ¼ 0.268, P ¼ 0.042) but not in T1D group. The associations remained significant after controlling for blood glucose (r ¼ 0.437, P ¼ 0.001 and r ¼ 0.420, P ¼ 0.011, respectively) in both the groups. CONCLUSION: Augmented OS in the siblings may indicate an increased requirement for antioxidants in genetically diabetes-prone subjects.

show abstract

Section: Discussionsupporting

confidence: 92%

Evidence for augmented oxidative stress in the subjects with type 1 diabetes and their siblings: a possible preventive role for antioxidants

Neyestani

Ghandchi

et al. 2012

Eur J Clin Nutr

View full text Add to dashboard Cite

show abstract

“…Although other 'unknown' bioactive compounds present in foods might act synergistically in protecting the lungs from oxidative stress Romieu and Trenga, 2001;Kan et al, 2008), the influence of the total antioxidant network on pulmonary function has not previously been investigated. TAC might be related to both exogenous and endogenous antioxidant defenses (Zheng et al, 2011;Pitsavos et al, 2005), further strengthening the hypothesis of a crucial role of redox molecules in improving respiratory health. Associations were statistically significant, independently from confounding factors, in women only, while in men they were lost after adjustment for confounding.…”

Section: Discussionmentioning

confidence: 62%

Total dietary antioxidant capacity and lung function in an Italian population: a favorable role in premenopausal/never smoker women

et al. 2011

View full text Add to dashboard Cite

Background/Objectives: Antioxidant-rich foods may favorably influence lung function. We examined possible associations between the total dietary antioxidant capacity (TAC) and pulmonary function in a healthy Italian population. Subjects/Methods: Until May 2009, 22 300 persons were randomly recruited from the general population in the Moli-sani project. A sample only including healthy women (5824) and men (5848) was analyzed. TAC was measured in foods by three different assays and the ferric reducing-antioxidant power (FRAP) assay was selected as the better indicator of dietary TAC. The European Investigation into Cancer and Nutrition Food Frequency Questionnaire was used for dietary assessment. The association between quintiles of dietary FRAP and pulmonary indexes was assessed using analysis of variance separately for men and women. Results: After adjustment for confounders, women in the highest quintile of FRAP intake had þ 39 ml forced expiratory volume in the first second (FEV 1 ) and þ 54 ml forced vital capacity, compared with those in the lowest quintile (P for trend p0.006). Stratified analysis showed that this relationship only occurred in women who were premenopausal/never smokers. In this subgroup, the observed effect of higher FRAP intake on FEV 1 was equivalent to an improvement in pulmonary age of 3.3 years. In men, all significant associations between pulmonary function and TAC were lost after adjustment for confounding. Conclusions: Dietary TAC may have a favorable role in respiratory health, particularly in premenopausal/never smoker women.

show abstract

“…The various carotenoids in these foods are believed to be responsible for their antioxidant properties and may be involved in the prevention of chronic diseases. [ 37 38 39 ] These findings suggest that the majority of plasma carotenoids are lowered immediately after an ischemic stroke, perhaps as a result of increased oxidative stress, as indicated by a concomitant rise in malondialdehyde concentrations. [ 28 ]…”

Section: Discussionmentioning

confidence: 99%

Carotenoids as potential antioxidant agents in stroke prevention: A systematic review

et al. 2017

View full text Add to dashboard Cite

Stroke and other cerebrovascular diseases are among the most common causes of death worldwide. Prevention of modifiable risk factors is a cost-effective approach to decrease the risk of stroke. Oxidative stress is regarded as the major flexible operative agent in ischemic brain damage. This review presents recent scientific advances in understanding the role of carotenoids as antioxidants in lowering stroke risk based on observational studies. We searched Medline using the following terms: (Carotenoids [MeSH] OR Carotenes [tiab] OR Carotene [tiab] OR “lycopene [Supplementary Concept]” [MeSH] OR lycopene [tiab] OR beta-Carotene [tiab]) AND (stroke [MeSH] OR stroke [tiab] OR “Cerebrovascular Accident” [tiab] OR “Cerebrovascular Apoplexy” [tiab] OR “Brain Vascular Accident” [tiab] OR “Cerebrovascular Stroke” [tiab]) AND (“oxidative stress” [MeSH] OR “oxidative stress”[tiab]). This search considered papers that had been published between 2000 and 2017. Recent studies indicated that high dietary intake of six main carotenoids (i.e., lycopene, <- and®-carotene, lutein, zeaxanthin, and astaxanthin) was associated with reduced risk of stroke and other cardiovascular outcomes. However, the main mechanism of the action of these nutrients was not identified, and multiple mechanisms except antioxidant activity were suggested to be involved in the observed beneficial effects. The dietary intake of six major carotenoids should be promoted as this may have a substantial positive effect on stroke prevention and stroke mortality reduction.

show abstract

Relationship Between Plasma Carotenoids, Fruit and Vegetable Intake, and Plasma Extracellular Superoxide Dismutase Activity in Women: Different in Health and Disease?

Cited by 8 publications

References 26 publications

Evidence for augmented oxidative stress in the subjects with type 1 diabetes and their siblings: a possible preventive role for antioxidants

Evidence for augmented oxidative stress in the subjects with type 1 diabetes and their siblings: a possible preventive role for antioxidants

Total dietary antioxidant capacity and lung function in an Italian population: a favorable role in premenopausal/never smoker women

Carotenoids as potential antioxidant agents in stroke prevention: A systematic review

Contact Info

Product

Resources

About