Relationship between plasma D-dimer levels and clinicopathologic parameters in resectable colorectal cancer patients

Xu, Gang; Zhang, Yali; Huang, Weiya

doi:10.3748/wjg.v10.i6.922

Cited by 25 publications

(16 citation statements)

References 17 publications

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“…[15] D-dimer levels found in our study were found to be close to the values found in the study by Dirix et al [9] and D-dimer levels in our study were higher than the levels found in studies done by Suega et al, [18] Ay et al [3] and Benoy et al [19] ( Table 2) In our study, mean plasma D-dimer levels were significantly higher in patients before surgery as compared to levels after surgery. This observation is similar to the findings of Xu G et al [20] who did a study on operable colorectal carcinoma patients, wherein it was observed that D-dimer levels were remarkably elevated pre-operatively and after surgery the D-dimer levels began to descend stepwise and after 2 weeks almost returned to control level. [20] This could be due to decrease in tumour burden following surgery.…”

Section: Discussionsupporting

confidence: 80%

“…This observation is similar to the findings of Xu G et al [20] who did a study on operable colorectal carcinoma patients, wherein it was observed that D-dimer levels were remarkably elevated pre-operatively and after surgery the D-dimer levels began to descend stepwise and after 2 weeks almost returned to control level. [20] This could be due to decrease in tumour burden following surgery.…”

Section: Discussionsupporting

confidence: 80%

“…This was similar to the findings by Batschauer et al, [1] Dirix et al [9] and Ahmed et al [5] In our study, we found a positive correlation between lymph node involvement and D-dimer levels. This was similar to the findings of Blackwell et al, [4] Kwon et al [21], Liu et al [10] and Xu G et al [20]. However, Batschauer et al [1] and Oya et al [8] found no significant association between lymph node positivity and D-dimer levels.…”

Section: Discussionsupporting

confidence: 77%

“…Xu G et al [20] 57 Yes Present study 63 Yes www.pacificejournals.com/apalm eISSN: 2349-6983; pISSN: 2394-6466…”

Section: Resultsmentioning

confidence: 99%

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D-Dimer Levels In Breast Carcinoma: A Clinico-Pathologic Study

Patel

Rashmi

Harish

2018

APALM

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Background: Breast cancer is the most common cause of death in women by neoplasia. Plasma D-dimer is a hypercoagulability and fibrinolytic system marker, which is produced when factor XIIIa (a cross-linked fibrin) is degraded by plasmin. It is increased in various solid tumour patients including breast, lung, prostate, cervical and colorectal cancers.Methods: 30 patients of breast carcinoma who underwent radical mastectomy (cases) and 30 cases without carcinoma (controls) were included. The baseline parameters (D-dimer levels) were measured in both cases and controls. From each patient, whole blood was collected and Quantitative D-dimer levels were obtained by Diazyme's D-dimer Assay using the instrument, RANDOX Rx imola. Other parameters such as histopathological features, hormonal receptors (ER & PR) and HER2/neu status were studied in cases.Result: Mean plasma D-dimer levels were significantly higher in patients with breast carcinoma before surgery as compared to after surgery (p<0.001). Quantitative D-dimer levels highly correlated with lymph node status and histopathological grading (p=0.003, p=0.015 respectively). Conclusion:Our study showed that high plasma D-dimer levels can be used as a marker for lymph node involvement and higher histopathological grade. Due to the ease with which plasma D-dimer levels can be obtained and its cost effectiveness, quantitative D-dimer levels can be added to models for predicting axillary lymph node involvement.

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Section: Discussionsupporting

confidence: 80%

Section: Discussionsupporting

confidence: 80%

Section: Discussionsupporting

confidence: 77%

“…Xu G et al [20] 57 Yes Present study 63 Yes www.pacificejournals.com/apalm eISSN: 2349-6983; pISSN: 2394-6466…”

Section: Resultsmentioning

confidence: 99%

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D-Dimer Levels In Breast Carcinoma: A Clinico-Pathologic Study

Patel

Rashmi

Harish

2018

APALM

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“…[16,17] Subsequent studies have confirmed these findings. [18,19] Because the formation of deep vein thrombosis may affect the prognosis of patients, Stender et al further designed a prospective cohort study to eliminate the effect of this factor. [3] The results suggested that for colorectal cancer patients without deep vein thrombosis pre-or post-operatively, the 1-year survival rate of patients with preoperative plasma D-dimer levels above 0.3 mg/L was 78.1%.…”

Section: Discussionmentioning

confidence: 99%

High levels of D-dimer correlated with disease status and poor prognosis of inoperable metastatic colorectal cancer patients treated with bevacizumab

Zhu¹,

Liu²,

Zhao³

et al. 2014

J Can Res Ther

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Significance of preoperative blood tests in the prognosis of colorectal cancer: A prospective, multicenter study from Hungary

Biró

Kolozsi

Nagy

et al. 2021

Clinical Laboratory Analysis

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Background The focus of this study was to analyze the prognostic value of different combinations of inflammatory and coagulation factors using preoperative blood and to appraise the clinical importance of these biomarkers in colorectal cancer patients. Methods A prospective, multicenter study included patients undergoing radical colorectal surgery in three county hospitals. Inflammatory and coagulation markers were analyzed preoperatively. Results Two hundred and one patients were included. We examined patients based on their tumor localization. Colon cancer group involved patients with the tumor localized in the colon (n = 105, 52.24%) and rectal cancer group the patients with the tumor in the rectum (n = 96, 47.76%). Examining coagulation factors, univariate Cox analysis of colon cancer patients showed that activated partial thromboplastin time (p = 0.020) was significantly associated with overall survival, but we could not prove it in multivariate analysis. In colon cancer patients, neutrophil‐to‐lymphocyte ratio (NLR, p < 0.001) was positively correlated with tumor size and had significant association (χ2 = 5.48, p = 0.019, df = 1) with perineural invasion. Univariate and multivariate Cox analysis of colon cancer patients showed that NLR (p = 0.011 and p = 0.048) was significantly associated with disease‐free survival (DFS). Conclusion NLR was proved to be an independent prognostic factor for DFS in patients with non‐metastatic colon cancer. NLR might help to recognize the high‐risk patients between patients with the same tumor‐node‐metastasis stage and could help with the decision on adjuvant chemotherapy. Since the biomarkers in preoperative blood tests are habitually evaluated, NLR could be an inexpensive prognostic marker that can be easily assessed in clinical practice.

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Relationship between plasma D-dimer levels and clinicopathologic parameters in resectable colorectal cancer patients

Cited by 25 publications

References 17 publications

D-Dimer Levels In Breast Carcinoma: A Clinico-Pathologic Study

D-Dimer Levels In Breast Carcinoma: A Clinico-Pathologic Study

High levels of D-dimer correlated with disease status and poor prognosis of inoperable metastatic colorectal cancer patients treated with bevacizumab

Significance of preoperative blood tests in the prognosis of colorectal cancer: A prospective, multicenter study from Hungary

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