Relationship between PTH, sex steroid and bone turnover marker measurements and bone density in recently postmenopausal women

Garcı́a-Pérez, Miguel A.; Moreno-Mercer, J.; Tarı́n, Juan J.; Cano, Antonio

doi:10.1016/s0378-5122(03)00084-7

Cited by 21 publications

(9 citation statements)

References 42 publications

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“…This absence of such associations is consistent with a cross-sectional study that found no relationship between BMD and total testosterone in early postmenopausal women (37). In contrast, however, a longitudinal study of women followed for 2-8 yr reported that bone loss was associated with lower androgen concentrations (11).…”

Section: Discussionsupporting

confidence: 84%

Hormone Predictors of Bone Mineral Density Changes during the Menopausal Transition

Sowers

Jannausch

McConnell

et al. 2006

The Journal of Clinical Endocrinology & Metabolism

225

187

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Section: Discussionsupporting

confidence: 84%

Hormone Predictors of Bone Mineral Density Changes during the Menopausal Transition

Sowers

Jannausch

McConnell

et al. 2006

The Journal of Clinical Endocrinology & Metabolism

225

187

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“…Several studies found no difference in serum testosterone levels between osteoporotic and non-osteoporotic postmenopausal women, supporting the findings of the present study (14)(15)(16)(17). In other studies, no difference was found in serum testosterone levels in groups with or without fractures (18)(19)(20), testosterone did not protect bone mass (21) and not reduce fracture risk (22).…”

Section: Discussionsupporting

confidence: 87%

Serum testosterone does not affect bone mineral density in postmenopausal women

Arpacı

Sağlam

Cuhaci

et al. 2015

Arch. Endocrinol. Metab.

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Objective: The purpose of the present study was to investigate the correlation between serum testosterone levels and bone mineral density (BMD) in postmenopausal women. Materials and methods: The study group was made up of postmenopausal women admitted to our tertiary center. Serum calcium, phosphorus, albumin, parathyroid hormone (PTH), thyrotropin (TSH), 25-OH vitamin D, and total testosterone concentrations were measured. Subjects were categorized into three groups regarding bone mineral density (BMD) values: normal (n = 22), osteopenia (n = 21), and osteoporosis (n = 21). Subjects were also categorized into three groups according to serum testosterone levels: low testosterone (n = 10), normal testosterone (n = 42), and high testosterone (n = 12). Results: No significant difference was found for serum testosterone, TSH, calcium, phosphorus, albumin, PTH, and 25-hydroxyvitamin D levels among patients with normal BMD, osteopenia, and osteoporosis (p > 0.05). Lumbar spine, total femur, femoral neck, trochanteric, intertrochanteric, and Ward's triangle BMD values were similar for the different testosterone levels (p > 0.05). Conclusion: There was no correlation between serum testosterone levels and patient age, body-mass index, or any measured BMD values. Given the findings in our study, which failed to demonstrate a statistically significant relationship between testosterone and BMD, adjustment of other risk factors for osteoporosis might have a more distinctive effect in this setting. Arch Endocrinol Metab. 2015;59(4):292-6

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“…The decline in both hormones may contribute to the favorable long-term effect of surgery on the risk of breast cancer [19,20] . However, the positive health effect may occur at the expense of an increased risk of osteoporosis and decreased sexual desire [21][22][23] . In summary, prophylactic oophorectomy may protect against breast cancer risk, not only through lowered estradiol but also through lowered testosterone levels after surgery.…”

Section: Discussionmentioning

confidence: 99%

Estradiol and Testosterone Levels Are Lower after Oophorectomy than after Natural Menopause

Korse¹,

Bonfrèr²,

Beurden³

et al. 2009

Tumor Biol

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Objective: The aim of this study was to compare hormone levels between women who became postmenopausal after a prophylactic bilateral salpingo-oophorectomy, and women who became postmenopausal in a natural way. Methods: In this cross-sectional study, we investigated estradiol, testosterone, SHBG, IGF-1 and IGFBP-3 levels in 35 surgically and 40 naturally postmenopausal women. Results: Serum samples were drawn at a mean age of 45.9 years for women with surgical menopause and at 56.5 years for women with natural menopause. Mean estradiol levels declined 1.4 pmol/l per year in both menopausal groups, however, at an 11.1 pmol/l lower level for women with surgical menopause. Testosterone levels of naturally postmenopausal women remained stable at a level of 0.89 nmol/l, while testosterone levels of the surgically postmenopausal women declined 0.04 nmol/l per year. Conclusions: For IGF-1, IGFBP-3 and SHBG, no differences were found between surgically and naturally postmenopausal women. Lower estradiol levels of surgically as compared to naturally postmenopausal women seem to be fully explained by the earlier onset of menopause in combination with the same age-related decrease. However, a decrease in testosterone levels seems to occur in oophorectomized women only, suggesting postmenopausal activity of ovaries in situ.

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Relationship between PTH, sex steroid and bone turnover marker measurements and bone density in recently postmenopausal women

Cited by 21 publications

References 42 publications

Hormone Predictors of Bone Mineral Density Changes during the Menopausal Transition

Hormone Predictors of Bone Mineral Density Changes during the Menopausal Transition

Serum testosterone does not affect bone mineral density in postmenopausal women

Estradiol and Testosterone Levels Are Lower after Oophorectomy than after Natural Menopause

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