Relationship between quantitative assessments of salivary buffering capacity and ion activity product for hydroxyapatite in relation to cariogenic potential

Aiuchi, H; Kitasako, Yuichi; Fukuda, Yasushi; Nakashima, Shinsuke; Burrow, MF; Tagami, Junji

doi:10.1111/j.1834-7819.2008.00027.x

Cited by 20 publications

(9 citation statements)

References 20 publications

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“…For this, they were asked to continually chew a 5 cm Â 5 cm piece of Parafilm Ò [25,26,45,46] and repeat the donations following this stimulation. Stimulation was controlled by regulating the size of the piece of Parafilm Ò , and the same volume of saliva was collected each time.…”

Section: Saliva Collection and Flow Ratementioning

confidence: 99%

Characterisation of human saliva as a platform for oral dissolution medium development

Gittings

Turnbull

Henry

et al. 2015

European Journal of Pharmaceutics and Biopharmaceutics

134

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Human saliva is a biological fluid of great importance in the field of dissolution testing. However, until now, no consensus has been reached on its key characteristics relevant to dissolution testing. As a result, it is difficult to select or develop an in vitro dissolution medium to best represent human saliva. In this study, the pH, buffer capacity, surface tension, viscosity and flow rate of both unstimulated (US) and stimulated (SS) human saliva were investigated in order to provide a platform of reference for future dissolution studies using simulated salivary fluids. Age and gender related differences in a sample size of 30 participants for each parameter were investigated. Significant differences were established between US and SS for all characteristics except surface tension. Therefore, the requirement for using two simulated salivary fluids should be considered when developing an oral dissolution model.

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Section: Saliva Collection and Flow Ratementioning

confidence: 99%

Characterisation of human saliva as a platform for oral dissolution medium development

Gittings

Turnbull

Henry

et al. 2015

European Journal of Pharmaceutics and Biopharmaceutics

134

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“…Tetapi biopolimer bermuatan negatif hanya dapat diabsorpsi melalui ion divalent bermuatan positif. 5,6 Walaupun gigi memiliki sistem selfcleansing dari aktivitas rongga mulut, gigi tetap dapat dilapisi endapan kalsium fosfat, meski hanya berupa lapisan tipis. 7 Karang gigi dapat men pada beberapa penyakit 8 , seperti penyakit jantung 9 , menopaus 10 , dan penyakit oral lainnya.…”

Section: Pendahuluanunclassified

Analysis of Calsium of Saliva and Relationship with the Calculus Formation

Kuswandani¹

2016

IJPST

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Kalsium dan fosfat di dalam saliva penting dalam proses remineralisasi email dan berperan juga dalam pembentukan karang gigi. Penelitian ini bertujuan untuk mengetahui hubungan antara kadar kalsium saliva dengan pembentukan karang gigi. Sampel dilarutkan dalam larutan lanthanum (III) klorida konsentrasi tinggi yang berfungsi untuk mengikat ion-ion pengganggu. Kadar kalsium di dalam saliva dianalisis dengan Spektroskopi Serapan Atom Nyala. Hasil penelitian menunjukkan bahwa kadar kalsium saliva adalah 56,84 ppm sampai 121,91 ppm. Sampel dari kelompok studi memiliki kadar kalsium rata-rata 95,34 dan sampel dari kelompok pembanding memiliki kadar kalsium rata-rata 78,13 ppm. Dari hasil penelitian dapat disimpulkan bahwa sampel dari kelompok studi memiliki kadar kalsium lebih besar dari pada sampel dari kelompok pembanding, yang berarti bahwa semakin besar kadar kalsium dalam saliva akan semakin mudah seseorang terkena karang gigi.

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“…The buffering capacity of human saliva plays a major role in countering pH fluctuations. Particularly, bicarbonates in saliva play a great role in elevating low oral pH after meals [2]. Various salivary components also demonstrate antibacterial capability: the iron-binding protein lactoferrin has been shown to inhibit aerobic and facultative anaerobic bacteria (such as Streptococcus mutans ) which require iron to metabolize.…”

Section: Introductionmentioning

confidence: 99%

In Vivo Release Kinetics and Antibacterial Activity of Novel Polyphenols-Enriched Chewing Gums

et al. 2016

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Chewing gums may be particularly effective means for delivering and maintaining bioactive molecules, included in the gum formulation, able to have an anti-cariogenic effect. The purposes of this study were: to develop novel chewing gums containing quercetin (Qt); to evaluate their release using in vivo trial; finally, to test their in vivo antibacterial effect against oral Streptococcus mutans strains. A preliminary study was performed to produce new gums, enriched with the polyphenol quercetin. Then, a first in vivo experimental study was assessed to test the percentages of Qt released in the saliva of young volunteers. Moreover, a second clinical trial was performed to analyze the antibacterial capability of these enriched chewing gums against S. mutans strains after 14 days of daily consumption. The release analysis showed that a more effective release of Qt occurs in the first minutes of chewing, and it does not change saliva pH values. Moreover, Qt included in gums demonstrates an effective antibacterial activity, showing a reduction of the concentration of S. mutans strains in saliva samples, especially after 7 days. Qt included in experimental chewing gums could be efficiently released into the oral cavity and could promote an effective anti-caries concentration in volunteer's saliva, without changing salivary pH values.

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Relationship between quantitative assessments of salivary buffering capacity and ion activity product for hydroxyapatite in relation to cariogenic potential

Cited by 20 publications

References 20 publications

Characterisation of human saliva as a platform for oral dissolution medium development

Characterisation of human saliva as a platform for oral dissolution medium development

Analysis of Calsium of Saliva and Relationship with the Calculus Formation

In Vivo Release Kinetics and Antibacterial Activity of Novel Polyphenols-Enriched Chewing Gums

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