Relationship Between Red Cell Distribution Width and Stroke in Patients With Stable Chronic Heart Failure

Kaya, Ahmet; Işık, Turgay; Kaya, Yasemın; Enginyurt, Özgür; Günaydın, Zeki Yüksel; İşcanlı, Murat Doğan; Kurt, Mustafa; Tanboğa, İbrahi̇m Hali̇l

doi:10.1177/1076029613493658

Cited by 27 publications

(18 citation statements)

References 25 publications

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“…The inflammatory state and oxidative stress change the morphology, deforming force, and half-life of red blood cells, increase RDW in vivo, and cause changes in hemodynamic state [27]. RDW clinically influences the severity and prognosis of stroke, acute coronary syndrome, and other diseases [28,29]. Our study displays that preoperative RDW is associated with cognitive decline in CHD patients undergoing CABG.…”

Section: Discussionmentioning

confidence: 66%

Preoperative red cell distribution width predicts postoperative cognitive dysfunction after coronary artery bypass grafting

Wan

Luo

et al. 2020

Bioscience Reports

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We assessed the relationship between red blodd cell distribution width (RDW) and postoperative cognitive dysfunction (POCD) after coronary artery bypass grafting (CABG) in patients who usually had obvious hemodynamic changes. We enrolled 362 coronary heart disease patients who received CABG. POCD was assessed through neuropsychological examination at 21 days after operation. Demographics, history of diseases, blood biochemical parameters and perioperative data were collected. The receiver operating characteristic (ROC) curve was used to find the best cut-off value of RDW for diagnosis of POCD. Logistic regression was used to explore the relationship between RDW and POCD. The 21-day incidence of POCD in patients receiving CABG was 27.1% (98/362). The RDW of POCD patients was significantly higher than in the non-POCD patients (17.4 vs. 13.2). The sensitivity and specificity of RDW for predicting POCD were 82.7 and 64.8%, respectively. The POCD patients also tended to be older and had higher fasting plasma glucose, hypersensitive c-reactive protein, tumor necrosis factor-α, white blood cell levels and longer surgery time. No significant differences were found in other parameters. The 21-day neuropsychological test results were better in the POCD patients than the non-POCD patients. After adjustment of potential factors, the preoperative high RDW was still associated with an increased risk of POCD (odds ratio (OR) = 2.52, 95% confidence interval (CI): 1.28–4.31). Our study indicates that preoperative RDW is significantly elevated in POCD patients receiving CABG. The elevated preoperative RDW is associated with an increased risk of POCD and preoperative RDW can be an independent predictor of POCD.

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Section: Discussionmentioning

confidence: 66%

Preoperative red cell distribution width predicts postoperative cognitive dysfunction after coronary artery bypass grafting

Wan

Luo

et al. 2020

Bioscience Reports

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“…A study about the risk of stroke showed that RDW was an important hematologic index for stroke in patients who had cardiac insufficiency. 26 In addition, high RDW is associated with the development of stroke and is strongly associated with cardiovascular causes and all causes of death in patients who are diagnosed with stroke. 4 Another case-control study showed that RDW is a strong indicator of stroke.…”

Section: Discussionmentioning

confidence: 99%

“… 29 In a follow-up study of 153 patients who had chronic cardiac insufficiency, RDW >15.2% had sensitivity 87% and specificity 74%, and the ROC curve for RDW had an area under the curve of 0.923. 26 However, there are few studies available about the association between stroke and RDW, and there have been insufficient data about the cutoff values of RDW in the prediction of stroke. The present study showed an optimal RDW cutoff of 14% ( Table 3 ) and area under the curve of 0.760 ( Figure 1 ).…”

Section: Discussionmentioning

confidence: 99%

Red cell distribution width and neurological scoring systems in acute stroke patients

Kara¹,

Değirmenci²,

Bayır³

et al. 2015

NDT

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ObjectivesThe purpose of the present study was to evaluate the association between the red blood cell distribution width (RDW) and the Glasgow Coma Scale (GCS), Canadian Neurological Scale (CNS), and National Institutes of Health Stroke Scale (NIHSS) scores in patients who had acute ischemic stroke.MethodsThis prospective observational cohort study included 88 patients who have had acute ischemic stroke and a control group of 40 patients who were evaluated in the Emergency Department for disorders other than acute ischemic stroke. All subjects had RDW determined, and stroke patients had scoring with the GCS, CNS, and NIHSS scores. The GCS, CNS, and NIHSS scores of the patients were rated as mild, moderate, or severe and compared with RDW.ResultsStroke patients had significantly higher median RDW than control subjects. The median RDW values were significantly elevated in patients who had more severe rather than milder strokes rated with all three scoring systems (GCS, CNS, and NIHSS). The median RDW values were significantly elevated for patients who had moderate rather than mild strokes rated by GCS and CNS and for patients who had severe rather than mild strokes rated by NIHSS. The area under the receiver operating characteristic curve was 0.760 (95% confidence interval, 0.676–0.844). Separation of stroke patients and control groups was optimal with RDW 14% (sensitivity, 71.6%; specificity, 67.5%; accuracy, 70.3%).ConclusionIn stroke patients who have symptoms <24 hours, the RDW may be useful in predicting the severity and functional outcomes of the stroke.

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“…RDW has traditionally been used for the differential diagnosis of anemia. [ 1 ] In recent years, several studies have demonstrated that increased RDW is associated with a poor prognosis in clinical settings of cardiovascular and thrombotic diseases, [ 2 ] stroke, [ 3 ] coronary artery disease, [ 4 ] diabetes mellitus, [ 5 ] hypertension, [ 6 ] metabolic syndrome (MS), [ 7 , 8 ] renal function damage, [ 5 , 9 ] and it can be a predictor of all-cause mortality in general population. [ 2 ] However, it has not been well ascertained whether anisocytosis might be a cause or a simple epiphenomenon of the underlining conditions of the above-mentioned diseases, such as inflammation, oxidative stress, under nutrition, and so forth or maybe an element of both.…”

Section: Introductionmentioning

confidence: 99%

No associations exists between red blood cell distribution width and serum uric acid in both sexes

Zhang¹,

Meng²,

Li³

et al. 2018

Medicine

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The aim of this study was to determine whether there was a significant association between red blood cell distribution width (RDW) and uric acid (UA) in a large Chinese population.This was a cross-sectional study with an enrollment of 80,298 ostensibly healthy participants (48,971 males, 31,327 females) during the period from 2011 to 2015. In the study, database was grouped by sex and the association between RDW and UA was analyzed by quartiles of RDW.UA values between different sexes and RDW subgroups were analyzed by 2-way analysis of variance and Bonferroni t tests. Prevalence of hyperuricemia in different sexes was calculated. The relationship between risks of hyperuricemia and RDW level was analyzed by binary logistic regression with or without adjustment for age and body mass index.UA values were not all the same between different sexes and RDW subgroups. Males had significantly higher hyperuricemia prevalence than females (20.00% vs 6.48%, P < .01). In addition, hyperuricemia prevalence in males decreased slightly across RDW quartiles, but was stable in females. No significant association between hyperuricemia risk and RDW was found in both sexes according to the results of multivariate logistic regression analysis. Similarly, negative results were also observed in multivariate linear analysis when both RDW and UA were considered as continuous variable.We could not find any significant relationship between RDW and UA in both sexes.

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Relationship Between Red Cell Distribution Width and Stroke in Patients With Stable Chronic Heart Failure

Abstract: In conclusion, this study demonstrated that RDW may be important hematological indices for stroke in patients with HF using propensity score analysis.

Cited by 27 publications

References 25 publications

Preoperative red cell distribution width predicts postoperative cognitive dysfunction after coronary artery bypass grafting

Preoperative red cell distribution width predicts postoperative cognitive dysfunction after coronary artery bypass grafting

Red cell distribution width and neurological scoring systems in acute stroke patients

No associations exists between red blood cell distribution width and serum uric acid in both sexes

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