Relationship between Retinal Nerve Fiber Layer and Visual Field Sensitivity as Measured by Optical Coherence Tomography in Chiasmal Compression

Danesh‐Meyer, Helen V.; Carroll, Stuart C; Foroozan, Rod; Savino, Peter J.; Fan, Jiwei; Jiang, Yannan; Hoorn, Stephen Vander

doi:10.1167/iovs.06-0327

Cited by 158 publications

(123 citation statements)

References 43 publications

(39 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our study indicated a significant structure-function correlation when assessed using the linear model evaluated by Pearson's correlation coefficients, especially when VFS loss was expressed in 1/L. These findings are similar to those of previous studies on glaucoma (3,29) and other neuro-ophthalmic conditions (5)(6) , suggesting the existence of a possible linear correlation between visual loss and axonal damage. In our study, although all quadrantic measurements in BA eyes differed significantly from normals, the best structurefunction correlation was found between the superonasal macular thickness and inferotemporal VFS, and not between inferonasal thickness and the superotemporal VFS, the correlation which was smaller than expected.…”

Section: Discussionsupporting

confidence: 89%

“…A spatial correspondence between retinal ganglion cell (RGC) loss and visual field (VF) defect in patients with glaucoma has been reported by several authors (1)(2)(3)(4) . However, only a few studies evaluated structure-function relationship in optic neuropathies other than glaucoma (5)(6)(7) . Most of them have cor- one with less than 33% fixation losses, false-positive and false negative responses.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Relationship between visual field sensitivity loss and quadrantic macular thickness measured with Stratus-Optical coherence tomography in patients with chiasmal syndrome

Moura¹,

Costa-Cunha²,

Malta³

et al. 2010

Arq. Bras. Oftalmol.

View full text Add to dashboard Cite

Purpose: To correlate visual field sensitivity (VFS) loss on standard automated perimetry (SAP) and quadrantic macular thickness on optical coherence tomography (OCT) in patients with permanent temporal hemianopia from chiasmal compression. Methods: Forty eyes from 40 patients with chiasmal compression and 40 healthy eyes were submitted to standard automated perimetry and Stratus-OCT scanning. Raw data of the fast macular thickness scanning protocol were exported and macular thickness measurements were recorded and averaged for each quadrant and half of the central area. The correlation between visual field sensitivity loss and optical coherence tomography measurements was tested with Pearson's correlation coefficients and with linear regression analysis. Results: A significant association was found between each macular thickness parameter and the corresponding central VF mean sensitivity. The strongest association was observed between superonasal macular thickness and the inferotemporal mean defect measured both in decibel (R=0.47; p=0.001) and in 1/Lambert (R=0.59; p<0.0001) units. Conclusion: Stratus-OCT-measured macular thickness was topographically related with visual field sensitivity loss in patients with temporal hemianopia from chiasmal compression. Such measurements could prove clinically useful in the diagnosis and follow-up of patients with chiasmal compression. ClinicalTrial.gov identifier number: NCT0039122.Keywords: Tomography, optical coherence; Perimetry; Optic atrophy; Optic chiasm; Hemianopsia; Visual fields RESUMO Objetivo: Avaliar a correlação entre o defeito de campo visual ao exame de perimetria computadorizada e a espessura macular quadrântica ao exame de tomografia de coerência óptica (OCT) em pacientes com hemianopsia temporal permanente causada por compressão quiasmática. Métodos: Quarenta olhos de 40 pacientes com compressão quiasmática e 40 olhos de 40 indivíduos controles foram submetidos aos exames de perimetria computadorizada e tomografia de coerência óptica. Dados não processados foram exportados e as medidas de espessura macular foram calculadas para cada quadrante e metade da área macular central. A correlação entre o defeito campimétrico e as medidas de espessura macular foi avaliada por coeficiente de correlação de Pearson e por análise de regressão linear. Resultados: Associação significante foi encontrada entre os parâmetros de espessura macular e seus respectivos defeitos campimétricos. A correlação mais forte foi encontrada entre o parâmetro espessura macular nasal superior e o defeito campimétrico médio temporal inferior medido em decibel (R=0,47; p=0,001) e em 1/Lambert (R=0,59; p<0,0001). Conclusão: Medidas de espessura macular avaliada através da tomografia de coerência óptica foi topograficamente relacionada ao defeito campimétrico em pacientes com hemianopsia temporal por compressão quiasmática. Estas medidas podem provar a importância clínica no diagnóstico e seguimento dos pacientes com compressão quiasmática. ClinicalTrial.gov identifier number: NCT00391...

show abstract

Section: Discussionsupporting

confidence: 89%

mentioning

confidence: 99%

Relationship between visual field sensitivity loss and quadrantic macular thickness measured with Stratus-Optical coherence tomography in patients with chiasmal syndrome

Moura¹,

Costa-Cunha²,

Malta³

et al. 2010

Arq. Bras. Oftalmol.

View full text Add to dashboard Cite

show abstract

“…1,2 Studies evaluating the relationship between functional and structural measurements of the neural structures of the eye are of great importance for diagnosis and monitoring the course of the disease. VF loss, which is usually assessed using standard automated perimetry (SAP), is the most commonly used parameter to estimate the severity of visual loss.…”

Section: Introductionmentioning

confidence: 99%

Macular thickness measurements with frequency domain-OCT for quantification of axonal loss in chronic papilledema from pseudotumor cerebri syndrome

Monteiro

Afonso

2014

Eye

View full text Add to dashboard Cite

“…Studies investigating the relationship between these parameters are of great importance not only to provide complementary data on the extent of neural damage in patients at risk of irreversible VF loss, but even more importantly to help estimate the chances of reversing visual loss in conditions such as demyelinating or compressive optic neuropathy. [1][2][3] However, most structurefunction relationship studies have focused on patients with glaucoma, [4][5][6][7] and conclusions have not been directly extrapolatable to other optic pathway conditions. The changes in the structural appearance of the optic nerve head (ONH) and RNFL that accompany the development of VF loss in patients with permanent temporal hemianopia from chiasmal compression represent an important model for assessing the diagnostic performance of different instruments for measuring retinal neural structures.…”

Section: Introductionmentioning

confidence: 99%

Correlation between macular and retinal nerve fibre layer Fourier-domain OCT measurements and visual field loss in chiasmal compression

Monteiro

Costa-Cunha

Cunha

et al. 2010

Eye

View full text Add to dashboard Cite

Purpose The aim of this study was to test the correlation between Fourier-domain (FD) optical coherence tomography (OCT) macular and retinal nerve fibre layer (RNFL) thickness and visual field (VF) loss on standard automated perimetry (SAP) in chiasmal compression. Methods A total of 35 eyes with permanent temporal VF defects and 35 controls underwent SAP and FD-OCT (3D OCT-1000; Topcon Corp.) examinations. Macular thickness measurements were averaged for the central area and for each quadrant and half of that area, whereas RNFL thickness was determined for six sectors around the optic disc. VF loss was estimated in six sectors of the VF and in the central 16 test points in the VF. The correlation between VF loss and OCT measurements was tested with Spearman's correlation coefficients and with linear regression analysis. Results Macular and RNFL thickness parameters correlated strongly with SAP VF loss. Correlations were generally stronger between VF loss and quadrantic or hemianopic macular thickness than with sectoral RNFL thickness. For the macular parameters, we observed the strongest correlation between macular thickness in the inferonasal quadrant and VF loss in the superior temporal central quadrant (q ¼ 0.78; Po0.001) whereas for the RNFL parameters the strongest correlation was observed between the superonasal optic disc sector and the central temporal VF defect (q ¼ 0.60; Po0.001).Conclusion Although FD-OCT RNFL and macular thickness measurements were both correlated with VF loss, the correlation was stronger with quadrantic macular than with RNFL thickness measurements in patients with temporal hemianopia. Such measurements could potentially be used to quantify neuronal loss in patients with chiasmal compression.

show abstract

Relationship between Retinal Nerve Fiber Layer and Visual Field Sensitivity as Measured by Optical Coherence Tomography in Chiasmal Compression

Cited by 158 publications

References 43 publications

Relationship between visual field sensitivity loss and quadrantic macular thickness measured with Stratus-Optical coherence tomography in patients with chiasmal syndrome

Relationship between visual field sensitivity loss and quadrantic macular thickness measured with Stratus-Optical coherence tomography in patients with chiasmal syndrome

Macular thickness measurements with frequency domain-OCT for quantification of axonal loss in chronic papilledema from pseudotumor cerebri syndrome

Correlation between macular and retinal nerve fibre layer Fourier-domain OCT measurements and visual field loss in chiasmal compression

Contact Info

Product

Resources

About