Relationship between serotonin transporter gene polymorphism and constipation in cancer patients

Li, Weiwei; Huang, Luli; Cai, Weimei; Cao, Sue; Yuan, Yongyi; Shen, Lu; Zhao, Yanzheng; Lu, Ping

doi:10.5114/wo.2014.41391

Cited by 5 publications

(6 citation statements)

References 23 publications

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“…Constipation is also recognized as one of the main symptoms reported by cancer patients. Nevertheless, behind the chemotherapy there are also biologically active substances that may cause the constipation [ 16 , 17 ]. Müller-Lissner et al .…”

Section: Discussionmentioning

confidence: 99%

Link between diet and chemotherapy related gastrointestinal side effects

Mardas¹,

Mądry²,

Stelmach-Mardas³

2017

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Aim of the studyTo evaluate an association between food products consumption, dietary intake and the incidence of selected gastrointestinal symptoms (nausea, vomiting, diarrhea and constipation) in cancer patients undergoing chemotherapy.Material and methodsFifty six women receiving chemotherapy for ovarian cancer were eligible for the study. Anthropometrical measurements were assessed. The dietary intake was evaluated by 24-hours food records. The association between the consumption of selected food products and gastrointestinal symptoms incidences was assessed by modified semi-quantitative food frequency questionnaire including 77-different food items that was developed and applied in cancer patients undergoing chemotherapy.ResultsBMI values indicated 9%, 45%, 30% and 16% of patients as underweight, normal weight, overweight and obese respectively. Only 23% and 32% of patients never experienced nausea and constipation when 43% and 45% never experienced vomiting and diarrhea. Nausea was promoted by oils, constipation by chocolate and chocolate products and diarrhea by dairy products, stone fruit and apple. Significant inverse correlations were found between vomiting and the intake of energy, fat, protein, carbohydrates, B groups vitamins, vitamin D, phosphorus and zinc. The difference in energy intake between marginal values of vomiting incidence exceeded 400 kcal.ConclusionsDietary intake as well as specific food products influence on gastrointestinal side effect of chemotherapy in cancer patients. The dietary approach based on either exclusion or limited intake of selected food products and improvement of diet could reduce and prevent chemotherapy induced gastrointestinal symptoms therefore should be taken under consideration in clinical practice.

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Section: Discussionmentioning

confidence: 99%

Link between diet and chemotherapy related gastrointestinal side effects

Mardas¹,

Mądry²,

Stelmach-Mardas³

2017

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“…Studies investigating the association between SERT gene polymorphism and constipation focus on patients with cancer ( 117 ) or irritable bowel syndrome (IBS) ( 118 , 119 ). In Li et al’s ( 117 ) study, patients with polymorphism in S/S genotype SERT have a higher risk for constipation.…”

Section: Resultsmentioning

confidence: 99%

“…Studies investigating the association between SERT gene polymorphism and constipation focus on patients with cancer (117) or irritable bowel syndrome (IBS) (118,119) (118,119), it was observed a significant association between SERT polymorphism with predominant constipation IBS (IBS-C). The polymorphisms in SERT genes could lead to downregulation in the 5-HT receptors over time, decreasing the serotonergic effect, which leads to constipation (119).…”

Section: Outstanding Factors To Be Considered For Probiotic Use On Co...mentioning

confidence: 99%

Probiotics, prebiotics, and synbiotics in chronic constipation: Outstanding aspects to be considered for the current evidence

Araújo

Botelho

2022

Front. Nutr.

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This integrative aimed to evaluate the effects and the potential mechanism of action of prebiotics, probiotics, and synbiotics on constipation-associated gastrointestinal symptoms and to identify issues that still need to be answered. A literature search was performed in the PubMed database. Animal models (n = 23) and clinical trials (n = 39) were included. In animal studies, prebiotic, probiotic, and synbiotic supplementation showed a decreased colonic transit time (CTT) and an increase in the number and water content of feces. In humans, inulin is shown to be the most promising prebiotic, while B. lactis and L. casei Shirota probiotics were shown to increase defecation frequency, the latter strain being more effective in improving stool consistency and constipation symptoms. Overall, synbiotics seem to reduce CTT, increase defecation frequency, and improve stool consistency with a controversial effect on the improvement of constipation symptoms. Moreover, some aspects of probiotic use in constipation-related outcomes remain unanswered, such as the best dose, duration, time of consumption (before, during, or after meals), and matrices, as well as their effect and mechanisms on the regulation of inflammation in patients with constipation, on polymorphisms associated with constipation, and on the management of constipation via 5-HT. Thus, more high-quality randomized control trials (RCTs) evaluating these lacking aspects are necessary to provide safe conclusions about their effectiveness in managing intestinal constipation.

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“…Two studies 28 , 29 reported that SS and LS genotypes were risk factors for constipation- and diarrhea-predominant IBS, respectively. On the contrary Li et al 30 in 2007 documented that LL genotype was higher in constipation predominant IBS, and Li et al 31 in 2015 showed that SS genotype was a risk factor for constipation in cancer patients. These contradictory findings may be explained by difference in race, ethnicity, and difference in food habits as well as different mechanisms involved in different disease processes.…”

Section: Discussionmentioning

confidence: 97%

Impact of serotonin transporter gene polymorphism on gut motility in patients with type 2 Diabetes mellitus

Malik

Saha

Morya

et al. 2021

J Neurogastroenterol Motil

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Background/Aims The pathogenesis of gastrointestinal (GI) symptoms in patients with type 2 diabetes mellitus (T2DM) is yet to be delineated clearly. Serotonin, a monoamine neurotransmitter, resides primarily in the gut and plays a vital role in GI system. However, no study has been documented the role of serotonin and serotonin transporter gene (SLC6A4) polymorphism in the development of GI symptoms in T2DM patients. Methods Three hundred diabetes patients attending diabetes clinic at Postgraduate Institute of Medical Education and Research, Chandigarh, and matched healthy controls were enrolled for this study. Plasma from collected blood sample was used for serotonin measurement by enzyme-linked immunosorbent assay method and buffy coat was used for isolation of DNA by phenol chloroform method. Serotonin transporter gene polymorphism was analyzed by polymerase chain reaction method. Results The frequency of short allele (S) and SS genotype was significantly higher in patients with T2DM than controls and was associated with increased risk of T2DM. The frequency of LS genotype showed an association with protection from the disease. Regarding GI symptoms, 78.2% of patients with constipation showed LL and LS genotypes, and 97.7% of patients with diarrhea had SS genotype. The patients without GI symptoms did not show any association of gut motility with genotype. Furthermore, serotonin was significantly higher in diabetic patients who belonged to SS genotype compared to LS or LL genotype and who presented with diarrhea. Conclusion SS genotypes are prone to develop diarrhea because of faster gut motility resulting from higher serotonin levels as compared to LS and LL genotype in T2DM patients.

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Relationship between serotonin transporter gene polymorphism and constipation in cancer patients

Cited by 5 publications

References 23 publications

Link between diet and chemotherapy related gastrointestinal side effects

Link between diet and chemotherapy related gastrointestinal side effects

Probiotics, prebiotics, and synbiotics in chronic constipation: Outstanding aspects to be considered for the current evidence

Impact of serotonin transporter gene polymorphism on gut motility in patients with type 2 Diabetes mellitus

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