Relationship between Serum 25-Hydroxyvitamin D and IgE: National Health and Nutrition Examination Survey 2-Year Results

Cellular and molecular mechanisms of vitamin D in food allergy

“…This proposal describes a U-shaped relationship between vitamin D status and food allergy predisposition, where too little or too much vitamin D provides the greatest risk. [36][37][38] In a biochemical plausibility context, the U-shaped curve for allergies is supported by the discovery of a nonlinear relationship of vitamin D concentrations with IgE levels, of which are used as a marker of allergic status. 39,40 However, a recent review determined that there was not enough longitudinal or controlled data on allergies and vitamin D to confirm the shape of the relationship, nor was there sufficient evidence to suggest the U-shape of vitamin D in relation to the risk of any disease investigated, including food allergies.…”

“…50 An examination of data from the National Health and Nutrition Examination Survey revealed that serum vitamin D levels are inversely proportional to total IgE levels. 37 In B cells, vitamin D inhibits IgE production and promotes anti-inflammatory IL-10 through local activation and binding to the VDR. 50 After adjustment for factors such as sex, lifestyle, geographical location and month of blood draw, a cross-sectional study found IgE concentrations were 29% higher in participants with vitamin D deficiency (25(OH) D < 25 nmol/L) than the group with sufficient levels of vitamin D. 39 Furthermore, IgE levels were 56% higher in the group of participants with the highest vitamin D concentrations (25(OH)D > 135 nmol/L), indicating a nonlinear relationship and threshold effect of vitamin D and IgE.…”

“…Despite more evidential weight in the risk of food allergies in those with vitamin D insufficiency than oversupply, a U‐shaped curve has been proposed. This proposal describes a U‐shaped relationship between vitamin D status and food allergy predisposition, where too little or too much vitamin D provides the greatest risk . In a biochemical plausibility context, the U‐shaped curve for allergies is supported by the discovery of a nonlinear relationship of vitamin D concentrations with IgE levels, of which are used as a marker of allergic status .…”

“…Markers of sensitization and allergy, namely IgE and cytokines, have been explored in relation to vitamin D. Overproduction of IL‐4 and subsequent IgE production is a major characteristic of allergic status . An examination of data from the National Health and Nutrition Examination Survey revealed that serum vitamin D levels are inversely proportional to total IgE levels . In B cells, vitamin D inhibits IgE production and promotes anti‐inflammatory IL‐10 through local activation and binding to the VDR .…”

Prospective Study of Vitamin D Status and Risk of Developing Specific Immunoglobulin E During Mid‐Childhood

“…Thus, an investigation of the relationship between vitamin D status and IgE levels is warranted. Observational studies in the general population reveal an inconsistent association between serum 25-hydroxyvitamin D (25(OH)D) and total IgE, with some studies showing positive, negative, or nonlinear relationships [3,4]. Studies have shown mixed results among the paediatric population [5,6].…”