Relationship between Serum C-reactive Protein Levels and Severity of Plasmodium falciparum Malaria in Children Seen in South-South Nigeria

Edet, U; Emmanuel, Ikpeme Enobong; Jackson, Udo Jacob; Samuel, Okpokowuruk Frances

doi:10.9734/ijtdh/2014/10912

Cited by 2 publications

(1 citation statement)

References 22 publications

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“…A significant one is C-reactive protein. Previous studies on usefulness of C-reactive protein in malaria have only centered on the conventional CRP [11, 12, 30–34] while those involving hs-CRP have focused on cardiovascular diseases [18–21], sepsis [22], HIV [23], and cognitive impairment [24]. However, till date, no study has been conducted to assess the expediency of hs-CRP in malaria and its attendant morbidity.…”

Section: Discussionmentioning

confidence: 99%

High-Sensitivity C-Reactive Protein: A Potential Ancillary Biomarker for Malaria Diagnosis and Morbidity

et al. 2019

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Background. Malaria remains an important cause of morbidity and mortality in Africa. Previous studies that assessed C-reactive protein (CRP) have centered on the conventional method. This study evaluated the usefulness of high-sensitivity CRP (hs-CRP) in malaria diagnosis and morbidity in a pediatric population in Ghana. Methodology. A total of 267 subjects (100 microscopically proven nonmalarial parasitaemics as controls and 167 plasmodium parasitaemic subjects as cases), between the ages of 7 months and 18 years, were recruited for this case-control study. Blood samples were collected for malaria parasite density by microscopic examination; full blood count, electrolytes, and liver function tests using an automated analyzer; and hs-CRP levels by sandwich ELISA method. Results. The median hs-CRP concentration was lowest in the control group and increased significantly from low to high parasitaemia. The median hs-CRP level was significantly higher in high malaria parasitaemia compared to moderate and low malaria parasitaemia. Increasing hs-CRP cutoff (3.12-4.64 mg/L) presented with increasing specificity (79.3-93.1%) and sensitivity (96.4%-97.4%), except for moderate parasitaemia where a decline in sensitivity (80.9%) was observed. However, hs-CRP had relatively lower PPV but high NPV at low parasitaemia while both the PPV and NPV were moderate in moderate parasitaemia. Conclusion. hs-CRP yielded a high sensitivity, specificity, and accuracy for low, moderate, and high-grade malaria, respectively, and thus may serve as an effective supplementary diagnostic and prognostic biomarker for Plasmodium parasite infection. However, hs-CRP might not be readily useful yet for diagnostic purposes in hospitals due to the relatively low PPV and NPV for low and moderate parasitaemia and thus necessitates further studies in larger cohorts.

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Section: Discussionmentioning

confidence: 99%

High-Sensitivity C-Reactive Protein: A Potential Ancillary Biomarker for Malaria Diagnosis and Morbidity

et al. 2019

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Study about relationship between C-reactive protein (CRP) and other indicators in children with malaria

Hien¹,

Yeboah²,

Adou³

et al. 2016

J. Infect. Dis. Immun.

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Measurement of C reactive protein rate in children suffering from falciparum malaria was done in order to determine its relationships according to parasite density, white blood cells, age and hemoglobin. This study was a prospective cross-sectional with descriptive and analytical purpose. It focused on 50 children aged from 0 to 15 years admitted in the Pediatric departments of university hospitals in Cocody and Treichville for malaria (Abidjan). Venous blood samples were collected on ethylenediaminetetraacetic acid (EDTA) for blood cells count, parasite density and identification of Plasmodium falciparum. The samples, collected without EDTA were used to measure C Reactive Protein. With the blood collected, the serum was processed on the same day and preserved at-20°C. Giemsa-stained thin and thick blood films were analyzed by microscope for plasmodium species and parasite densities. Hematological parameters were determined using hematology cell counter. Turbidimetric test was used for quantitative detection of C Reactive Protein. Statistical analysis was carried out using SPSS (Statistical Package for Social Science) Version 18.0 and Excel 2007. For all test p-value <0.05 below was considered significant. High levels of C reactive protein were observed in all of patients. Younger children had higher C-reactive protein (CRP) level. Positive strong correlation was noted between CRP and both parasite density and leukocytes. There was negative correlation between C reactive protein rate and age. In children suffering from severe anemia, the negative correlation observed between CRP and hemoglobin level was stronger than those suffering from moderate anemia. The main finding of this study was the involvement of CRP in malaria anemia. The levels of CRP according to age in children with falciparum malaria could be used as a biomarker for assessing anemia.

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Relationship between Serum C-reactive Protein Levels and Severity of Plasmodium falciparum Malaria in Children Seen in South-South Nigeria

Cited by 2 publications

References 22 publications

High-Sensitivity C-Reactive Protein: A Potential Ancillary Biomarker for Malaria Diagnosis and Morbidity

High-Sensitivity C-Reactive Protein: A Potential Ancillary Biomarker for Malaria Diagnosis and Morbidity

Study about relationship between C-reactive protein (CRP) and other indicators in children with malaria

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