Relationship Between Serum Leptin Levels and Weight Gain in Girls with Central Precocious Puberty at 1-Year Follow-Up

Zurita‐Cruz, Jessie Nallely; Villasís-Keever, Miguel Ángel; Damasio-Santana, Leticia; Manuel‐Apolinar, Leticia; Nishimura‐Meguro, Elisa; Rivera-Hernández, Aleida; Garrido‐Magaña, Eulalia; Gutierrez-Gonzalez, Alejandro; Poblano-Alcalá, Adriana

doi:10.4158/ep161620.or

Cited by 3 publications

(1 citation statement)

References 31 publications

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“…Increased leptin levels in obese patients lead to an increase in growth rate by acting on the epiphyseal growth plates, resulting in advanced bone age. 9,10 It was reported that bone age, rather than chronological age, determines the onset of puberty. 11 We planned this study to determine the prevalence of obesity and overweight, to evaluate the association between obesity and bone age, and to investigate the relationship between obesity and hormone pro le in patients followed up for precocious puberty.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the association between precocious puberty and obesity

Polat

2022

Sakarya Medical Journal

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Objective: The marked variation in the timing of puberty despite similar living conditions shows that many factors are effective in determining the onset of puberty. Many factors, such as genetic and environmental factors, stress, socioeconomic status, metabolic rate, and body fat ratio, affect the age of puberty onset. Recent studies have shown that the age of puberty onset has shifted to earlier ages. The increasing prevalence of childhood obesity is deemed to contribute this change. Therefore, we planned the present study to determine the rates of obesity and overweight, to evaluate the association between obesity, bone age, and height age, and to examine the association between obesity and hormone profile. Materials and Methods: The medical records of 206 patients diagnosed with idiopathic precocious puberty who were being followed up at the Pediatric Endocrinology outpatient clinic of Sakarya Training and Research Hospital between October 2018 and October 2021 were retrospectively reviewed. Anthropometric data (age, gender, height, weight, body mass index, and puberty stage), bone age, height age, and weight age of the patients were recorded from the medical records. Patients were grouped as normal weight, overweight, and obese by body mass index (BMI). Results: Of the included patients, 97.6% (201 patients) were female and 2.4% (5 patients) were male. One hundred and thirty-one patients (63.6%) had normal weight, 40 (19.4%) were overweight and 35 (17%) had obesity. Significant differences were found between the groups (normal weight, overweight and obese) in terms of weight age, BMI percentile, height age, bone age, and bone age standard deviation score (SDS) (p =

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Section: Introductionmentioning

confidence: 99%