Relationship Between Serum Total Testosterone and Coronary Artery Disease in Men

Abstract

Background: Male sex has always been considered as an independent risk factor for cardiovascular disease. But recent studies have shown controversial results. This study aimed to investigate the relation of serum testosterone withrisk factors of coronary artery diseasesand with degree of severity of coronary artery stenosisin men with coronary artery diseases.Methods: After applying inclusion and exclusion criteria 102 men (aged 60.42 += 11.11), were included. Fasting blood sample were obtained and blood sugar, total testosterone and lipid profile were measured. Severity of coronary stenosis was estimated by Gensini score. The relationships were assessed using chi-square test, one way analysis of variance and Pearson’s Correlation. Results: Of the total 102 patients, majority of them 42 (41.2%) had triple vessel disease. Testosterone (nmol/L) was found to be 12.01 ± 6.1. Cardiovascular diseaserisk factors like age, body mass index etc. were found to be negatively correlated with testosterone but not statistically significant. Likewise, Gensini score also correlated negatively with testosteronebut not up to the threshold of statistical significance (r=-0.069, p-value = 0.496). Similar results were obtained when number of vessels involved and testosterone were compared. However, the number of diabetic patients gradually decreased with the increasing value of testosterone in the three tertile group (p-value = 0.040). Conclusions: This study could not find significant association between testosterone and coronary artery diseases, however low testosterone was associated with diabetes mellitus.Keywords: Coronary artery diseases; diabetes mellitus; gensini score; testosterone.

Relationship Between Testosterone Deficiency and the Cardiovascular Risk Ractors, Diabetes and Hypertension

“…TD has been reported to increase the risk for cardiovascular disease. 18 However, some studies have reported the occurrence of TD in people with obesity, high blood pressure, or diabetes. 10,11 Another study revealed the inverse relationship between metabolic syndrome and testosterone and associated triglycerides and elevated blood pressure with low testosterone.…”

“…19 Hence, the causal relationship between testosterone and obesity, hypertension, or diabetes is not clear due to the complex relationship among age, obesity, and other cardiovascular risk factors. 18,20 Therefore, we examined these relationships by conducting a longitudinal study. Our results reveal that the RR of disease is higher in men with TD than in those without TD.…”