Relationship between serum total testosterone and prostate volume in aging men

Xia, Bo-Wen; Zhao, Songlin; Chen, Zongping; Chen, Chao; Liu, Tianshu; Yang, Fan; Yan, Yong

doi:10.1038/s41598-021-93728-1

Cited by 18 publications

(20 citation statements)

References 40 publications

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“…Elevated prostate weight (PW) and prostate index (PI) often points to an impending BPH because of its contribution to the symptoms preceding BPH, which includes lower urinary tract symptoms [19]. This study also recorded an increase in prostate weight in BPH control relative to the normal control suggesting BPH progression and proliferation of prostate tissues and cells.…”

Section: Discussionmentioning

confidence: 54%

Combined ethanol extract of Hypselodelphys poggeana and Spermacoce radiata leaves ameliorate benign prostatic hyperplasia in rats via modulation of serum sex hormonal levels

Uroko¹,

Ijioma²,

OGWO³

et al. 2022

jrp

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This study evaluated the effects of a combined ethanol extract of and Hypselodelphys poggeana and Spermacoce radiata leaves (CESHL) on sex hormone levels and prostate weights of benign prostatic hyperplasia (BPH) induced rats. The combined extract was prepared from the plants and was subjected to acute toxicity (LD50) evaluation in rats. The study adopted five groups of rats (n = 6) with group 1 being the normal control without BPH induction, group 2 was the BPH control, group 3 was the finasteride control, and groups 4 and 5 were BPH induced rats treated with 250 and 500 mg/kg CESHL/day for 28 days. Induction of prostate hyperplasia in rats belonging to groups 2-5 was done via daily subcutaneous administration of testosterone propionate (5 mg/kg body weight) for 28 days in accordance with standard protocols. The result obtained in the acute toxicity evaluation indicated an LD50 value of above 5000 mg/kg body weight. In the main study, a significant increase (P<0.05) in serum testosterone, dihydrotestosterone, prostate weight, prostate index and reduced serum estradiol was observed in the BPH control when compared with the normal control. Treatment of BPH induced rats (groups 4 and 5) with CESHL significantly reduced serum concentrations of testosterone and dihydrotestosterone, and also elevated serum estradiol concentration when compared with the BPH control, comparing favourably with the values of these hormones in the finasteride-treated group. The BPH induced rats treated with CESHL also had significantly reduced prostate weight and prostate index relative to the BPH control and higher percentage inhibition of prostate weight and prostate index when compared with the finasteride control. Our findings show that CESHL may ameliorate benign prostate hyperplasia via mechanisms that lower serum testosterone and dihydrotestosterone levels and increase estradiol levels.

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Section: Discussionmentioning

confidence: 54%

Combined ethanol extract of Hypselodelphys poggeana and Spermacoce radiata leaves ameliorate benign prostatic hyperplasia in rats via modulation of serum sex hormonal levels

Uroko¹,

Ijioma²,

OGWO³

et al. 2022

jrp

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“…The number of attempts in group PM (1[1-1]) was significantly fewer than groups M (2[1-2]) or P (2[1-2]), P < 0.05. The time taken to perform spinal anesthesia in group PM was significantly shorter than group M (P < 0.05), but was not different from group P. The number of needle redirections in group PM (1[0-2]) was significantly fewer than group M (2[1-3.25], P < 0.05), but there was no statistically significant difference with group P (1 [1][2]). The patient satisfaction score during the process of puncturing was higher in group PM (4 [4][5]) than groups M (4 [3][4], P < 0.05) or P (4[3.5 -4], P < 0.05).…”

Section: Resultsmentioning

confidence: 83%

“…Studies have shown that the risk of many urinary system diseases (such as benign prostatic hyperplasia, bladder tumors, or urethral stricture) increase drastically with ageing. Even for patients who have undergone urethroplasty, the decline of detrusor function related to age may cause repeat urinary difficulties [2][3][4]. Compared with general anesthesia, spinal anesthesia has been recognized as providing greater hemodynamic stability, higher patient satisfaction, lower rate of opioid use, higher rate of opioid-free recovery, and lower maximum Post-Anesthesia Care Unit (PACU) pain scores [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Ultrasound-assisted modified paramedian technique for spinal anesthesia in elderly

et al. 2022

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Background At present, there are two techniques which are widely applied clinically; the midline and the paramedian. Both methods are difficult for clinicians when treating the elderly. The aim of this work is to explore the feasibility of an ultrasound-assisted modified paramedian technique for spinal anesthesia in the elderly. This would provide clinicians with a new and easy-to-operate technique. Methods A total of 150 elderly patients who were scheduled for urology surgery under spinal anesthesia in our hospital were randomly divided into three groups (n = 50): (i) midline technique group (group M), (ii) paramedian technique group (group P), and (iii) modified paramedian technique group (group PM). All spinal anesthesia were performed by the same second-year resident. Results Compared with groups M and P, group PM had significantly higher first-attempt success rate (P < 0.05, especially in patients aged 65-74 years), fewer attempts (P < 0.05), and higher patient satisfaction score (P < 0.05). Compared with group M, the time taken to perform spinal anesthesia and the number of needle redirections were significantly reduced in group PM (P < 0.05). There was no statistically significant difference between groups PM and P. There were also no statistically significant differences in the cases of inconsistency between ultrasound-assisted and landmark-guided location of intervertebral space, the time taken to ultrasound-assisted location, the onset time to pain block at T10, the incidence of hypotension, anesthesia effect and the incidence of headache, lower back pain, or nausea and vomiting, within 24 h after surgery. Conclusions The modified paramedian technique in spinal anesthesia for elderly patients can significantly improve the first-attempt success rate, reduce both the number of attempts and procedure time, and minimize tissue damage during the operation. Compared with the traditional techniques, the modified paramedian technique combines the advantages of both the midline and the paramedian methods, and is easy to learn. It is worthy of further research and application. Trial registration Prospectively registered at the China Clinical Trial Registry, registration number ChiCTR2100047635, date of registration: 21/06/2021.

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“…Testosterone levels decline with age, resulting in the deterioration of men’s health [ 13 , 14 ]. Accumulating evidence supports the benefits of testosterone replacement therapy for treating symptoms of late-onset hypogonadism and improving lower urinary tract symptoms (LUTS) [ 15 ] and numerous metabolic conditions, such as insulin resistance, adiposity, and dyslipidemia [ 16 ]. The total serum testosterone level was found to be negatively correlated with prostate volume, suggesting a relationship with benign prostate hyperplasia (BPH), insulin level, and an array of obesity-related factors that further linked testosterone to metabolic syndrome [ 16 , 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Predictive Values of Nocturia and Its Voiding Frequency on the Aging Males’ Symptoms

Yuen

Wong

Chiu

et al. 2022

IJERPH

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Background: The link between nocturia and aging male symptoms (AMS) has not been scientifically established. This study aimed to measure the degree of severity of AMS that impacts health-related quality of life (HRQoL) in adult males living with nocturia and to determine the predictive values of nocturnal factors on AMS. Methods: This is an extended analysis of new data collected by using the Hong Kong Traditional AMS (HK-AMS) scale and the Cantonese version of the Pittsburgh Sleep Quality Index (PSQI) in a recently published cross-sectional population-based survey. Results: Of the 781 respondents that completed the set of questionnaires, 68% and 61% of men living with nocturia reported clinically significant (at moderate-to-severe levels) somato-vegetative and sexual AMS; the prevalence and severity were increased with advancing nighttime voiding frequency. Age, the Global PSQI score, certain metabolic diseases, the nocturia-specific QoL (NQoL) score and bedtime voiding frequency were found to be significant predictive factors for composite somato-vegetative and sexual AMS. Conclusions: The current findings suggested the inclusion of nocturia when measuring male-specific HRQoL related to aging.

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Relationship between serum total testosterone and prostate volume in aging men

Cited by 18 publications

References 40 publications

Combined ethanol extract of Hypselodelphys poggeana and Spermacoce radiata leaves ameliorate benign prostatic hyperplasia in rats via modulation of serum sex hormonal levels

Combined ethanol extract of Hypselodelphys poggeana and Spermacoce radiata leaves ameliorate benign prostatic hyperplasia in rats via modulation of serum sex hormonal levels

Ultrasound-assisted modified paramedian technique for spinal anesthesia in elderly

Predictive Values of Nocturia and Its Voiding Frequency on the Aging Males’ Symptoms

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