Relationship between serum uric acid and clustering of cardiovascular disease risk factors and renal disorders among Shanghai population: a multicentre and cross-sectional study

Tao, Min; Pi, Xiaoling; Ma, Xiaoyan; Shi, Yingfeng; Zhang, Yuzhen; Gu, Hang; Chi, Yongbin; Zhuang, Songlin; Liu, Na

doi:10.1136/bmjopen-2018-025453

Cited by 26 publications

(31 citation statements)

References 53 publications

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“…In addition to these studies, Yu et al [21] have reported that SUA can induce oxidative stress and activation of local RAS system leading to senescence and apoptosis, showing a mechanism of uric acidinduced human umbilical vein endothelial dysfunction. Clinical studies have also indicated the relationship between SUA and endothelial dysfunction [22][23][24][25]. As our data showed a weak inverse correlation between SUA and endothelial function, the raised SUA, even in physiological range, may reflect he endothelial dysfunction.…”

Section: Open Access Freely Available Onlinesupporting

confidence: 59%

“…We also add the estimation whether eGFR 60 mL/ min/1.73 m 2 of renal function is related with SUA. Furthermore, experimental and clinical studies have also indicated the relationship between SUA and endothelial dysfunction [21][22][23][24][25]. Therefore, we have studied whether interrelationship among eGFR>60 mL/ min/1.73 m 2 , FMD and SUA are correlated.…”

Section: Introductionmentioning

confidence: 99%

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Association of Brachial Artery Measures with Estimated GFR>60 mL/min/1.73 m2 in a Cross-Sectional Study of the Community-Based Women

Fujioka¹,

Oishi²,

Nakayama³

et al. 2019

Angiol Open Access

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Objective: The purpose of this study is to estimate whether early decline in kidney disease is correlated with brachial artery measures as surrogate markers of the endothelial function in community-based women. Methods:We studied 36 women with estimated glomerular filtration rate (eGFR)>60 mL/min/1.73 m 2 in community-based population women were enrolled in this study. Brachial artery measures including Flow-Mediated Vasodilation (FMD), Nitroglycerin-Mediated Vasodilation (NMD), Brachial Artery Diameter (BAD), FMD/NMD ratio and Post-Nitroglycerin Brachial Artery Diameter (P-NTGD) examinations were measured in all subjects by using brachial artery ultrasonography. The eGFR was calculated using the Japanese GFR inference formula, which was developed by the Japanese Society of Nephrology. Results:There was significantly positive correlation between eGFR and FMD (r=0.348, p=0.041), positive correlation between eGFR and FMD/NMD ratio (r=0.471, p=0.004) and negative correlation between eGFR and P-NTGD (r=-0.405, p=0.016) were recognized. Negative correlation between Serum Uric Acid (SUA) and eGFR (r=-0.335, p=0.049) and negative correlation between FMD and SUA (r=-0.34, p=0.045) were also demonstrated. Conclusion:Mild renal dysfunction with eGFR>60 mL/min/1.73 m 2 was associated with endothelial dysfunction in women. The cardio-renal interrelationship may be also suggested under mild renal dysfunction. It can be suggested that mild renal dysfunction might be a cardiovascular risk factor in women. Though it should not be distinctly stated just based on the results of the study.Citation: Fujioka K, Oishi M, Nakayama T, Fujioka A (2019) Association of brachial artery measures with estimated GFR>60 mL/min/1.73 m 2 in a crosssectional study of the community-based women. Angiol Open Access. 7:231.

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Section: Open Access Freely Available Onlinesupporting

confidence: 59%

Section: Introductionmentioning

confidence: 99%

Association of Brachial Artery Measures with Estimated GFR>60 mL/min/1.73 m2 in a Cross-Sectional Study of the Community-Based Women

Fujioka¹,

Oishi²,

Nakayama³

et al. 2019

Angiol Open Access

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“…5,6 Originally, obesity was considered a predisposing risk factor, although nowadays, according to the American Heart Association, it has been upgraded to the principal factor. [7][8][9] The key risk factors are additive, due to their predictive power. Consequently, total risk of CVD is the sum of respective risks arising from the incidence of major CRFs.…”

Section: Introductionmentioning

confidence: 99%

<p>Age-Dependent Disparities in the Prevalence of Single and Clustering Cardiovascular Risk Factors: A Cross-Sectional Cohort Study in Middle-Aged and Older Adults</p>

Macek¹,

Žák²,

Terek-Derszniak³

et al. 2020

CIA

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Background: Cardiovascular diseases (CVDs) are the leading cause of mortality worldwide; with age acknowledged as an independent cardiovascular risk factor (CRF) in adults. Appreciating the association between age and classic CRFs is believed to boost all potential benefits of prevention. Purpose: Assessment of the prevalence of single and clustered CRFs and their association with age. Patients and Methods: The survey involved 4735 people (33.6% men) who were PONS project attendees aged 45-64. The study protocol comprised the Health Status Questionnaire, general medical examination, anthropometric measurements, and blood and urine sampling. The prevalence of single and clustered CRFs (hypertension, dyslipidemia, diabetes mellitus, and obesity) in the incrementally split age groups was calculated. The incidence rate of CRFs, against their absence, was determined by Poisson regression models with robust standard errors. Results: The prevalence of CRFs was established in 90% of the respondents. Except dyslipidemia and ≥1 CRFs, prevalence of risk factors increased with age, although this trend was the weakest in men. In the total group, and in women, prevalence of dyslipidemia and ≥1 CRFs was unrelated to age, whereas in men, it was on the rise in the younger age groups. The incidence rate of CRFs was strongly related to age, and, with the exception of dyslipidemia, was higher in the older age groups. Conclusion: Cardiovascular risk factors are common in the adult population, while their prevalence and clustering are more prevalent in seniors. Apart from dyslipidemia, the risk of CRFs is appreciably age-related, and higher in seniors.

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“…Studija Tao i sar. ukazuje da je hiperurikemija specifično udružena sa KV faktorima rizika kod žena (18). Stubnova i sar.…”

Section: Diskusijaunclassified

The relationship between uric acid concentration and cardiovascular risk: Retrospective analysis of patients on hemodialysis

Radović¹,

Milinković²,

Stošović³

et al. 2019

Arhiv za farmaciju

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Literaturni podaci ukazuju da povećana koncentracija mokraćne kiseline (MK) predstavlja značajan faktor rizika za kardiovaskularne bolesti. Cilj ove studije bio je da se retrospektivnom analizom ispita povezanost MK sa faktorima rizika za kardiovaskularne bolesti kod bolesnika na hemodijalizi. Za 110 bolesnika analizirane su vrednosti osnovnih parametara funkcije bubrega, metabolizma kostiju i faktora rizika za kardiovaskularne bolesti u periodu od 2010. do 2017. godine. Rezultati ukazuju na značajno povećanje koncentracije uree (P=0,004), kreatinina (P=0,028) i neorganskog fosfata (P˂0,001), kao i značajne razlike u zavisnosti od pola (P=0,013) u kategorijama rizika definisanim na osnovu granične koncentracije MK (cut off <350 µmol/L). Nakon kontrolisanja efekta većine parametara, statistički značajne vrednosti koeficijenata korelacije dobijene su za MK i ureu (r=0,361; P=0,0013), kreatinin (r=0,388; P=0,0005) i neorganski fosfat (r=0,366; P=0,0011). Značajni regresioni koeficijenti su dobijeni za MK i muški pol (β=-0,227, P=0,004), godine starosti (β=-0,298, P˂0,001), ureu (β=0,271, P=0,005) i neorganski fosfat (β=0,232, P=0,009). Prediktivna vrednost nezavisnih parametara u odnosu na MK je potvrđena za muški pol (OR=3,595; 95% CI: 1,421-9,094; P=0,007) i neorganski fosfat (OR=14,842; 95% CI: 2,518-87,472, P=0,003). Cox-ovom regresijom proporcionalnih nepoželjnih ishoda dobijen je najznačajniji udruženi efekat indeksa telesne mase i adekvatnosti dijalize na koncentraciju MK u odnosu na dužinu trajanja hemodijalize (P<0,0001). Rezultati ove dugoročne studije ukazuju da se MK ne može smatrati nezavisnim faktorom rizika za kardiovaskularne bolesti, ali da je kod bolesnika na HD, potrebno strateški kontrolisati nivo MK u cilju smanjenja posledičnih komplikacija, morbiditeta i mortaliteta.

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Relationship between serum uric acid and clustering of cardiovascular disease risk factors and renal disorders among Shanghai population: a multicentre and cross-sectional study

Cited by 26 publications

References 53 publications

Association of Brachial Artery Measures with Estimated GFR>60 mL/min/1.73 m2 in a Cross-Sectional Study of the Community-Based Women

Association of Brachial Artery Measures with Estimated GFR>60 mL/min/1.73 m2 in a Cross-Sectional Study of the Community-Based Women

<p>Age-Dependent Disparities in the Prevalence of Single and Clustering Cardiovascular Risk Factors: A Cross-Sectional Cohort Study in Middle-Aged and Older Adults</p>

The relationship between uric acid concentration and cardiovascular risk: Retrospective analysis of patients on hemodialysis

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