Relationship between serum uric acid and hypertension: a cross-sectional study in Bangladeshi adults

Ali, Nurshad; Mahmood, Sharmeen; Islam, Farjana; Rahman, Shahnaz; Haque, Tangigul; Islam, Shiful; Rahman, Shahedur; Haque, Nazmul; Mosaib, Golam; Perveen, Rasheda; Khanum, Farida Adib

doi:10.1038/s41598-019-45680-4

Cited by 75 publications

(73 citation statements)

References 46 publications

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“…Trained medical personnel and graduate‐level students performed the anthropometric measurements according to the standard procedure described elsewhere . Individual's body weight and height were measured to calculate the body mass index (BMI), which was calculated as weight in kilogram divided by height in metres squared.…”

Section: Methodsmentioning

confidence: 99%

Prevalence of elevated liver enzymes and its association with type 2 diabetes: A cross‐sectional study in Bangladeshi adults

Islam

Rahman

Haque

et al. 2020

Endocrino Diabet & Metabol

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Background: Type 2 diabetes (T2D) is a major public health concern affecting millions of people worldwide. The relationship between liver enzymes and T2D has been reported in limited studies; however, there is still a lack of evidence for the Bangladeshi population. This study aimed to evaluate the prevalence of elevated liver enzymes and examine its association with the prevalence of T2D in Bangladeshi adults.Methods: A total of 270 individuals (110 diabetic and 160 nondiabetic) were enrolled in the study. Alanine and aspartate aminotransferase (ALT, AST), alkaline phosphatase (ALP) and γ-glutamyltransferase (GGT) activities were measured in blood serum collected from them. T2D was defined as fasting blood glucose (FBG) ≥126 mg/dL or self-reported recent use of insulin or antidiabetic medications. Association between liver enzymes and T2D was evaluated by multinomial logistic regression analysis. Results:Overall, 61.2% of participants in T2D and 37.1% of participants in the nondiabetes group had at least one or more elevated liver enzymes. The mean concentrations of serum ALT, AST, ALP and GGT were significantly higher in the T2D group compared to the nondiabetes group. The prevalence of elevated liver enzymes was significantly higher in the diabetes group compared to the nondiabetes group (P < .01). In regression analysis, serum GGT activity showed an independent association with the prevalence of T2D. Conclusions:A high prevalence of elevated liver enzymes was observed in subjects having diabetes. Increased serum GGT activity was independently associated with the prevalence of T2D among Bangladeshi adults. More studies of this nature should be carried out in developing countries to get proper insights into the involvement of liver enzymes in T2D. K E Y W O R D SBangladeshi adults, liver enzymes, prevalence, type 2 diabetes

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Section: Methodsmentioning

confidence: 99%

Prevalence of elevated liver enzymes and its association with type 2 diabetes: A cross‐sectional study in Bangladeshi adults

Islam

Rahman

Haque

et al. 2020

Endocrino Diabet & Metabol

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“…A standard questionnaire was used to collect demographic and lifestyle information from the participants. Individual anthropometric data such as age, gender, weight and height were recorded in the questionnaire form followed a standard procedure described elsewhere [21][22][23][24][25][26] . Briefly, systolic and diastolic blood pressure (SBP and DBP) were measured twice in the left arm of the participants with an automated sphygmomanometer (Omron M10, Omron Corporation, Tokyo, Japan) in the seated position after at least 10 minutes of rest.…”

Section: General Data Collectionmentioning

confidence: 99%

“…The blood samples were centrifuged and stored the isolated serum at −20 °C until laboratory analysis. Serum uric acid (SUA), fasting blood glucose (FBG), total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were measured by colorimetric methods with a semi-auto biochemistry analyzer (Humalyzer 3000, USA) described elsewhere 21,22,26 . The diagnostic kits were purchased from Human Diagnostic (Germany) for analysis of the above clinical parameters.…”

Section: General Data Collectionmentioning

confidence: 99%

Association between serum uric acid and metabolic syndrome: a cross-sectional study in Bangladeshi adults

Ali

Miah

Hasan

et al. 2020

Sci Rep

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108

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& farjana islam elevated levels of serum uric acid (SUA) have been suggested to associate with cardiovascular disease, diabetes and metabolic syndrome (MetS). However, information is limited on the association between SUA and MetS in general adults. this study aimed to assess the relationship of SUA with MetS and its components in general adults in Bangladesh. A total of 420 participants were enrolled in this study and biochemical parameters including SUA, fasting blood glucose (FBG) and lipid profile were analyzed using standard methods. The NECP criteria were applied to define MetS. The association of SUA with MetS and its components were evaluated by multinomial logistic regression models. the overall prevalence of MetS was 22% with 21.9% in males and 22.1% in female participants. Male subjects had a high prevalence of elevated components of MetS than in the female subjects (p < 0.05 for all cases). The mean concentration of SUA was significantly higher in subjects of the MetS group compared to the non-MetS group (p < 0.05). The components of MetS were raised with the increasing concentrations of SUA across the quartiles. In regression analysis, SUA was significantly associated with the prevalence of MetS in Bangladeshi adults. In conclusion, elevated SUA was significantly associated with the prevalence of MetS and its components.

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“…Waist circumference (WC) was measured using a general tape that was placed midway between the lowest border of the ribs and iliac crest. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) were measured by an automated sphygmomanometer (Omron M10, Omron Corporation, Tokyo, Japan) and the average value was used in the calculation [24][25][26]. The accuracy of the obtained data was confirmed by repeated-measures analysis.…”

Section: General Data Collectionmentioning

confidence: 99%

Association of microalbuminuria with metabolic syndrome: a cross-sectional study in Bangladesh

Saadi¹,

Roy

Haque

et al. 2020

BMC Endocr Disord

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Background and aims The objectives of this study were to estimate the prevalence of microalbuminuria and examine the association of microalbuminuria with metabolic syndrome (MetS) and its component in a Bangladeshi adult cohort. Methods This cross-sectional study included 175 subjects (84 males and 91 females; aged 19–59 years), recruited from the outdoor Department of Medicine and Endocrinology of a medical college hospital in Dhaka, Bangladesh. Lipid profile and fasting blood glucose (FBG) were measured in serum and albumin and creatinine were determined in urine samples. Microalbuminuria was defined as the urinary albumin-to-creatinine ratio (ACR) of 30 to 300 mg/g. The MetS was defined according to the criteria of the National Cholesterol Education Program (NECP). The association of microalbuminuria with MetS and its components was evaluated by multivariate logistic regression analysis. Results Among the study subjects, 66.3% were hypertensive and 70.3% were diabetic individuals. Overall, the prevalence of microalbuminuria was 29.7% with 31% in males and 28.6% in females. Microalbuminuria was 2.6 fold higher in hypertensive and diabetic adults than in the non-hypertensive or non-diabetic adults. The prevalence of microalbuminuria was much more frequent in persons with the MetS (36.0%) than the persons without the MetS (5.4%). The levels of FBG, systolic blood pressure (SBP), diastolic blood pressure (DBP) and triglycerides were significantly higher (p < 0.01 for all cases) in subjects with microalbuminuria. In regression analysis, after adjusting for sex, age, and body mass index, microalbuminuria was strongly correlated with MetS followed by elevated BP and FBG (p < 0.01 for all cases). Conclusions Microalbuminuria was strongly associated with MetS in Bangladeshi adults. Elevated BP and FBG were the most predominant components of MetS among the study subjects. Comprehensive management of MetS at its early stage can be effective to prevent and reduce the progression of kidney injury and cardiovascular complications.

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Relationship between serum uric acid and hypertension: a cross-sectional study in Bangladeshi adults

Cited by 75 publications

References 46 publications

Prevalence of elevated liver enzymes and its association with type 2 diabetes: A cross‐sectional study in Bangladeshi adults

Prevalence of elevated liver enzymes and its association with type 2 diabetes: A cross‐sectional study in Bangladeshi adults

Association between serum uric acid and metabolic syndrome: a cross-sectional study in Bangladeshi adults

Association of microalbuminuria with metabolic syndrome: a cross-sectional study in Bangladesh

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