Relationship between single nucleotide polymorphism of interleukin-18 and susceptibility to pulmonary tuberculosis in the Chinese Han population

Han, Moonsik; Yue, Jun; Lian, Yuanyuan; Zhao, Yanlin; Wang, Hongxiu; Liu, Li-rong

doi:10.1111/j.1348-0421.2011.00332.x

Cited by 29 publications

(23 citation statements)

References 33 publications

(30 reference statements)

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“…Carriage of the variant allele in IL18-607 conferred an almost 4-fold increased risk of developing an IRD event in Indian patients, but had no effect in Cambodians. No such association was observed in a cohort of HIV-negative Indian pulmonary TB patients [7], but in a Han Chinese pulmonary TB cohort without HIV, carriage of the variant allele in IL18-607 was associated with a decreased risk of developing TB [6].…”

Section: Discussionmentioning

confidence: 86%

The Search for a Genetic Factor Associating with Immune Restoration Disease in HIV Patients Co-Infected withMycobacterium tuberculosis

et al. 2013

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Abstract. BACKGROUND: Up to 43% of HIV-infected patients co-infected with Mycobacterium tuberculosis experience exacerbations of tuberculosis (TB) after commencing antiretroviral therapy (ART). These are termed immune restoration disease (IRD). It is unclear why individual susceptibility varies. OBJECTIVE: We investigate if single nucleotide polymorphisms (SNP) in genes encoding cytokines, chemokines and their receptors associate with development of an IRD event in patients of two different ethnicities. METHODS: DNA samples were available from small well-characterised groups of HIV patients treated in Cambodia (TB-IRD, n = 17; HIV + TB + controls, n = 55) and India (TB-IRD, n = 19; HIV + TB + controls, n = 43). HIV patients with a TB diagnosis but no evidence of IRD were included to control for susceptibility to TB per se. Sixteen SNP implicated in inflammation or mycobacterial disease were genotyped. RESULTS: Susceptibility to TB-IRD associated with carriage of TNFA-1031*T (rs1799964; P = 0.05) and SLC11A1 D543N*G (rs17235409; P = 0.04) in Cambodian patients and carriage of IL18-607*G (rs1946518; P = 0.02) and VDR FokI (F/f)*T (rs10735810; P = 0.05) in Indian patients. CONCLUSIONS: Associations between polymorphisms in immune-related genes and TB-IRD were found, but none were common across two ethnicities.

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Section: Discussionmentioning

confidence: 86%

The Search for a Genetic Factor Associating with Immune Restoration Disease in HIV Patients Co-Infected withMycobacterium tuberculosis

et al. 2013

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“…[16] Ben-Selam et al [17] reported a significant association between active tuberculosis and RANTES gene 28C/G and 403G/A polymorphisms in a Tunisian population. Han et al [18] also found that IL-18 gene polymorphism was more frequent in patients with tuberculosis in the Chinese population. Hahn [19] found a signifi cant relationship between COPD and C. pneuominia infections.…”

Section: Discussionmentioning

confidence: 93%

Paraoxonase-1 gene in patients with chronic obstructive pulmonary disease investigation Q192R and L55M polymorphisms

Gürbüz¹,

Yıldız²,

Kara³

et al. 2015

World Journal of Emergency Medicine

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BACKGROUND:The effect of increased oxidative stress on the development of chronic obstructive pulmonary disease (COPD) is well known. One of the antioxidative systems against oxidative stress in human body is paraoxonase (PON) enzyme that protects low density lipoproteins (LDL) against oxidation. This study aimed to explore the polymorphisms on PON1, Q192R, L55M genes of patients with COPD.METHODS: DNAs extraction was obtained from blood samples of 50 patients diagnosed with COPD and 50 patients as a control group who were presented to emergency clinic. Genotypes were obtained with polymerase chain reaction (PCR) and AIw I and Hsp92II restriction enzymes were used for Q192R and L55M polymorphisms, respectively. Analysis of data was done with the Chi-square test and Fisher's exact test. RESULTS:A statistically significant difference in Q192R polymorphism was found between the COPD patients and the control group (P=0.05). There was no statistically signifi cant difference in L55M polymorphisms between the patient and control groups (P>0.05). Q192R polymorphism was signifi cantly correlated with the PON1 gene and cigarette smoking; however other risk factors did not show any significant correlation with this polymorphism. Though L55M polymorphism was signifi cantly correlated with family history and tuberculosis, there was no signifi cant correlation with other risk factors. CONCLUSION:We believe that more studies are needed to study the correlation of L55M polymorphism with other factors.

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“…Three SNPs in the promoter of the IL-18 gene at positions −656 G/T, −607 C/A and −137 G/C have been identified. These promoter SNPs have been implicated as susceptibility loci for various diseases, including asthma [22], pulmonary tuberculosis [23], inflammatory bowel disease [24], Parkinson’s disease [25], polycystic ovary syndrome [26], type I diabetes [27], and allergic disorders [28]. …”

Section: Discussionmentioning

confidence: 99%

Association of interleukin-18 gene polymorphism with body mass index in women

Kim

Cho

Kim

et al. 2012

Reprod Biol Endocrinol

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BackgroundInterleukin (IL)-18 is an important regulator of innate and acquired immune responses and has multiple roles in chronic inflammation and autoimmune disorders. Obesity is characterized by low- grade chronic inflammation. IL-18 has been suggested as an adipogenic cytokine that is associated with excess adiposity. The purpose of this study is to evaluate the relationship between IL-18 gene polymorphisms (−137 G/C and −607 C/A) and obesity.MethodsAll 680 subjects were genotyped for the polymorphisms of IL-18 gene promoters (at positions −137 G/C and −607 C/A) using a polymerase chain reaction (271 cases with BMI ≥25 kg/m2 and 409 controls with BMI <25 kg/m2). A chi-square test was used to compare the genotype and allele frequencies between the cases and control populations.ResultsAnalyses of the genotype distributions revealed that IL-18 –607 C/A polymorphism was associated with an increase in body mass index in obese women in the Korean population (chi(2) = 12.301, df = 2, p = 0.015).ConclusionCarriage of the A allele at position −607 in the promoter of the IL-18 gene may have a role in the development of obesity.

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Relationship between single nucleotide polymorphism of interleukin-18 and susceptibility to pulmonary tuberculosis in the Chinese Han population

Cited by 29 publications

References 33 publications

The Search for a Genetic Factor Associating with Immune Restoration Disease in HIV Patients Co-Infected withMycobacterium tuberculosis

The Search for a Genetic Factor Associating with Immune Restoration Disease in HIV Patients Co-Infected withMycobacterium tuberculosis

Paraoxonase-1 gene in patients with chronic obstructive pulmonary disease investigation Q192R and L55M polymorphisms

Association of interleukin-18 gene polymorphism with body mass index in women

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