Relationship between sleep complaints and proinflammatory cytokines in haemodialysis patients

Erten, Yasemin; Köktürk, Oğuz; Yüksel, Aydan; Elbeğ, Şehri; Çiftçi, Tansu Ulukavak; Paşaoğlu, Hatîce; Özkan, Seçil; Bali, Musa; Arinsoi, Turgay; Sindel, Şükrü

doi:10.1111/j.1440-1797.2005.00418.x

Cited by 38 publications

(23 citation statements)

References 39 publications

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“…In addition to melatonin, it has also been suggested that altered cytokine levels have a role in sleep disorders (17). Chronic inflammation, as determined by altered cytokine levels, is highly prevalent in patients with end-stage renal disease (16).…”

Section: Discussionmentioning

confidence: 99%

Sleep pattern in an experimental model of chronic kidney disease

Hirotsu

Tufik²,

Bergamaschi

et al. 2010

American Journal of Physiology-Renal Physiology

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The prevalence of sleep disorders is significantly elevated in chronic kidney disease (CKD) patients. Numerous factors likely contribute to the high prevalence of sleep problems in uremic patients. The objective of this study was to evaluate the long-term sleep pattern changes in uremic rats during disease progression. Sleep recordings of the rats were monitored during light and dark periods that lasted 12 h each. These recordings were performed on days 7, 30, 60, and 90 after CKD induction. Cardiovascular, hormonal, and biochemical changes were evaluated at these same time points in control and uremic rats. CKD progression was reflected by the presence of hypertension and progressive increases in urea, creatinine, and cholesterol levels. We also observed hormonal fluctuations of corticosterone and ACTH, which indicated a potential alteration in the hypothalamic-pituitary-adrenal axis in diseased rats. In addition, rats with CKD demonstrated fragmented sleep with a greater number of arousals and decreased sleep efficiency in the light period during disease progression. In the dark period, there was an initial increase in sleep efficiency in CKD rats, but after 90 days of CKD, these animals slept less compared with the control group. Collectively, these metabolic and cardiovascular changes were associated with the persistent alterations in sleep architecture observed in CKD rats.

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Section: Discussionmentioning

confidence: 99%

Sleep pattern in an experimental model of chronic kidney disease

Hirotsu

Tufik²,

Bergamaschi

et al. 2010

American Journal of Physiology-Renal Physiology

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show abstract

“…Unfortunately much of these data are hard to interpret due to the bidirectional relationship with sleep, and the propensity for the use of cross-sectional studies in this research. For example, the relationship has been extensively studied in dialysis patients, but the study designs make it difficult to tell if sleep disturbances are a consequence or a cause of inflammation (Bilgic et al, 2007;Chiu et al, 2009;Erten et al, 2005;Gul et al, 2006;Lee et al, 2009;Li et al, 2012;Pertosa et al, 2000;Razeghi et al, 2012;Shiohira et al, 2011;Taraz et al, 2013;Yang et al, 2007). In inflammatory bowel disease (IBD), sleep disturbances, including prolonged sleep latency, frequent sleep fragmentation and inefficient sleep are common.…”

Section: Insomnia or Sleep Disturbances And Inflammationmentioning

confidence: 99%

A review of the neuro- and systemic inflammatory responses in post concussion symptoms: Introduction of the “post-inflammatory brain syndrome” PIBS

Rathbone

Tharmaradinam

Jiang

et al. 2015

Brain, Behavior, and Immunity

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“…(4) Psychologic factors: The SF-36 MCS score was used to assess the role of psychologic well-being in sleep quality. (5) Comorbid disease: Patients who undergo dialysis often have substantial comorbidity and exhibit elevated levels of inflammatory markers (38,39), both of which have been associated with reduced sleep quality (40). Therefore, our models examined diabetes; the cause of kidney failure; comorbidity as measured by ICED (21); and fibrinogen, IL-6, and C-reactive protein levels.…”

Section: Selection Of Covariatesmentioning

confidence: 99%

Sleep Quality and Its Correlates in the First Year of Dialysis

Unruh

Buysse

Dew

et al. 2006

Clinical Journal of the American Society of Nephrology

106

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Although sleep problems are thought to be prevalent among patients who undergo dialysis, there is only limited information on the determinants of sleep quality and the change in sleep quality during the first year of dialysis treatment. This report uses data from a national cohort study of incident hemodialysis and peritoneal dialysis patients to identify the correlates of sleep quality and to determine the extent to which sleep quality is related to patients' health-related quality of life and survival. This report includes 909 incident dialysis patients who responded to questions about sleep quality. Three quarters of incident dialysis patients reported impaired sleep, and 14% had a decline in sleep quality in the first year of treatment. Poor sleep quality was significantly related to black race, higher serum phosphate, current smoking, benzodiazepine prescription, and complaints of severe restless legs. Poor baseline sleep quality was associated with lower SF-36 physical and mental component summary scores, vitality scores, and bodily pain scores (all P < 0.001). Younger age, current smoking, and benzodiazepine prescription were associated with decreases in sleep quality at 1 yr. There was no association between baseline sleep quality and survival; however, a decline in sleep quality during the first year on dialysis was associated with shorter survival (hazard ratio 1.44; 95% confidence interval 1.13 to 1.83; P ‫؍‬ 0.003). Future work should examine the link between sleep quality and daytime functioning in the kidney failure population and the extent to which improving sleep quality will improve dialysis patient outcomes.

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Relationship between sleep complaints and proinflammatory cytokines in haemodialysis patients

Abstract: Proinflammatory cytokines, IL-1beta in particular, might be associated with sleep complaints in HD patients. OSAS is not uncommon in HD patients with sleep-related complaints and sleep architecture does not appear to be effected by the HD procedure itself.

Cited by 38 publications

References 39 publications

Sleep pattern in an experimental model of chronic kidney disease

Sleep pattern in an experimental model of chronic kidney disease

A review of the neuro- and systemic inflammatory responses in post concussion symptoms: Introduction of the “post-inflammatory brain syndrome” PIBS

Sleep Quality and Its Correlates in the First Year of Dialysis

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