Relationship between SNP rs1764391 and Susceptibility, Risk Factors, Gene-environment Interactions of Acute Myocardial Infarction in Guangxi Han Chinese Population

Abstract

Background: Large-scale population studies showed that the SNP rs1764391 of Connexin37 gene also known as Cx37 gene may play a pivotal role in the occurrence and development of acute myocardial infarction (AMI). Published results, however, are highly controversial. Objective: This study aimed to examine the association between SNP rs1764391 of Cx37 and diseasesusceptibility, several risk factors, and gene-environment interactions of AMI in Guangxi Han Chinese population. Methods: In this study, 344 healthy controls and 344 AMI patients of Han Chinese population were enrolled. The TaqMan assay was implemented to identify genotypes of Cx37 and allele frequencies of SNP rs1764391 in both the AMI and control groups. Results: Significant differences were detected in TT genotype frequencies of SNP rs1764391 between the AMI and control groups (P < 0.05). In the context of gender stratification, the result was also statistically different in women (P < 0.05). Each variable such as age, BMI, diabetes, high blood pressure, smoking and TC was a risk factor and correlated significantly (P < 0.05) with the development of AMI. HDL-C correlated negatively with the risk of AMI (P < 0.001). BMI, smoking or alcohol consumed interacts significantly (P < 0.017) with the presence of the SNP rs1764391 CC genotype. Conclusions: Evidences were presented that Cx37 rs1764391 variation may contribute to the risk for AMI, especially in women and this genetic variant may prove to be a potential biomarker for AMI risk stratification and may prove to be a useful target for therapeutic intervention to further improve prognosis in high-risk patients.

Gene-diet interactions and cardiovascular diseases: a systematic review of observational and clinical trials

“…By contrast, within the same categories of alcohol intake, carriers of the Cx37 variant rs1764391 with CC genotype had an OR 0.54 (95% CI 0.31, 0.9) [ 38 ]. An increased odds of MI was observed between those consuming ≥ 250 g/day alcohol who carried the rs1764391 CC genotype, rs1746048 CC genotype, and rs11206510 TT genotype, with ORs of 32.7 (95% CI 4.4, 241.6), 24.0 (95% CI 4.9, 116.3), and 14.0 (95% CI 5.1, 42.1), respectively [ 32 , 38 , 41 ]. Additionally, in the same population, carriers of the SLC22A3 variant rs539298 with AG/GG genotype who reported alcohol drinking had an OR 0.53 (95% CI 0.37, 0.77), compared with no drinkers [ 80 ].…”

“…Participants with the rs1746048 CC genotype and rs11206510 TT genotype consuming 0–250 g/day of alcohol had an MI OR of 14 (95% CI 3.2, 61.4) and 9.63 (95% CI 3.7, 24.9), respectively [ 32 , 41 ], compared to non-drinkers. By contrast, within the same categories of alcohol intake, carriers of the Cx37 variant rs1764391 with CC genotype had an OR 0.54 (95% CI 0.31, 0.9) [ 38 ]. An increased odds of MI was observed between those consuming ≥ 250 g/day alcohol who carried the rs1764391 CC genotype, rs1746048 CC genotype, and rs11206510 TT genotype, with ORs of 32.7 (95% CI 4.4, 241.6), 24.0 (95% CI 4.9, 116.3), and 14.0 (95% CI 5.1, 42.1), respectively [ 32 , 38 , 41 ].…”

Gene-diet interactions and cardiovascular diseases: A systematic review of observational and clinical trials

“…Participants with the rs1746048 CC genotype and rs11206510 TT genotype consuming 0-250 g/day of alcohol had an MI OR of 14 (95% CI 3.2, 61.4) and 9.63 (95% CI 3.7, 24.9), respectively 29,38 , compared to non-drinkers. By contrast, within the same categories of alcohol intake, carriers of the Cx37 variant rs1764391 with CC genotype had an OR 0.54 (95% CI 0.31, 0.9) 35 . An increased odds of MI was observed between those consuming ≥250 g/day alcohol who carried the rs1764391 CC genotype, rs1746048 CC genotype, and rs11206510 TT genotype, with ORs of 32.7 (95% CI 4.4, 241.6), 24.0 (95% CI 4.9, 116.3), and 14.0 (95% CI 5.1, 42.1), respectively 29,35,38 .…”

“…By contrast, within the same categories of alcohol intake, carriers of the Cx37 variant rs1764391 with CC genotype had an OR 0.54 (95% CI 0.31, 0.9) 35 . An increased odds of MI was observed between those consuming ≥250 g/day alcohol who carried the rs1764391 CC genotype, rs1746048 CC genotype, and rs11206510 TT genotype, with ORs of 32.7 (95% CI 4.4, 241.6), 24.0 (95% CI 4.9, 116.3), and 14.0 (95% CI 5.1, 42.1), respectively 29,35,38 .…”

Genetic, Molecular, and Cellular Determinants of Sex-Specific Cardiovascular Traits

“…104 Subsequent studies have replicated the results for 2 of these variants. 105 A longitudinal study of 46 candidate genes for CVD in 2200 individuals performed an SNP-sex interaction analysis and identified 3 variants with sex-specific associations with CHD. 106 Finally, a case-control study in 1051 individuals specifically estimated the association between a SCARB1 variant and angiographically determined premature CHD, observing a 1.3-fold risk increase for females only.…”