Relationship between Some Biochemical Measurements and Histopathological Changes in Age-Related Kidney Lesions of Rats

Onoue, Masaharu; Uchida, Kazumi; Takahashi, Tokutaro; Kusano, Nobuo; Mutai, Masahiko

doi:10.1538/expanim1978.27.4_405

“…The origin of these droplets seemed to be the lysosomes, and they seemed to result from material being reabsorbed. From the morphological characteristics, it was concluded that these droplets were eosinophilic bodies rather than hyaline droplets (42,43). Recently, droplets showing similar characteristics were observed in the kidneys of rats given decalin, 2,2,4trimethylpentane, or unleaded gasoline.…”

Section: Study Of Rats Administered Kbro3 In Drinkingmentioning

confidence: 93%

Toxicity and carcinogenicity of potassium bromate--a new renal carcinogen.

Kurokawa

¹

,

Maekawa

²

,

Takahashi

³

et al. 1990

Environ Health Perspect

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Potassium bromate (KBrO3) is an oxidizing agent that has been used as a food additive, mainly in the bread-making process. Although adverse effects are not evident in animals fed bread-based diets made from flour treated with KBrO3, the agent is carcinogenic in rats and nephrotoxic in both man and experimental animals when given orally. It has been demonstrated that KBrO3 induces renal cell tumors, mesotheliomas of the peritoneum, and follicular cell tumors of the thyroid. In addition, experiments aimed at elucidating the mode of carcinogenic action have revealed that KBrO3 is a complete carcinogen, possessing both initiating and promoting activities for rat renal tumorigenesis. However, the potential seems to be weak in mice and hamsters. In contrast to its weak mutagenic activity in microbial assays, KBrO3 showed relatively strong potential inducing chromosome aberrations both in vitro and in vivo. Glutathione and cysteine degrade KBrO3 in vitro; in turn, the KBrO3 has inhibitory effects on inducing lipid peroxidation in the rat kidney. Active oxygen radicals generated from KBrO3 were implicated in its toxic and carcinogenic effects, especially because KBrO3 produced 8-hydroxydeoxyguanosine in the rat kidney. A wide range of data from applications of various analytical methods are now available for risk assessment purposes.ImagesFIGURE 1.FIGURE 2.FIGURE 5.FIGURE 6.FIGURE 7.FIGURE 8.FIGURE 9.FIGURE 10.FIGURE 11.FIGURE 12.

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“…The origin of these droplets seemed to be the lysosomes, and they seemed to result from material being reabsorbed. From the morphological characteristics, it was concluded that these droplets were eosinophilic bodies rather than hyaline droplets (42,43). Recently, droplets showing similar characteristics were observed in the kidneys of rats given decalin, 2,2,4-trimethylpentane, or unleaded gasoline.…”

Section: Subacute Toxicitymentioning

confidence: 93%

Toxicity and Carcinogenicity of Potassium Bromate: A New Renal Carcinogen

Kurokawa¹,

Maekawa²,

Takahashi³

et al. 1990

Environmental Health Perspectives

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Potassium bromate (KBrO3) is an oxidizing agent that has been used as a food additive, mainly in the bread-making process. Although adverse effects are not evident in animals fed bread-based diets made from flour treated with KBrO3, the agent is carcinogenic in rats and nephrotoxic in both man and experimental animals when given orally. It has been demonstrated that KBrO3 induces renal cell tumors, mesotheliomas of the peritoneum, and follicular cell tumors of the thyroid. In addition, experiments aimed at elucidating the mode of carcinogenic action have revealed that KBrO3 is a complete carcinogen, possessing both initiating and promoting activities for rat renal tumorigenesis. However, the potential seems to be weak in mice and hamsters. In contrast to its weak mutagenic activity in microbial assays, KBrO3 showed relatively strong potential inducing chromosome aberrations both in vitro and in vivo. Glutathione and cysteine degrade KBrO3 in vitro; in turn, the KBrO3 has inhibitory effects on inducing lipid peroxidation in the rat kidney. Active oxygen radicals generated from KBrO3 were implicated in its toxic and carcinogenic effects, especially because KBrO3 produced 8-hydroxydeoxyguanosine in the rat kidney. A wide range of data from applications of various analytical methods are now available for risk assessment purposes.

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