Relationship between stress, anxiety, depression and salivary IgA with periodontal disease

Abstract

Psychological stress, if sustained over an extended period of time can have deleterious effects on the body. Psychological stress has been implicated as risk indicators for periodontal disease. So, the aim of the current study was to determine the relationship of stress, anxiety and depression level and salivary IgA with periodontal disease. A total 30 patients who referred to periodontology included to the study and divided into 2 experimental groups. Group control patients do not suffer from any periodontal disease and patients CAL up 3 millimeters or more and BOP in upper teeth (case group). All cases were evaluated for stress, anxiety and depression level by DASS42 test. Salivary samples were obtained using spitting method and IgA level is determined with ELISA. Data was analyzed by 2 and Mendle-hazel tests. The patients suffering from periodontal disease were not encountering higher level of stress and anxiety (P=0.3). People suffering periodontal disease (86.7%) were depressed while 60% of people neither periodontal disease nor depressed (P=0.1). A signifi cant difference detected in salivary IgA level in control group (312.66+107.3) compared to case group (207.95+57.21) (P=0.001). Conclusion: these results suggested a correlation exists between incidence of the periodontal disease and immunity.

Biomarkers common for inflammatory periodontal disease and depression: A systematic review

“…Patients with MD had lower GCF cortisol than controls. Karimi et al. (2017) IgA Saliva Salivary IgA level was lower in patients with periodontal disease (207.9 ​+ ​57.2) vs controls (312.66 ​+ ​107.3 units) (P ​= ​0.001).…”

“… Major depression (Structured Clinical Interview for DSM-IV) +ve MD patients had significantly worse periodontal parameters; dental plaque including gingival inflammation, but not increased clinical attachment level. fair Karimi et al. (2017) , Iran 30: 15 with periodontal disease; 15 healthy controls Dental outpatient, 42.4 ​± ​5.4 ​yrs (cases); 44.5 ​± ​8.4 ​yrs (controls), 40% women Periodontal disease (BOP, CAL, PPD, GI, PI) Self –reported depression (DASS42) +ve 87% with periodontal disease had depression compared with 60% without periodontal disease poor Leira et al.…”

Oral health status of individuals with obsessive‐compulsive disorder considering oral hygiene habits

“…[7][8][9] Anxiety has been found to increase inflammatory biomarkers which in turn damage teeth and periodontal health. [10][11][12] The same physiological mechanism can play a role in individuals with OCD. However, the noteworthy point about individuals with OCD is that they have unique obsessions and compulsions such as cleaning habits and diet plans which may improve or deteriorate their oral health status compared with individuals with other mental disorders or healthy individuals.…”