Relationship between the extent of deep venous thrombosis and the extent of acute pulmonary embolism as assessed by CT angiography

Ghaye, Benoît; Willems, Valérie; Nchimi, Alain; Kouokam, L M; Noukoua, C Tchuisse; Maertelaer, V De; Gevenois, Pierre Alain; Dondelinger, Robert

doi:10.1259/bjr/54005160

Cited by 9 publications

(3 citation statements)

References 35 publications

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“…12 There was also a significant relationship between risk of SVT and risk of DVT, as well as of PE, as others have recently reported. [13][14][15][16] Regarding sex differences, women were confirmed to have strongly and significantly higher rates of SVTs than men.…”

Section: Discussionsupporting

confidence: 52%

Risk marker associations with venous thrombotic events: a cross-sectional analysis

et al. 2014

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ObjectiveTo examine the interrelations among, and risk marker associations for, superficial and deep venous events—superficial venous thrombosis (SVT), deep venous thrombosis (DVT) and pulmonary embolism (PE).DesignCross-sectional analysis.SettingSan Diego, California, USA.Participants2404 men and women aged 40–79 years from four ethnic groups: non-Hispanic White, Hispanic, African-American and Asian. The study sample was drawn from current and former staff and employees of the University of California, San Diego and their spouses/significant others.Outcome measuresSuperficial and deep venous events, specifically SVT, DVT, PE and combined deep venous events (DVE) comprising DVT and PE.ResultsSignificant correlates on multivariable analysis were, for SVT: female sex, ethnicity (African-American=protective), lower educational attainment, immobility and family history of varicose veins. For DVT and DVE, significant correlates included: heavy smoking, immobility and family history of DVEs (borderline for DVE). For PE, significant predictors included immobility and, in contrast to DVT, blood pressure (BP, systolic or diastolic). In women, oestrogen use duration for hormone replacement therapy, in all and among oestrogen users, predicted PE and DVE, respectively.ConclusionsThese findings fortify evidence for known risk correlates/predictors for venous disease, such as family history, hormone use and immobility. New risk associations are shown. Striking among these is an association of PE, but not DVT, to elevated BP: we conjecture PE may serve as cause rather than consequence. Future studies should evaluate the temporal direction of this association. Oxidative stress and cell energy compromise are proposed to explain and predict many risk factors, operating through cell-death mediated triggering of coagulation activation.

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Section: Discussionsupporting

confidence: 52%

Risk marker associations with venous thrombotic events: a cross-sectional analysis

et al. 2014

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“…9 Furthermore, the hypothesis that large pulmonary arteries are more likely to be obstructed by emboli originating from large veins was not confi rmed in a quantitative study using the PE clot load score on CTPA and the DVT clot load score on CTV. 10 However, in general, it should be noted that there is no correlation between the clinical severity of PE and the shape or distribution of intrapulmonary thrombus. In addition to the fi ndings of clinical imaging, clinical risk markers, such as the presence of shock, hypotension, right ventricular dysfunc- tion, and myocardial damage, should be considered when estimating the possibility of PE-related early mortality.…”

Section: Discussionmentioning

confidence: 99%

Correlation between the site of pulmonary embolism and the extent of deep vein thrombosis: evaluation by computed tomography pulmonary angiography and computed tomography venography

et al. 2011

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“…It could be speculated that different times between CT scans were responsible for these results. Similarly, a previous study showed that the extent of PE was positively associated with a higher probability of residual DVT 24 , although in another study, the clot burden of PE was not found to necessarily indicate that of DVT 25 .…”

Section: Discussionmentioning

confidence: 69%

Detection of Deep Vein Thrombosis by Follow-up Indirect Computed Tomography Venography after Pulmonary Embolism

et al. 2018

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BackgroundInformation regarding the incidence and risk factors for deep vein thrombosis (DVT) detected by follow-up computed tomographic (CT) venography after pulmonary embolism (PE) is sparse. The aim of the present study was to identify the predictors of DVT in follow-up CT images, and to elucidate their clinical significance.MethodsPatients with PE were classified into the following three cohorts based on the time of indirect CT venography follow-up: within 1 month, 1 to 3 months, and 3 to 9 months after the initial CT scan. Each cohort was subdivided into patients with or without DVT detected by follow-up CT. Clinical variables were compared between the two groups.ResultsFollow-up CT revealed DVT in 61% of patients with PE within 1 month, in 15% of patients with PE at 1 to 3 months, and in 9% of patients with PE at 3 to 9 months after the initial CT scan. Right ventricular (RV) dilation on the initial CT (odds ratio [OR], 8.30; 95% confidence interval [CI], 1.89–36.40; p=0.005) and proximal DVT at the initial presentation (OR, 6.93; 95% CI, 1.90–25.20; p=0.003) were found to independently predict DVT in follow-up CT images within 1 month, proximal DVT at the initial presentation was found to independently predict DVT in follow-up CT images at 1 to 3 months (OR, 6.69; 95% CI, 1.53–29.23; p=0.012), and central PE was found to independently predict DVT in follow-up CT images at 3 to 9 months (OR, 4.25; 95% CI, 1.22–4.83; p=0.023) after the initial CT scan. Furthermore, the detection of DVT by follow-up CT independently predicted the recurrence of venous thromboembolism (VTE) (OR, 4.67; 95% CI, 2.24–9.74; p<0.001).ConclusionThree months after PE, DVT was not detected by follow-up CT in most patients with PE. RV dilation on the initial CT, central PE, and proximal DVT at the initial presentation were found to predict DVT on follow-up CT, which might predict VTE recurrence.

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Relationship between the extent of deep venous thrombosis and the extent of acute pulmonary embolism as assessed by CT angiography

Cited by 9 publications

References 35 publications

Risk marker associations with venous thrombotic events: a cross-sectional analysis

Risk marker associations with venous thrombotic events: a cross-sectional analysis

Correlation between the site of pulmonary embolism and the extent of deep vein thrombosis: evaluation by computed tomography pulmonary angiography and computed tomography venography

Detection of Deep Vein Thrombosis by Follow-up Indirect Computed Tomography Venography after Pulmonary Embolism

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