Relationship between the rewarding and aversive effects of morphine and amphetamine in individual subjects

Verendeev, Andrey; Riley, Anthony L.

doi:10.3758/s13420-011-0035-5

Cited by 47 publications

(36 citation statements)

References 24 publications

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“…First, given the recently reported motor sensitizing effects of cathinone pre-exposure (see Berquist et al, 2016; Gregg et al, 2013; Watterson et al, 2015), such a history could also impact MDPV’s rewarding effects (e.g., changes in MDPV-induced place preference conditioning) and until these assessments are made it is impossible to predict the direction of change in the overall balance and how the change might impact the drug’s self-administration. This is especially relevant given that the aversive and rewarding effects of drugs appear to be dissociable, i.e., changes in one effect is not necessarily paralleled by changes in the other (see Simpson and Riley, 2005; Verendeev and Riley, 2011; for a review, see Verendeev and Riley, 2012). Secondly, independent assessments of changes in drug intake need to be directly made, i.e., the effects of drug history on MDPV self-administration must be assessed to determine the potential for increased and/or escalated use.…”

Section: Discussionmentioning

confidence: 99%

Effects of 3,4-methylenedioxypyrovalerone (MDPV) pre-exposure on the aversive effects of MDPV, cocaine and lithium chloride: Implications for abuse vulnerability

Woloshchuk

Nelson

Rice

et al. 2016

Drug and Alcohol Dependence

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Background Drug use is thought to be a balance of the rewarding and aversive effects of drugs. Understanding how various factors impact these properties and their relative balance may provide insight into their abuse potential. In this context, the present study attempted to evaluate the effects of drug history on the aversive effects of 3,4-methylenedioxypyrovalerone (MDPV), one of a variety of synthetic cathinones (collectively known as “bath salts”). Methods Different groups of male Sprague-Dawley rats were exposed to either vehicle or MDPV (1.8 mg/kg) once every fourth day for five total injections prior to taste avoidance conditioning in which a novel saccharin solution was repeatedly paired with either vehicle, MDPV (1.8 mg/kg), the related psychostimulant cocaine (18 mg/kg) or the emetic lithium chloride (LiCl) (13.65 mg/kg). Results In animals pre-exposed to vehicle, all three drugs induced significant and comparable taste avoidance relative to animals injected with vehicle during conditioning. MDPV pre-exposure attenuated the avoidance induced by both MDPV and cocaine (greater attenuation for MDPV than cocaine), but had no effect on that induced by LiCl. Conclusions These findings suggest that a history of MDPV use may reduce or attenuate MDPV and cocaine’s (but not LiCl’s) aversive effects. The implications for such changes in MDPV’s aversive effects to its potential use and abuse were discussed.

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Section: Discussionmentioning

confidence: 99%

Effects of 3,4-methylenedioxypyrovalerone (MDPV) pre-exposure on the aversive effects of MDPV, cocaine and lithium chloride: Implications for abuse vulnerability

Woloshchuk

Nelson

Rice

et al. 2016

Drug and Alcohol Dependence

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“…On the other hand, in non-feeding situations, the very same drug of abuse might be self-administered and its rewarding properties support the development of, for example, a conditioned place preference (e.g., Berger, 1972; Reicher & Holman, 1977; Wise, Yokel & DeWit, 1976). Furthermore, these two very different behavioral outcomes, a taste aversion and a place preference, can be produced concurrently by the same drug injection (Verendeev & Riley, 2011; Wang, Huang, & Hsiao, 2010). …”

Section: Discussionmentioning

confidence: 99%

Reduced palatability in drug-induced taste aversion: II. Aversive and rewarding unconditioned stimuli.

Arthurs

Lin

Amodeo

et al. 2012

Behavioral Neuroscience

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Drugs of abuse are known to reduce intake of a taste conditioned stimulus (CS), a behavioral response sometimes seen as paradoxical because the same drugs also serve as rewards in other behavioral procedures. In the present study we compared patterns of intake and palatability (assessed using microstructural analysis of licking) for a standard saccharin CS paired with: lithium chloride, morphine, amphetamine, or sucrose. We found that morphine and amphetamine, like lithium-induced illness, each suppressed CS intake and caused a reduction in saccharin palatability. Sucrose, a rewarding stimulus, did not reduce the palatability of the saccharin CS. We interpret these finds as evidence that drugs of abuse induce conditioned taste aversions.

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“…This phenomenon, referred to as reward comparison, was described by Grigson (1997) and is thought to be similar to the anticipatory contrast effect in which rats avoid intake of the same saccharin cue when it predicts the opportunity to consume a highly rewarding sucrose solution [8–10]. In support, reward-sensitive Lewis rats are more sensitive to the suppressive effects of cocaine and sucrose, but not LiCl, than are less sensitive Fischer 344 rats [11–13]. In Sprague-Dawley rats, a history of treatment with chronic morphine leads to greater avoidance of a taste cue paired with cocaine or sucrose, but not the aversive agent, LiCl [14].…”

Section: 1 Introductionmentioning

confidence: 90%

Prior access to a sweet is more protective against cocaine self-administration in female rats than in male rats

Cason

Grigson

2013

Physiology & Behavior

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It is well established that female rats are more sensitive than male rats to the reinforcing effects of cocaine (Lynch, 2008 for review). We hypothesized that greater preference for cocaine would support greater avoidance of a cocaine-paired taste cue in female vs. male rats. Moreover, at least in male rats, greater avoidance of the taste cue is associated with greater cocaine self-administration (Grigson & Twining, 2002). Thus, we anticipated that female rats would not only demonstrate greater avoidance of the drug-paired taste cue, but greater drug-taking as well. We tested these hypotheses by examining avoidance of a saccharin cue in male and female rats following several pairings with self-administered saline or cocaine (0.16, 0.33, or 0.66 mg/infusion). Contrary to expectations, the results showed that female rats exhibited less avoidance of the cocaine-associated saccharin cue than male rats and self-administered less, rather than more, cocaine, Thus, while female rats reportedly take more drug than male rats when the drug is presented in the absence of an alternative reward, they take less drug than male rats when the opportunity to self-administer cocaine is preceded by access to a palatable sweet. Females, then, may not simply be more sensitive to the rewarding properties of drug, but also to the reinforcing properties of natural rewards and this increase in sensitivity to sweets may serve to protect against drug-taking behavior.

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Relationship between the rewarding and aversive effects of morphine and amphetamine in individual subjects

Cited by 47 publications

References 24 publications

Effects of 3,4-methylenedioxypyrovalerone (MDPV) pre-exposure on the aversive effects of MDPV, cocaine and lithium chloride: Implications for abuse vulnerability

Effects of 3,4-methylenedioxypyrovalerone (MDPV) pre-exposure on the aversive effects of MDPV, cocaine and lithium chloride: Implications for abuse vulnerability

Reduced palatability in drug-induced taste aversion: II. Aversive and rewarding unconditioned stimuli.

Prior access to a sweet is more protective against cocaine self-administration in female rats than in male rats

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