Chronic venous diseases of the lower limbs are one of the common and disabling conditions with clinical signs and symptoms ranging from spider veins, to varicose veins or even to venous ulceration, effecting patient's quality of life negatively, particularly in relation to the domains of pain, physical function and mobility. It is not only a serious medical condition but also an undeniable physical and psychosocial problem and has a severe impact on a patient's quality of life. Quality of life is defined as individuals' perception of their position in life and refers to the patient's ability to enjoy normal life activities. It is a common and subjective term that has a number of dimensions described as patient-reported outcomes. There are numerous factors that affect person's quality of life negatively. Some of those are social relationships, economic status, physical health, psychological status, environmental conditions (living place or work), pain and especially chronic diseases. We conducted a review about quality of life in chronic venous diseases of the lower limbs to identify how person's quality of life is affected. Therefore, this chapter will focus on the effect of the chronic venous diseases on the person's quality of life.