Relationship between the sensation of activity limitation and the results of functional assessment in asthma patients

Vermeulen, François; Chirumberro, Audrey; Rummens, Peter; Bruyneel, Marie; Ninane, Vincent

doi:10.1080/02770903.2016.1242138

Cited by 14 publications

(7 citation statements)

References 57 publications

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“…We found a significant correlation between SPD and depression and anxiety scores in our asthma patients, although, interestingly, only age, anxiety, and FEV 1 showed significant associations with the number of SPD. Similarly, Vermeulen et al recently reported that psychological burden was the major activity‐limiting factor for asthma patients . According to Herrmann, it is unlikely that age affects HADS scores.…”

Section: Discussionmentioning

confidence: 97%

Factors associated with daily life physical activity in patients with asthma

Hennegrave

Fry

Behal

et al. 2018

Health Science Reports

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Section: Discussionmentioning

confidence: 97%

Factors associated with daily life physical activity in patients with asthma

Hennegrave

Fry

Behal

et al. 2018

Health Science Reports

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“…1 CRS is a clinically challenging disease; as in asthmatic patients, symptoms lack good correlation with objective measurements because of the lack of a gold standard. 2,3 This might be caused by an underlying variation of endotypes leading to a common phenotype 4 and results in a discrepancy of estimates of prevalence based on either symptoms or objective measures. 5 Current data on the prevalence of CRS based on the EPOS symptombased definition show a prevalence of 5.5% in Brazil, 6 8% in China, 7 11% in Europe 8 and Korea, 9 and 12% in the United States.…”

mentioning

confidence: 99%

Prevalence of chronic rhinosinusitis in the general population based on sinus radiology and symptomatology

Loos

Lourijsen

Wildeman

et al. 2019

Journal of Allergy and Clinical Immunology

190

119

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Background: The prevalence of chronic rhinosinusitis (CRS) measured in epidemiologic studies is 5% to 12%. This might be an overestimation because of overlap with other diseases, such as allergic rhinitis. Objective: We aimed to calculate the prevalence of CRS using a combination of epidemiologically based CRS according to the European Position Paper on Rhinosinusitis and Nasal Polyps (EPOS) together with sinonasal opacification on imaging. Methods: Subjects who underwent a computed tomographic or magnetic resonance imaging scan of the head for any nonrhinologic indication were asked to fill in the Global Allergy and Asthma European Network survey containing EPOS symptom criteria. The scans were evaluated according to the Lund-Mackay (LM) scoring system. Epidemiologically based CRS is based on nasal symptoms according to EPOS; clinically based CRS also encompasses endoscopy and/or CT scanning. Results: Eight hundred thirty-four subjects were included. One hundred seven (12.8%) had epidemiologically based CRS according to EPOS. Of these subjects, 50% had an LM score of 0, 26% had an LM score of 1 to 3, and 23% had an LM score of 4 or greater. Twenty-five (3.0%) subjects had clinically based CRS (based on LM score > _4), and 53 (6.4%) subjects had clinically based CRS (based on LM score >0). Allergic rhinitis was reported by 167 (20%) subjects. In subjects who did not report upper airway symptoms, 57% had an LM score of 0, 30% had an LM score of 1 to 3, and 12% had an LM score of 4 or greater. Conclusion: We found a prevalence of 3.0% to 6.4% of clinically based CRS (depending on an LM cutoff point; ie, LM > _ 4 or LM > 0, respectively) in a relatively randomly selected group of subjects.

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“…Activity limitation is more common in FE (OR 3.2) than nFE patients, where patients classified as hFE had the highest probability (OR 3.8). In this context, it should be taken into consideration that there is a psychological component that can increase the intensity of the perceived limitation [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

Clinical Characterization of the Frequent Exacerbator Phenotype in Asthma

Sprio

Carriero

Levra

et al. 2020

JCM

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Background: Asthma exacerbation is episodic worsening of respiratory symptoms in conjunction with the deterioration of lung function, which may occur independently from the asthma severity hampering asthmatics’ quality of life. This study aimed to characterize the patient phenotype more prone to asthma exacerbation (oral corticosteroid burst ≥2 per year) to allow the proper identification of such patients. Methods: This real-life, observational, cross-sectional study evaluated 464 asthmatic patients stratified according to the asthma exacerbations experienced in the previous year. Clinical, functional, and blood parameters were retrieved from chart data and were representative of patients in stable conditions. Results: The frequent asthma exacerbator was more commonly female, suffered from chronic rhinosinusitis with nasal polyposis, had reduced lung function and peripheral oxygen saturation, and had increased daily activity limitations. These patients often had severe asthma and more frequently needed hospitalization in their lives. Furthermore, the frequent asthma exacerbator had higher concentrations of serum immunoglobulin E (IgE) and exhaled nitric oxide with cut-off risk values of 107.5 kU/L (OR = 4.1) and 43.35 ppb (OR = 3.8), respectively. Conclusions: This study illustrates the clinical features of the frequent asthma exacerbator phenotype. Nevertheless, serum IgE and exhaled nitric oxide could allow the identification of this phenotype and the establishment of an appropriate therapeutic approach.

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Relationship between the sensation of activity limitation and the results of functional assessment in asthma patients

Abstract: In response to questions about limitation of activity, patients do not specifically answer mentioning physical limitation but rather the psychological burden associated with this constraint.

Cited by 14 publications

References 57 publications

Factors associated with daily life physical activity in patients with asthma

Factors associated with daily life physical activity in patients with asthma

Prevalence of chronic rhinosinusitis in the general population based on sinus radiology and symptomatology

Clinical Characterization of the Frequent Exacerbator Phenotype in Asthma

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