Relationship Between the Severity of Penile Curvature and the Presence of Comorbidities in Men With Peyronie's Disease

Usta, Mustafa F.; Bivalacqua, Trinity J.; Jabren, George W.; Myers, Leann; Sanabria, Jose; Sikka, Suresh C.; Hellstrom, Wayne J.G.

doi:10.1097/01.ju.0000097498.34847.7c

Cited by 50 publications

(52 citation statements)

References 19 publications

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“…Apart from Dupuytren's disease, Rhoden et al [17] and Usta et al [4] did not find an association between PD and these comorbid conditions. Apart from Dupuytren's disease, Rhoden et al [17] and Usta et al [4] did not find an association between PD and these comorbid conditions.…”

Section: Introductionmentioning

confidence: 90%

“…PD has a prevalence rate of 3%; however, the prevalence may be higher due to a limited reporting of the disorder, as patients are embarrassed or unaware of their condition [1][2][3]. Less commonly the plaques are laterally located causing lateral deflections [4,5]. Plaques are usually dorsally located causing upward deflection of the penis.…”

Section: Introductionmentioning

confidence: 99%

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The role of testosterone deficiency in the development of Peyronie’s disease and its role in the severity of the disease manifestations

Roaiah¹,

Hassanin²,

Aal³

et al. 2015

Human Andrology

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PurposeBoth Peyronie's disease (PD) and late onset hypogonadism occur, most likely, in middle-aged and old men. It is well-known that testosterone declines with age and is implicated in wound healing; therefore, the role of testosterone deficiency in the development and severity of PD was investigated. Patients and methods A prospective controlled study was carried out on 25 participants, 15 with PD and 10 controls. PD patient history questionnaire was obtained, and PD was later confirmed by physical examination. The total and free serum testosterone levels were estimated. Evaluation of the differences between the two groups was carried out. In PD patients, the plaque area and penile curvature were assessed. PD patients were further classified into two subgroups: subgroup A (low testosterone level) and subgroup B (normal testosterone level). Evaluation of the differences between the two subgroups, such as the plaque area and penile curvature, was carried out. ResultsA significantly lower free and total serum testosterone levels were found in the PD patient group compared with the control group (Po0.05). Moreover, it was found that 60% of patients with PD had low serum testosterone levels. On comparing the subgroups, the plaque size was found to be significantly larger and the mean degree of penile curvature was found to be significantly greater in subgroup A. ConclusionTestosterone deficiency may play a role in the development of PD and in the development of more severe manifestations of the disease, such as plaque size and penile curvature. However, further studies with larger samples are encouraged to confirm these conclusions.

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Section: Introductionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

The role of testosterone deficiency in the development of Peyronie’s disease and its role in the severity of the disease manifestations

Roaiah¹,

Hassanin²,

Aal³

et al. 2015

Human Andrology

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“…49,50 Therefore, if Peyronie's disease is present, patients should be tested for diabetes. 49,50 Therefore, if Peyronie's disease is present, patients should be tested for diabetes.…”

Section: Pathophysiology Of Male Sexual Dysfunctionmentioning

confidence: 99%

Diabetes and Quality of Life

Pozzo¹,

Mociulsky²,

Martínez

et al. 2016

American Journal of Therapeutics

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The different aspects that contribute to quality of life in patients with diabetes mellitus, such as mood, are of great importance for the treatment of this disease. These aspects not only influence the well-being of patients but also influence treatment adherence, therefore affecting the course of the disease. A panel of experts from Argentina, Chile, and Uruguay performed a review of the main aspects affecting quality of life in patients with diabetes: physical activity, mood disorders, and sexual activity. The consensus of the panel was that physical activity is important in the treatment of patients with diabetes because it reduces morbidity, mortality, and disease complications, and it should be performed on a regular basis, bearing in mind the patient's characteristics. Increased physical activity is associated with better glycemic control, and in individuals with glucose intolerance, it delays progression toward diabetes. In patients with diabetes, there is a high prevalence of depression, which can influence treatment adherence. Therefore, early detection of depression is essential to improve the course of diabetes. Regarding sexual activity, erectile dysfunction may be a significant sign in the case of suspected diabetes and the early diagnosis of vasculopathy in patients with diabetes. In conclusion, greater emphasis should be placed on improving patient knowledge, early detection, and multidisciplinary approaches to deal with the aspects of diabetes that affect patients' quality of life.

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“…and 3 ('Did your erection last long enough for you to have successful intercourse?'). EF was categorized as follows using the IIEF-5 total scores: no ED (22)(23)(24)(25), mild ED (17-21), mild to moderate ED (12)(13)(14)(15)(16), moderate ED (8-11) and severe ED (5-7). 19,20 Presence and severity of painful erections was determined on a conventional 10-point visual analog pain scale (VAS) score ranging from 0 to 10, with 0 being no pain and 10 being severe pain.…”

Section: Evaluationsmentioning

confidence: 99%

Safety and efficacy of coenzyme Q10 supplementation in early chronic Peyronie's disease: a double-blind, placebo-controlled randomized study

Safarinejad¹

2010

Int J Impot Res

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Relationship Between the Severity of Penile Curvature and the Presence of Comorbidities in Men With Peyronie's Disease

Cited by 50 publications

References 19 publications

The role of testosterone deficiency in the development of Peyronie’s disease and its role in the severity of the disease manifestations

The role of testosterone deficiency in the development of Peyronie’s disease and its role in the severity of the disease manifestations

Diabetes and Quality of Life

Safety and efficacy of coenzyme Q10 supplementation in early chronic Peyronie's disease: a double-blind, placebo-controlled randomized study

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