Relationship between the usability and physicochemical properties of triamcinolone acetonide ointments

Abstract

The purpose of this study was to examine the physicochemical properties of TA ointments and conduct a human sensory test to assess the properties of those ointments. Physicochemical assessment was done via near-infrared (NIR) absorption spectroscopy, measurement of water content, microscopy, and measurement of viscoelasticity. The human sensory test examined 5 aspects (texture, cohesiveness, spreadability, smell, and feel). Three TA ointments were used: TA-A, a brand-name preparation, and TA-B and TA-C, two generics. The sensory test revealed significant differences between TA-A and TA-B and TA-C in terms of cohesiveness and spreadability. Significant differences between TA-A and TA-C and between TA-B and TA-C in terms of feel were noted. Microscopic examination revealed that TA-C had good dispersibility while TA-A and TA-B produced crystallization. NIR spectroscopy revealed differences in absorption spectra attributed to oil and water content in TAA, TA-B, and TA-C. Measurement of water content indicated water content of 0.06 ± 0.02% for TA-A, 0.08 ± 0.08% for TA-B, and 36.7 ± 1.19% for TA-C. Assessment of viscoelasticity indicated that stress decreased for all 3 ointments at 35 °C compared to that at 25 °C. TA-A and TA-B were found to have a higher percent decrease in stress than was TA-C. These findings indicate that differences in the types and content of additives caused differences in the physicochemical properties of individual ointments. In addition, differences in physicochemical properties presumably resulted in the close correlation between cohesiveness and spreadability in the sensory test.

Development, Physical-Chemical Characterization and in Vitro Antibacterial Activity Evaluation of a Fixed-Dose Combination Isohydrafural-Methyluracil Hydrophilic Ointment

“…The formulation with the most optimal viscosity at 22°C could be easily removed from the container, while the most optimal viscosity at 37°C will allow an easier application on the wounds [35][36][37][38][39][40]. An optimal osmosis, which should be within the limits 250 -300%, will eliminate the exudate and also, will not affect the epithelisation phases [13].…”

Measurement of the Water Content in Semi-solid Formulations Used to Treat Pressure Ulcers and Evaluation of Their Water Absorption Characteristics

“…On the other hand, NIRS has recently been used quantitatively in the quality control of pharmaceutical preparations, [9][10][11][12][13][14][15][16][17] quantification of active pharmaceutical ingredients or excipients, 12,15,16) and measurement of the water content in food, pharmaceutical, and industrial products. 9,10,[18][19][20]22) NIRS is more advantageous and user-friendly than KF as it is a simple, rapid, nondestructive analytical method.…”

Comparison of various pharmaceutical properties of clobetasol propionate cream formulations - considering stability of mixture with moisturizer-

“…Near infrared (NIR) spectroscopy is frequently used for non-destructive analyses of food, agricultural products, and beverages [3][4][5][6][7]. NIR spectroscopy is also used in pharmaceutical sciences for applications, such as (i) qualitative validation of the components of dermatological formulations, ointments, or creams [8][9][10][11]; (ii) assessment of the degree of mixing of powders prepared by using a mortar and pestle, fine granules, and dry syrups [12]; and (iii) assessment of the distribution of the active pharmaceutical ingredient (API) and excipients in tablets by using microscopic NIR spectroscopy, which combines microscopy and NIR spectroscopy [13,14]. Recently, we evaluated a CLB Cr using NIR spectroscopy.…”