Relationship between uric acid and blood pressure in different age groups

Lee, Jae Joong; Ahn, Jeonghoon; Hwang, Jinseub; Han, Seong Woo; Lee, Kwang No; Kim, Ji Bak; Lee, Sunki; Na, Jin Oh; Lim, Hong Euy; Kim, Jin Won; Rha, Seung Woon; Park, Chang Gyu; Seo, Hong Seog; Oh, Dong Joo; Kim, Eung Ju

doi:10.1186/s40885-015-0022-9

Cited by 67 publications

(72 citation statements)

References 33 publications

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“…The association between SUA and BP is not as strongly supported in the elderly population, and SUA-lowering agents have different effects on controlling BP in the elderly and in the young adults with hyper-uricemia [22,23]. However, large controlled studies are needed to formally establish the effect of SUA lowering on BP control and on hard cardiovascular and renal endpoints.…”

Section: Discussionmentioning

confidence: 99%

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Asymptomatic hyperuricemia is a strong risk factor for resistant hypertension in elderly subjects from general population

Mazza

Lenti

Schiavon

et al. 2017

Biomedicine & Pharmacotherapy

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Objective In clinical practice, patient characteristics predicting resistant hypertension (RH) include higher blood pressure levels, left ventricular hypertrophy, older age, obesity, chronic kidney disease and diabetes. On the contrary little is known about the role of serum uric acid (SUA) as a risk factor for RH in subjects from general population. Material and methods 580 elderly subjects aged ≥65 years were enrolled in the Risk Of Vascular complications Impact of Genetics in Old people (ROVIGO) study. RH was defined as the failure to maintain blood pressure values below 140 mmHg (systolic) and 90 mmHg (diastolic) despite therapeutic interventions that include appropriate lifestyle measures plus adherence to treatment with full doses of at least three antihypertensive drugs, including a diuretic. RH was confirmed using 24-h ambulatory blood pressure measurement. Hyperuricemic was defined as the subjects having SUA ≥6.8 mg/dl or taking uricosuric drugs. Gender-specific odds ratio (OR) for RH was calculated by logistic regression analysis. Results The prevalence of RH was 5.7% in the cohort and was higher in women (8.3%) than in men (3.0%, p < 0.05). Independent of chronic kidney disease (OR 3.89, 95% confidence interval 1.49–10.1), hyperuricemia predicted resistant hypertension in women (odds ratio 3.11, 95% confidence intervals 1.06–9.1, p = 0.03) but not in men. Conclusions In elderly women from the general population, an SUA value of ≥6.8 mg/dl triples the risk of RH. SUA assessment should be recommended to better define the pattern of risk associated with RH.

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Section: Discussionmentioning

confidence: 99%

“…Age was an independent predictor for the elevation of SUA, and it is well known that the relationship between age and the occurrence of hyperuricemia differs between men and women [23]. Hyperuricemia correlates negatively with age in men but positively in women [24,25], possibly due to sex hormonal interactions [26].…”

Section: Discussionmentioning

confidence: 99%

Asymptomatic hyperuricemia is a strong risk factor for resistant hypertension in elderly subjects from general population

Mazza

Lenti

Schiavon

et al. 2017

Biomedicine & Pharmacotherapy

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“…The higher the SUA within the normal range, the greater was the risk to develop Htn [36]. The association between high SUA and Htn is stronger in younger ages and in females [37], [38]. High SUA is one of the major predictors of worse BP control [39], [40], [41], [42].…”

Section: Uric Acid and Metabolic Syndromementioning

confidence: 99%

Uric acid in the pathogenesis of metabolic, renal, and cardiovascular diseases: A review

Din

Salem

Abdulazim

2017

Journal of Advanced Research

308

165

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“…Our study showed that T2DM subjects who had hyperuricemia was 42%. Another study shows 33% population with hypertension had high serum uric acid level 21 . A study of our country observed 25.4% of study populations had hyperuricemia with hypertension 20 .…”

Section: Discussionmentioning

confidence: 97%

Relationship Between Uric Acid Level and Blood Pressure in T2DM Patient Attending in BIRDEM General Hospital

Ferdous

Begum

Muttalib

2018

Bangladesh J Med Biochem

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IntroductionHyperuricemia is becoming an increasing problem all over the world with a steady increase in prevalence 4 . Many factors contribute to hyperuricemia eg: genetics, insulin resistance, hypertension, renal insufficiency, obesity, diet, use of diuretics, and consumption of alcoholic beverages 3 . Some experimental and clinical studies suggest that uric acid has a contributory role in the pathogenesis of elevated blood pressure by several mechanisms such as inflammation, vascular smooth muscle cell proliferation in renal microcirculation, and activation of renin-angiotensin-aldosterone system 7 . Another study showed high arterial tension in gout due to higher level of uric acid in the blood increases tone of arterioles causing hypertension 8 . Several recent small clinical trials have demonstrated that serum uric acid lowering agents such as allopurinol and probenecid can reduce blood pressure (BP) in adolescents 9 . Some studies also showed that the subjects with higher levels of serum uric acid are more at risk of developing type 2 diabetes and it was also found that one-quarter of diabetic cases can be attributed to a high serum uric acid level 10 . Recent studies have introduced serum uric acid as a potential risk factor for hypertension, stroke and cardiovascular diseases [11][12][13] . A study showed the prevalence of hyperuricemia to be 33% of RELATIONSHIP BETWEEN URIC ACID LEVEL AND BLOOD PRESSURE IN T2DM PATIENTS ATTENDING THE BIRDEM GENERAL HOSPITAL ABSTRACTHyperuricemia is associated with higher mortality in patients suffering from hypertension, coronary heart disease, cerebrovascular events, metabolic syndrome, insulin resistance, gout and renal stone formation and it is more in individuals with diabetes. The prevalence of hyperuricemia is high in T2DM. The aim of the present study was to assess the relationship between hyperuricemia and blood pressure in T2DM subjects and thus to help the clinician for early diagnosis, treatment and to prevent further complications. Total 350 study subjects were enrolled for this study; among them 203 were T2DM with normal level of serum uric acid level and 147 were T2DM with high serum uric acid level. It was observed that systolic blood pressure was significantly higher (134.5±9.6 mm of Hg) in T2DM with hyperuricemia (p<0.001) than T2DM with normal serum uric acid level (123.3±10.9 mm of Hg). On the other hand diastolic blood pressure was significantly higher (87.1±5.9 mm of Hg) in T2DM with hyperuricemia (p<0.001) than T2DM with normal serum uric acid level (79.6±8.3 mm of Hg). Age (years) showed no significant difference between T2DM with serum uric acid<7 mg/dl and T2DM with serum uric acid>7 mg/dl (p<0.05). In our study it was revealed that males were in greater risk of developing hyperuricemia. BMI was significantly (p<0.001) greater in T2DM subjects who had normal serum uric acid level (27.9±3.8) than with those who had serum uric acid>7 mg/dl (24.4±3.83). No significant differences were found in FBS, blood sugar 2 hours after breakfast, HbA1C, seru...

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Relationship between uric acid and blood pressure in different age groups

Cited by 67 publications

References 33 publications

Asymptomatic hyperuricemia is a strong risk factor for resistant hypertension in elderly subjects from general population

Asymptomatic hyperuricemia is a strong risk factor for resistant hypertension in elderly subjects from general population

Uric acid in the pathogenesis of metabolic, renal, and cardiovascular diseases: A review

Relationship Between Uric Acid Level and Blood Pressure in T2DM Patient Attending in BIRDEM General Hospital

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