Relationship between viral antibodies and bronchial hyperresponsiveness in 495 unselected children and adolescents

Backer, Vibeke; Ulrik, Charlotte Suppli; Bach‐Mortensen, N.; Glikmann, Graciela; Mordhorst, Carl H.

doi:10.1111/j.1398-9995.1993.tb00723.x

Cited by 6 publications

(3 citation statements)

References 30 publications

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“…According to our investigation, the effect of RSV modulation on aeroallergen sensitization of non hospitalized infants does not persist into the second year of life. From this age onward, the risk of sensitization resulting from an atopic family history clearly overrides the risk due to RSV infection (7,19,23). For this reason, we and other authors (11,24) have been unable to detect any modifying effect of RSV infection, when looking for the atopic manifestations during infancy and early childhood which depend for the most part on sensitization to ingested allergens.…”

Section: Discussionmentioning

confidence: 82%

Respiratory syncytial virus infection: its role in aeroallergen sensitization during the first two years of life

Förster

Tacke

Krebs

et al. 1996

Pediatric Allergy Immunology

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Our aim was to study the influence of infection with the respiratory syncytial virus (RSV) in non-hospitalized infants on sensitization to aeroallergens and the early manifestation of atopy. Six hundred and nine infants from the prospective German Multicenter Cohort Study on Atopy were included, 38% of whom had an elevated atopic risk. RSV IgG and IgM antibodies were tested by ELISA with gradient purified RSV antigen. Specific IgE against mites, cat dandruff, birch and grass pollens and relevant nutritional antigens were tested with CAP-RAST-FEIA (Pharmacia, Sweden). Of the cord sera 99% were positive for RSV-IgG, 44.7% at one year and 64.2% (n = 265) at two years of age. The positivity rate after 12 months varied with the season of birth, the number of siblings and the degree of exposure to tobacco smoke; and correlated closely with attacks of wheezing during infancy. Twenty (2.8%) children were found to be sensitized against at least one aeroallergen at one year, and 28 (10.5%) at two years. By the first birthday, mite sensitization (n = 3) could only be seen in the RSV-infected children; grass pollen sensitization (n = 9) was associated with RSV seropositivity (logistic regression model including the confounders mentioned above: with RSV IgG < p = 0.048 > and IgM < p = 0.0006 >), as was birch sensitization (n = 5) with RSV IgM (p = 0.009). No such differences could be detected at two years. No correlation of RSV seropositivity to any allergic manifestation could be found. We conclude, that it is only in the first year of life, that RSV infection plays a significant role in promoting sensitization against aeroallergens, which do not at this time produce allergic symptoms.

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Section: Discussionmentioning

confidence: 82%

Respiratory syncytial virus infection: its role in aeroallergen sensitization during the first two years of life

Förster

Tacke

Krebs

et al. 1996

Pediatric Allergy Immunology

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“…Very few studies have examined RSV-specific IgG antibody levels in the context of asthma and/or bronchial hyperreactivity for comparison to our current results. Backer et al examined RSV-specific IgG among a randomly selected group of children between and years of age, but found no association with bronchial hyper-responsiveness to histamine challenge [46]. In another study among 100 children less than 2 years of age hospitalized for wheezing and followed for a median of 6 years, RSV-specific IgG increased with age, but was not associated with asthma at any age [47].…”

Section: Discussionmentioning

confidence: 99%

Respiratory syncytial virus-specific immunoglobulin G (IgG) concentrations associate with environmental and genetic factors: the Factors Influencing Pediatric Asthma Study

Erdei

Torgerson

O'Leary

et al. 2021

Preprint

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Exposure to respiratory syncytial virus (RSV) during childhood is nearly ubiquitous by age two, and infants who develop severe RSV bronchiolitis are more likely to develop asthma later in life. In the Factors Influencing Pediatric Asthma (FIPA) study including 319 children from a Northern Plains American Indian community, we found 73% of children to have high concentrations of RSV-specific IgG (>40 IU/mL). High concentration of RSV-specific IgG was associated with increased exposure to second-hand tobacco smoke (p=7.5x10-4), larger household size (p=4.0x10-3), and lower levels of total serum IgE (p=5.1x10-3). Parents of children with asthma more often reported an RSV diagnosis and/or hospitalization due to RSV, and children with asthma had lower concentrations of RSV IgG as compared to those without asthma among RSV-exposed individuals (mean 117 IU/mL vs. 154, p=7.1x10-4). However, lower RSV IgG was surprisingly exclusive to children with asthma recruited during the winter months when RSV is thought to circulate more broadly. Multivariate regression indicated the strongest predictors of RSV-specific IgG concentration included asthma status (p=0.040), per cent eosinophils (p=0.035), and an asthma x RSV season interaction (p=3.7x10-3). Among candidate genes, we identified a genetic association between an intronic variant in IFNL4 and RSV-specific IgG concentration whereby the minor allele (A) was associated with higher concentration (rs12979860, p=4.3x10-3). Overall our findings suggest there are seasonal differences in immunological response to RSV infection in asthma cases vs. controls, and identify both environmental and genetic contributions that warrant further investigation.

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“…Forster et al found that the RSV‐IgG positivity rate at early childhood correlated closely with attacks of wheezing during infancy, but was not related to the development of any allergic manifestation 14. Backer et al found no relationship between the presence of IgG antibodies against RSV and bronchial hyperreactivity in school‐aged children 15. To our knowledge, the present study is the only one in which RSV infection confirmed by RSV‐specific IgG antibodies has been evaluated with age and with respect to the later occurrence of asthma in children.…”

Section: Discussionmentioning

confidence: 99%

Respiratory syncytial virus infection in children hospitalized for wheezing: Virus‐specific studies from infancy to preschool years

et al. 2005

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Aim: To evaluate whether the presence of immunoglobulin G (IgG) antibodies against respiratory syncytial virus (RSV) in early childhood is associated with later asthma, and to evaluate a new diagnostic test for RSV, reverse‐transcription polymerase chain reaction (RT‐PCR), comparing it to the antigen and antibody assays initially used in RSV diagnostics in the present cohort. Methods: At the start of the study in 1992–1993, RSV was studied by antigen detection (using time‐resolved fluoroimmunoassay) and complement‐fixing antibody assay. Advances in methodology allowed us to supplement RSV studies by RT‐PCR in frozen nasopharyngeal aspirates obtained on admission, and by specific IgG antibodies (using enzyme immunoassay) in frozen serum samples obtained during the follow‐up. Results: On admission, 29 of the 100 children hospitalized for wheezing at <2 y of age were RSV positive. When compared with conventional methods, the sensitivity of RT‐PCR was 83% (100% w.r.t. antigen detection) and its specificity was 92% in diagnosing RSV infection. RSV‐specific IgG antibody concentrations rose with age, but were not predictive of asthma at any age. In the present cohort, wheezing without RSV was particularly associated with increased risk for later childhood asthma. Conclusion: Hospitalization for wheezing in infancy is associated with increased risk for later childhood asthma, particularly in children without RSV infection on admission, although children with RSV have also slightly increased risk for later asthma. However, mere serological evidence of RSV infection is not associated with the development of asthma. In addition to RSV, more attention should be paid to less virulent agents in order to find those wheezing infants who are at particular risk of later childhood asthma.

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Relationship between viral antibodies and bronchial hyperresponsiveness in 495 unselected children and adolescents

Cited by 6 publications

References 30 publications

Respiratory syncytial virus infection: its role in aeroallergen sensitization during the first two years of life

Respiratory syncytial virus infection: its role in aeroallergen sensitization during the first two years of life

Respiratory syncytial virus-specific immunoglobulin G (IgG) concentrations associate with environmental and genetic factors: the Factors Influencing Pediatric Asthma Study

Respiratory syncytial virus infection in children hospitalized for wheezing: Virus‐specific studies from infancy to preschool years

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