Relationship between visual field progression and baseline refraction in primary open-angle glaucoma

Naito, Takeo; Yoshikawa, Keiji; Mizoue, Shiro; Nanno, Mami; Kimura, Tohru; Suzumura, Hirotaka; Umeda, Yuzo; Shiraga, Fumio

doi:10.2147/opth.s109732

Cited by 11 publications

(16 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Literature shows nonsignificant effect of myopia on NTG,[ 16 , 26 , 27 , 29 , 32 , 34 ] and even protective role in some studies. [ 15 , 16 , 34 , 35 ] Caution is needed in a perspective that the progressive course of myopic NTG might differ from nonmyopic NTG. It has been suggested that RNFL defects in myopia might not progress further.…”

Section: Discussionmentioning

confidence: 99%

“…In NTG, we could observe both positive and negative results on the relationship between glaucoma progression and IOP, CCT, and myopic degrees. [ 10 , 25 – 35 ] The role of increased IOP in glaucomatous damage seems concrete, even in NTG, although it may not be the only factor. These inconsistent results would thus imply that non-IOP factors would affect glaucoma progression, especially in NTG patients.…”

Section: Introductionmentioning

confidence: 99%

“…[ 15 ] In studies with NTG patients in Japanese population, myopia was a positive factor for glaucoma progression. [ 27 , 34 , 35 ] Meanwhile, there are other studies reporting absence of difference in glaucoma progression between myopic and nonmyopic group. [ 16 , 27 , 32 , 38 ]…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Intereye comparison of ocular factors in normal tension glaucoma with asymmetric visual field loss in Korean population

2017

View full text Add to dashboard Cite

PurposeTo identify ocular parameters corresponding to asymmetric visual field (VF) loss in normal tension glaucoma (NTG) through intereye comparisons. Patients and methodsMedical records of NTG patients with asymmetric and symmetric VF losses were retrospectively reviewed. The criterion for asymmetry in VF was 6 dB difference of mean deviation. Refractive error, intraocular pressure (IOP), central corneal thickness, ovality index, and peripapillary atrophy (PPA)/disc area ratio were obtained from each patient. Intereye comparison was performed for asymmetric group, symmetric group, and myopic and nonmyopic asymmetric subgroups. ResultsWe included 155 patients; 110 patients in asymmetric group and 45 patients in symmetric group. In intereye comparison for total asymmetric group, refractive error (P = 0.006), initial IOP (P = 0.001), ovality index (P = 0.008), and PPA (P < 0.001) were significantly asymmetric. For myopic subgroup, refractive error (P = 0.004), ovality index (P = 0.001), and PPA (P = 0.003) were significant factors. For nonmyopic subgroup, initial IOP (P = 0.003) and PPA (P = 0.007) were significant factors. Symmetric group showed no significant difference between the eyes. Multivariate analysis demonstrated that refractive error (P = 0.002) and PPA (P = 0.028) were significant factors in myopic subgroup, and initial IOP (P = 0.022) and PPA (P = 0.002) were significant factors in nonmyopic subgroup. ConclusionsIn this intereye comparison, the more myopic eye in myopic NTG patient, and the more pressured eye in nonmyopic NTG patient demonstrated more severe VF loss. Myopic and nonmyopic patients may follow different pathophysiologic processes. Discriminative attentions should be paid to NTG patients by subtypes.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Intereye comparison of ocular factors in normal tension glaucoma with asymmetric visual field loss in Korean population

2017

View full text Add to dashboard Cite

show abstract

“…Thus, some myopic eyes with VF defects tend to be misdiagnosed as glaucoma, and this might have led to the conclusion of the significantly faster MD slope of the non-myopic group than that of the highly myopic group. 30 …”

Section: Discussionmentioning

confidence: 99%

Is high myopia a risk factor for visual field progression or disk hemorrhage in primary open-angle glaucoma?

Nitta¹,

Sugiyama²,

Wajima³

et al. 2017

OPTH

View full text Add to dashboard Cite

PurposeThe purpose of this study was to clarify differences between highly myopic and non-myopic primary open-angle glaucoma (POAG) patients, including normal-tension glaucoma patients.Patients and methodsA total of 269 POAG patients were divided into two groups: patients with ≥26.5 mm of axial length (highly myopic group) and patients with <24.0 mm of axial length (non-myopic group).ResultsWe analyzed 53 highly myopic and 93 non-myopic POAG patients. Age at first visit of the highly myopic group was significantly less than that of the non-myopic group (P<0.0001). Baseline intraocular pressures (IOPs) showed no significant differences. Follow-up IOPs of the non-myopic group were significantly lower than those of the highly myopic group (P=0.0009). According to the mean deviation definition of progression, the cumulative probability of non-progression of visual field (VF) loss was significantly greater in the highly myopic group (10-year survival rate, 73.7%±6.8%) than in the non-myopic group (10-year survival rate, 46.3%±5.8%; log-rank test, P=0.0142). The occurrence of disk hemorrhage (DH) in the non-myopic group (1.60±3.04) was significantly greater than that in the highly myopic group (0.93±2.13, P=0.0311). The cumulative probability of DH was significantly lower in the highly myopic group (10-year survival rate, 26.4%±5.4%) than in the non-myopic group (10-year survival rate, 47.2%±6.6%, P=0.0413).ConclusionHighly myopic POAG is considered as a combination of myopic optic neuropathy and glaucomatous optic neuropathy (GON). If GON is predominant, it has frequent DH and more progressive VF loss. However, when the myopic optic neuropathy is predominant, it has less DH and less progressive VF loss.

show abstract

“…In addition to IOP, some other ocular parameters do play a role in glaucomatous optic nerve damage. Myopic optic disc changes could affect the pathogenesis of glaucoma, whereas the exact effect remains unclear [11][12][13]. A recent evidence-based review provided a more accurate illustration that myopia might be involved in the development of glaucoma, but not for its progression [14].…”

Section: Introductionmentioning

confidence: 99%

Intereye Comparison of Focal Lamina Cribrosa Defect in Normal-Tension Glaucoma Patients with Asymmetric Visual Field Loss

et al. 2020

View full text Add to dashboard Cite

Introduction: To evaluate the association of focal lamina cribrosa (LC) defect with asymmetric visual field (VF) loss in normal tension glaucoma (NTG) through inter-eye comparisons. Methods: Paired eyes were divided into better and worse eyes according to the mean deviation (MD), and ocular parameters were compared between them. Furthermore, patients in asymmetric group were classified as subgroup A (one eye with LC defect and the fellow one without), subgroup B (both eyes without LC defect) and subgroup C (both eyes with LC defect). Generalized estimation equation approach was used to evaluate the association between ocular parameters and asymmetric VF. Results: A total of 140 eyes of 70 NTG patients were included in asymmetric group. LC defects were more common in better eyes than that in worse eyes (27/70 [38.57%] vs 10/70 [14.29%], P=0.001), and all eyes with LC defect had myopia. Multivariate analysis revealed that the presence of LC defect was significantly associated with better eyes in asymmetric group (odds ratio, 0.27; P=0.001). For subgroup A, eyes with LC defects exhibited lower peak IOP (P=0.011) and lower mean IOP (P=0.018) than the fellow eyes without. In addition, longer AL (P=0.025) and larger tilt ratio (P=0.032) was found in eyes with LC defects. For subgroup B without LC defects, larger tilt ratio was shown to be a risk factor for VF loss (odds ratio, 6.13; P=0.001). There was no significant difference of binocular parameters except for MD (P<0.001) in subgroup C. Conclusions: LC defects in myopia were suggested to be associated with better eyes in NTG with asymmetric VF loss. However, in patients without LC defect, larger tilt ratio was a risk factor for VF defect. There might be different pathological mechanisms in asymmetric VF loss for different NTG subtypes.

show abstract

Relationship between visual field progression and baseline refraction in primary open-angle glaucoma

Cited by 11 publications

References 41 publications

Intereye comparison of ocular factors in normal tension glaucoma with asymmetric visual field loss in Korean population

Intereye comparison of ocular factors in normal tension glaucoma with asymmetric visual field loss in Korean population

Is high myopia a risk factor for visual field progression or disk hemorrhage in primary open-angle glaucoma?

Intereye Comparison of Focal Lamina Cribrosa Defect in Normal-Tension Glaucoma Patients with Asymmetric Visual Field Loss

Contact Info

Product

Resources

About