2012
DOI: 10.4254/wjh.v4.i8.242
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Relationship between vitamin D and IL-23, IL-17 and macrophage chemoattractant protein-1 as markers of fibrosis in hepatitis C virus Egyptians

Abstract: AIM:To assess vitamin D in hepatitis C patients and its relationship to interleukin (IL)-23, IL-17, and macrophage chemoattractant protein-1 (MCP-1). METHODS:The study was conducted on 50 Egyptian hepatitis C virus (HCV) genotype number IV-infected patients and 25 age-and gender-matched healthy subjects. Venous blood samples were obtained. Samples were allowed to clot and sera were separated by centrifugation and stored at -20 ℃. A 25 hydroxy vitamin D assay was carried out using solid phase RIA. A 1,25 dihydr… Show more

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Cited by 31 publications
(24 citation statements)
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“…The values were significantly higher in cirrhotic states and correlated well with the severity of the cirrhosis (Jimenez-Sousa et al, 2010). In other studies, the comparison was made between HCC and cirrhotic patients; here, the levels in the HCC patients were significantly higher than those in cirrhotic counterparts (El Husseiny et al, 2012;Wang et al, 2010Wang et al, , 2011Zhang et al, 2009). The ROC analyses performed in the current study showed that there was a high sensitivity and specificity for the predictive validity of IL-17 in differentiating between cirrhotic vs HCC states (100% sensitivity and 86% specificity).…”
Section: Discussionsupporting
confidence: 45%
“…The values were significantly higher in cirrhotic states and correlated well with the severity of the cirrhosis (Jimenez-Sousa et al, 2010). In other studies, the comparison was made between HCC and cirrhotic patients; here, the levels in the HCC patients were significantly higher than those in cirrhotic counterparts (El Husseiny et al, 2012;Wang et al, 2010Wang et al, , 2011Zhang et al, 2009). The ROC analyses performed in the current study showed that there was a high sensitivity and specificity for the predictive validity of IL-17 in differentiating between cirrhotic vs HCC states (100% sensitivity and 86% specificity).…”
Section: Discussionsupporting
confidence: 45%
“…17 While the majority of studies have assessed IL-23 in the context of autoimmune disease, other studies in chronic viral infections such as HCV and HIV have also suggested a role for IL-23. Elevated plasma IL-23 levels have been associated with chronic hepatitis C virus genotype 4 infection, 18 and monocytes from chronic HCV patients have exaggerated IL-23 production in vitro. 19 However, these studies do not assess response to therapy, and no data exist on IL-23 levels with HCV therapy, or the potential role of IL-23 as a mechanism of viral clearance.…”
Section: Discussionmentioning
confidence: 99%
“…Interestingly, a significant progressive decline in active vitamin D levels is associated with progressive exacerbation of the hepatic disease states. The above results indicate that a decrease in vitamin D levels could reflect the severity of hepatocellular injury and so serve as a new hepatic biomarker in progressive liver diseases [8,9].…”
Section: Introductionmentioning
confidence: 77%