Relationship between white blood cells and hypertension in Chinese adults: The Cardiometabolic Risk in Chinese (CRC) study

Sun, Yuting; Gong, Ying; Zhu, Ruihua; Liu, Xuekui; Zhu, Yan; Wang, Yu; Qiu, Qinqin; Qi, Lu; Liang, Jun

doi:10.3109/10641963.2015.1036058

Cited by 14 publications

(12 citation statements)

References 30 publications

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“…In recent years, white blood cells (WBCs) have been considered as an inflammatory factor (Chung et al, 2016). The elevated WBCs count has widely recognized in association with several diseases such as metabolic syndrome (Yang et al, 2017), cardiovascular disease (Lassale et al, 2018), diabetes (Gu et al, 2018), hypertension (Sun et al, 2015), non-alcoholic fatty liver (Chung et al, 2016), polycystic ovary syndrome (Papalou et al, 2015), infections and chronic inflammation (Dixon and O'Brien, 2006) and even mortality (Kabat et al, 2017). Today, the predictive value of WBCs for the diseases is considered similar to total cholesterol (Panagiotakos et al, 2005;Kabat et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Associations between white blood cells count and obesity in apparently healthy young adults

Ghannadiasl

2020

NFS

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Purpose The elevated white blood cells (WBCs) count has been reported to be a predictor of cardiovascular diseases, diabetes, hypertension and metabolic syndrome. This study aims to determine the associations between WBCs count and obesity in apparently healthy young adults. Design/methodology/approach In this cross-sectional study, the authors evaluated the body mass index (BMI) in 392 apparently healthy young adults of both sexes. The WBCs count was measured using standard counter techniques. The inclusion criteria were the agreement to participate in the study, between 18 and 25 years of age, lack of self-reported diseases such as cardiovascular diseases, hypertension, kidney and infectious diseases. Findings According to the BMI classification, underweight and overweight or obesity were observed in 14.58 and 11.48 per cent of young adults, respectively. The mean WBC was 6.5 ± 1.5 (×10³ cells/µL). Higher values of WBCs were found in women than in men (p = 0.02). The young adults with higher BMI had a higher WBCs count. There was a positive correlation between WBCs count and weight and BMI (r = 0.19 and r = 0.22, p < 0.001, respectively). Research limitations/implications This research was a cross-sectional study. Future studies are suggested using longitudinal studies to examine more relationships between obesity and WBCs count in apparently healthy young adults. Practical implications The results of this study provide evidence for weight management in this age group to reduce diseases associated with increased WBCs count. Originality/value The WBCs count was related to increasing levels of BMI per cent 2 C even in the normal range.

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Section: Introductionmentioning

confidence: 99%

Associations between white blood cells count and obesity in apparently healthy young adults

Ghannadiasl

2020

NFS

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“…Increasing quantity of sodium serves as an anticoagulant and bursting agent for WBCs as shown in Figure 3(c, d, e, f). WBCs count is elevated in hypertension (WHITWORTH, 2004, NAKANISHI et al, 2002, SUN et al, 2015.…”

Section: Discussionmentioning

confidence: 99%

“…Hypertension alters erythrocytes structure, reduces oxygen transport, increases blood viscosity and rouleaux formation (CICCO; PIRRELLI, 1999). Hypertension increases RBCs count and reduces MCV (SUN et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Rouleaux formation of white blood cells and platelets in leukemia

Ullah¹,

Naeem²,

Akhtar³

et al. 2018

Biosci. J.

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ABSTRACT:The objective of this study was to measure the effects of glucose and salt level on white blood cells, red blood cells and platelets (PLTs) in the blood of a leukemic patient by using a white light microscope. Different concentrations of glucose and salt in the range of 0 mM to 500 mM were admixed in the blood sample to prepare blood smear. We revealed that shape of erythrocytes, leukocytes and platelets changes and form aggregates. Increasing concentrations of glucose cause to increases aggregation process of white blood cells, red blood cells and platelets. And the increasing concentration of sodium chloride causes to increase rouleaux formation and aggregation of platelets but dehydration due to increased sodium chloride concentration causes to break the aggregation of white blood cells.Comparison of CBC reports of these samples with and without analytes shows that total leukocyte count (TLC) decreases gradually towards normal ranges of leukocytes which is favorable in the treatment of leukemia but at the same time decreasing level of hemoglobin HGB, mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC) and increasing level of red blood cell (RBCs) causes to reduce oxygen supply which is in favor of cancer growth and anemia. This work provides us the base for translation this in vitro study towards the in vivo case of blood microvasculature as a non-invasive methodology.

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“…Leukocyte level count reflected low-grade systemic inflammation. Leukocyte count could independently predict hypertension in Chinese adults 16 . Two studies shown that hyperuricemia correlated with leukocyte count 17,18 .…”

Section: Introductionmentioning

confidence: 99%

The relationship between leukocyte level and hypertension in elderly patients with hyperuricemia.

Shen

Zhao²,

et al. 2020

Preprint

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Background : This study was to evaluate the change of leukocyte level caused by hyperuricemia and explore the relationship between leukocyte level and hypertension in elderly patients with hyperuricemia. Methods: A cross-sectional study of serum uric acid level was conducted in 1352 elderly people over 65 years old . The study samples were divided into three categories according to the tertiles of leukocyte: Tertile 1, leukocyte≤5.2 × 10 9 /L; Tertile 2, leukocyte=5.3~6.3 × 10 9 /L; and Tertile 3, leukocyte≥6.4 × 10 9 /L. Multiple logistic regression models were used for modeling relationships between leukocyte, hyperuricemia and hypertension. In vitro, human vascular endothelial cells (HUVECs) were treated by different concentrations of UA (0, 4, 8, 16 mg/dl) for 24 h, then cells were collected. Some cytokines were measured. Reactive oxygen species (ROS) were analyzed with a fluorescence microscope. Results: The levels of leukocyte were higher in elderly patients with hyperuricemia than without hyperuricemia( P <0.01). In multiple logistic regression, hyperuricemia was an independent risk factor of leukocyte in Tertile 3 (OR=1.657, 95%CI: 1.180～2.328, P =0.004). The prevalences of hypertension were higher in elderly patients with hyperuricemia than without hyperuricemia (77.0% vs 63.5%, χ 2 =11.447, P =0.001). In multiple logistic regression (Model 1), hyperuricemia was an independent risk factor of hypertension (OR=1.536, 95%CI: 1.026～2.302, P =0.037). Leukocyte in Tertile 3 was an independent risk factor of hypertension in Model 2 (OR= 1.333, 95%CI: 1.031~1.724, P =0.028). Expression levels of IL-1β, iNOS and TNF-α were obviously higher in the 8mg/dl UA group and 16mg/dl UA group than that in the control group ( P <0.05). Expression level of eNOS was obviously lower in the 8mg/dl UA group and 16mg/dl UA group than that in the control group ( P <0.05). The production of ROS in the 8mg/dl UA group and in the 16mg/dl UA group were obviously higher than that in the control group ( P <0.05). Conclusion: The present study demonstrated that hyperuricemia was associated with an increased risk for hypertension. The chronic inflammation caused by hyperuricemia maybe one of important pathogenesis of incident hypertension in patients with hyperuricemia.

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Relationship between white blood cells and hypertension in Chinese adults: The Cardiometabolic Risk in Chinese (CRC) study

Cited by 14 publications

References 30 publications

Associations between white blood cells count and obesity in apparently healthy young adults

Associations between white blood cells count and obesity in apparently healthy young adults

Rouleaux formation of white blood cells and platelets in leukemia

The relationship between leukocyte level and hypertension in elderly patients with hyperuricemia.

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