Relationship of Age, Body Mass Index, Bone Density, and Menopause Duration with Alveolar Bone Resorption in Postmenopausal Women

Puspitadewi, Susi R.; Wulandari, Pitu; Kusdhany, Lindawati S.; Masulili, Sri Lelyati C.; Iskandar, Hanna Bachtiar; Auerkari, Elza Ibrahim

doi:10.4034/pboci.2019.191.92

Cited by 6 publications

(7 citation statements)

References 25 publications

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“…Osteoporosis is common in menopausal patients and seems to have an effect on alveolar bone thickness (Puspitadewi et al, 2019 ). To eliminate the effect of the confounding agent, we excluded osteoporotic patients by the following method.…”

Section: Methodsmentioning

confidence: 99%

“…Estrogen deficiency facilitates the absorption and maturation of osteoclasts and initiates the process of bone resorption due to cytokines, such as interleukin, IL‐α, interleukin6, interleukin11, and TNF‐α (Zhao, 2012 ) Although the effect of menopause on the skeletal system of the body has been determined, there is still controversy about the alveolar bone. Some studies report a decrease in alveolar bone volume in menopausal women (Puspitadewi et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

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CBCT evaluation of buccal bone thickness in the aesthetic zone of menopausal women: A cross‐sectional study

Naghibi

Fatemi

Hoseini-Zarch

et al. 2022

Clinical & Exp Dental Res

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Objectives: Dental implants are a known treatment today. It is necessary to have at least 2 mm of bone around the implant, especially in the buccal aspect of the anterior maxilla (esthetic zone). Some systemic conditions, such as menopause, can affect the body's bone mass as well as the alveolar bone. Considering that few studies have been carried out on the effect of menopause on the thickness and topography of alveolar bone, we decided to investigate the effect of menopause on buccal alveolar bone thickness in the anterior maxillary teeth in menopausal women.Material and Methods: In this descriptive-analytical cross-sectional study, two subgroups of menopausal women and nonmenopausal women were considered. Data were extracted from 30 patients referred to a private radiology center in Mashhad for CBCT imaging. In addition, the buccal bone thickness in the crest and middle areas of the anterior maxillary teeth was measured and the difference between the two groups was investigated. The buccal bone thickness of the aesthetic area was evaluated with CBCT Planmeca ProMax 3D Max (Planmeca) by Planmeca Romexis 5.3.4 software, with 200 μm Voxel size and Fov 90 × 60 mm.Results: In this study, 30 women with a mean age of 49.75 ± 3.65 years in the nonmenopausal and menopausal groups were examined. It was found that the mean buccal bone thickness of the anterior maxilla in the nonmenopausal group (0.65 ± 0.25 mm) was higher than in the menopausal group (0.56 ± 0.20 mm), but the difference was not statistically significant (p = .2999). Only in the crestal bone of the right canine, the average bone thickness in nonmenopausal group (0.77 ± 0.33 mm) was significantly higher than the menopausal group (0.49 ± 0.22 mm) (p = .011).

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

CBCT evaluation of buccal bone thickness in the aesthetic zone of menopausal women: A cross‐sectional study

Naghibi

Fatemi

Hoseini-Zarch

et al. 2022

Clinical & Exp Dental Res

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“…Prolonged duration of menopause, diminishes the action of estradiol and its role is soon taken over by estrone. Estrogen, produced by adipose tissue, correlates better with fat tissues present in woman (11). Another theory proposes that obesity releases hormones like preptin and amylin from the beta cells of the pancreas along with insulin that stimulates bone formation (12).…”

Section: Discussionmentioning

confidence: 99%

Influence of duration of menopause on bone turnover markers in post-menopausal women

Rai¹,

Rai²,

Dsa³

et al. 2022

Biomedicine

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Introduction and Aim: Osteoporosis is common among women following 10 years of cessation of menstruation, due to bone loss accelerated by menopause. The study was done to evaluate the effect of duration of menopause on bone turnover markers (BTMs). Materials and Methods: The study involved 100 postmenopausal women; 50 osteoporotic and 50 non-osteoporotic. Comparison and correlation of serum calcium, phosphorus, alkaline phosphatase (ALP), serum osteocalcin (sOC) and urinary hydroxyproline (uHP) were done based on duration of menopause. Comparison of biochemical parameters was done using Independent t-test and ANOVA test for two groups and more than two groups respectively. Correlation was done using Pearson’s correlation test. Statistical significance was considered at p<0.05. Results: The sOC significantly declined and uHP levels increased between quartiles of duration of menopause among study participants. (p<0.001). However, in those without fractures, sOC and uHP were higher in those with <7 years since menopause (YSM) and then plateaued after 8 YSM. The percentage of osteoporotic women having >15 YSM was 82%. Duration of menopause correlated better with sOC (r=-0.633) than uHP (r=0.575) (p<0.001). Conclusion: Osteoporotic fractures were higher in more than 15 YSM. There was no difference in both sOC and uHP in those with fractures, proving non-significance of screening these markers once the fractures have occurred. As sOC correlates better with duration of menopause, monitoring of sOC in early years of menopause is required to prevent osteoporotic fractures and associated burden through prophylactic treatment.

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“…The prolonged duration of menopause depletes the action of Estradiol and its task is replaced by estrone. Estrogen produced by adipose tissue correlates well with the fat tissues present in a woman (13). Another theory proposes that obesity releases hormones like preptin and amylin from the beta cells of the pancreas along with insulin that stimulates bone formation (14).…”

Section: Discussionmentioning

confidence: 99%

The Impact of Duration of Menopause on Bone Metabolism in Detecting and Preventing Osteoporotic Fractures

Rai

Hegde²,

Rai

et al. 2021

Preprint

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Background: Menopause accelerates bone loss after 10 years of cessation of the menstrual cycle causing osteoporosis. Hip fractures among postmenopausal women escalate morbidity and mortality in these women. Objective: The study was done to evaluate the effect of duration of menopause on BTMs so that it could detect post-menopausal osteoporosis at the earliest and predict the fracture risk Materials and Methods: The study was conducted in a tertiary hospital in Mangalore on 100 postmenopausal women. The duration of menopause was divided into quartiles. Evaluation and correlation of serum osteocalcin, urinary hydroxyproline, BMI, calcium, phosphorous and alkaline phosphatase was done on the duration of menopause. The subjects comprised 50 osteoporotic and 50 non-osteoporotic post-menopausal women. Continuous variables were represented as median and interquartile ranges. Comparison between two groups was done using the Mann Whitney U test. Comparison between more than two groups was done using the Kruskal Wallis test. The correlation was done using spearman’s correlation test. Statistical significance was considered at p<0.05. Results: Serum osteocalcin levels significantly declined and urinary hydroxyproline levels elevated between quartiles of duration of menopause in the entire study group and in osteoporotic women. (p<0.001). There was no significant difference in osteocalcin and hydroxyproline levels between the quartiles in the fracture group. 82% of the osteoporotic had >15 YSM. Conclusion: Osteocalcin levels plateaued after 8years of menopause and started decreasing after 15 YSM. Osteoporotic fractures were higher in more than 15 YSM and the osteocalcin level was 2.47 ng/ml in this quartile. There is no significant difference in osteocalcin levels in those with fractures, indicating no significance of screening for serum osteocalcin levels once the fractures have occurred. Hence concluding that the duration of menopause is the key indicator for osteoporosis and serum osteocalcin is a potent biomarker for detection of the risk of fracture. Monitoring of serum osteocalcin levels(<2.55ng/ml) after 8 years of menopause is very essential for early prophylactic treatment in order to prevent osteoporotic fractures and the burden associated with it. KEYWORDS: Duration of menopause, osteocalcin, quartiles, urinary hydroxyproline, osteoporotic fractures

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Relationship of Age, Body Mass Index, Bone Density, and Menopause Duration with Alveolar Bone Resorption in Postmenopausal Women

Cited by 6 publications

References 25 publications

CBCT evaluation of buccal bone thickness in the aesthetic zone of menopausal women: A cross‐sectional study

CBCT evaluation of buccal bone thickness in the aesthetic zone of menopausal women: A cross‐sectional study

Influence of duration of menopause on bone turnover markers in post-menopausal women

The Impact of Duration of Menopause on Bone Metabolism in Detecting and Preventing Osteoporotic Fractures

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