Relationship of Benign and Malignant Hyper-Nephroid Tumors of Kidney: Clinical and Pathological Study of 77 Cases in 12, 885 Necropsies

Kozoll, Donald D.; Kirshbaum, Jack D.

doi:10.1016/s0022-5347(17)71290-6

Cited by 46 publications

(6 citation statements)

References 5 publications

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“…Although such a definition remains somewhat arbitrary and controversial, changes in criteria over the years have been predominantly in size. In early autopsy series, renal papillary adenomas were defined as tumors measuring less than 3 cm in diameter and were reported to have an incidence ranging from 0.26% [17,18] to 22.4% [19]. In the 1986 Mainz classification system of renal tumors [20], adenomas were defined as measuring less than 1 cm in diameter, having grade 1 nuclear morphology and were further subclassified into 4 categories: chromophilic (basophilic), eosinophilic, clear cell, and chromophobe.…”

Section: Discussionmentioning

confidence: 99%

Renal papillary adenoma—a putative precursor of papillary renal cell carcinoma

et al. 2007

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Section: Discussionmentioning

confidence: 99%

Renal papillary adenoma—a putative precursor of papillary renal cell carcinoma

et al. 2007

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“…Renal adenoma is a relatively rare condition, and the occurr‐ence in autopsy studies has been reported as 0.26%, 2 7–11%, 3 and 22.4% 4 . Recently, its frequency has increased due to the development of imaging technology 7 .…”

Section: Discussionmentioning

confidence: 99%

“…Adenoma is occasionally encountered at surgery or autopsy. In various series of autopsy cases, 0.26–22.4% cases showed renal adenoma 2–4 . However, the occurrence of bilateral multiple small adenomas is quite rare.…”

mentioning

confidence: 99%

Multicentric papillary renal cell carcinoma associated with renal adenomatosis

Kiyoshima¹,

Oda²,

Nakamura³

et al. 2004

Pathology International

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A case of multicentric papillary renal cell carcinoma (RCC) associated with renal adenomatosis in the bilateral kidneys is reported. Bilateral multiple renal cysts in a 46-year-old man were pointed out incidentally by ultrasonography. Some of the left renal lesions were considered to be RCC, and left radical nephrectomy was performed accordingly. The left kidney was occupied by numerous solid nodules, which ranged from yellow to tan in color, and some of the large ones had foci of hemorrhage and necrosis. Microscopically, most of the tumors showed papillary RCC associated with renal adenoma, while others consisted only of adenomas. Ten months later, multiple lesions of the right kidney, which were initially considered to be multiple cysts, were found to have become enlarged and some of them were diagnosed as RCC. Thus, right radical nephrectomy was also performed, and these tumors showed the same features as the left renal tumors. The patient's familial history was not remarkable. The kidneys revealed various histological features, ranging from dysplastic to adenoma or carcinoma, including transitional or overlapping features between them. The findings suggest an adenoma-carcinoma sequence in papillary RCC. It is worth considering such entities.

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“…These criteria have all been called into question at one time or another in the literature. Some consider all adenomas, regardless of size or differentiation, to be premalignant lesions (Kozoll and Kirshbaum, 1940). Others consider them to be already malignant (Cabot and Middleton, 1938).…”

Section: Discussionmentioning

confidence: 99%