Relationship of Colorectal Polyps and the Risk Factors Including Obesity, Age, Alcohol and Smoking

Abstract

Controversy remains over the role of risk factors in developing colorectal polyps. The aim of this study was to investigate the relationship of colorectal polyps with risk factors including obesity, age, alcohol, and smoking. We retrospectively assessed colorectal polyps through medical records and patient interviews of 1080 patients who underwent colonoscopy regardless of symptoms. The degree of obesity was determined by body mass index (BMI), and colorectal polyps were divided into hyperplastic and adenomatous polyps. The prevalence of colorectal polyps was 45.3% (489 patients). Of these, the prevalences of hyperplastic polyps and adenomatous polyps were 23.3% and 26.7%, respectively. The most common number, size, and location of colorectal polyps were one (63.8%), 5.0∼9.0 mm (50.1%), and rectosigmoid colon (35.7%), respectively. Age, amount of alcohol, and smoking were significantly higher in the group with polyps than in that without polyps (54.9±11.3 vs. 50.0±13.1 years, 75.8 vs. 39.3 g/week, and 9.3±12.6 vs. 4.6±9.1 pack years, respectively, p=0.001). There were no significant differences in BMI between the groups with (23.2 kg/m 2 ) or without (23.1 kg/m 2 ) polyps. Also, there was no significant relationship between BMI and the size, number, or location of colorectal polyps. Age, alcohol, and smoking were associated with colorectal polyps by one-way ANOVA test but not by multivariate logistic regression analysis. Additionally, BMI had no relationship with the size, number, or location of colorectal polyps. In conclusion, age, alcohol drinking, and smoking may be associated with colorectal polyps, but obesity as assessed by BMI was not.

Risk Factors of Colon Polyps in Colonoscopy Examinee

“…연구도구는 선행연구 결과 및 문헌고찰 (Ji et al, 2007;Kim et al, 2002;Lee et al, 2007;Nam & Yang, 2008) 족력( p = .293), 복부불편감 유무( p = .463), 변의 무시 경험( p = .147), 1년 이내 건강검진 유무(p = .857), 소화기질환 과거력(p = .647), 소화기질환 현재력(p = .272), 수술경험(p = .077), BMI (p = .858), 총콜 레스테롤(p = .657)은 대장용종의 발병에 유의한 차이가 없었다. (Choe & Lee, 2011;Kim et al, 2002;Kim, Kim, & Jeong, 2005;Lee et al, 2009;Park, 2008;Song, 2009). 본 연 (Kim et al, 2005;Park, Jang, & Min, 2002 (Park, 2008;Song, 2009), 혈당 (Ji et al, 2007)…”

“…현재까지 대장용종 발생의 위험요인으로 음주, 흡연, 비만, 고혈 당, 고중성지방혈증, 운동부족이 알려져 있으나, 이들 위험인자에 대한 국내 여러 연구들 (Ji et al, 2007;Kim et al, 2002;Lee et al, 2009;Nam & Yang, 2008;Park, 2008) (Jeon, 2000;Lee et al, 2007 (Erhardt, Kreichgauer, Meisner, Bode, & Bode, 2002;Lieberman, Prindiville, Weiss, & Willett, 2003). 국내에서 도 고지방식이 및 식이섬유질의 섭취는 대장용종의 발생과 유의한 관계가 없었던 보고 (Jeon, 2000)가 있는가 하면, 식물성 식이섬유섭 취가 대장용종의 감소와 관련이 있고 (Nam & Yang, 2008)…”

“…대장용종의 위험요인 카이제곱 검정 후 통계적으로 유의한 변수들만으로 다중 로지스 틱회귀분석을 실시하였고 그 결과는 Table 4와 같다. 먼저 일반적 특성에서는 성별이 대장용종 발병에 유의한 차이가 있었는데 이는 성별이 남성일 때 대장용종이 유의하게 증가된다는 보고(Kim et al, 2002;Lee et al, 2009;Nam & Yang, 2008)와 일치하였 다. 하지만 다중로지스틱 회귀분석을 하였을 때는 성별은 대장용종 발생의 유의한 위험인자가 아니었다.…”

The Association between Serum Vitamin D Concentration and Colon Polyp: A Cross-Sectional Study Using Health Care Screening Database in a Tertiary Hospital in Korea

“…11) There is an increasing interest in analyzing environmental risk factors that can affect this transformation. 12) Early detection and removal of colon polyps is an important preventive method of colon cancer, but primary prevention to prevent the occurrence of colon polyps may be achieved by managing risk factors.…”

“…Recently, the mechanism of colorectal cancer is thought to progress as an “adenoma to carcinoma transformation”, which means conversion from colorectal adenomas to colorectal cancer [ 11 ]. There is an increasing interest in analyzing environmental risk factors that can affect this transformation [ 12 ]. Early detection and removal of colon polyps is an important preventive method of colon cancer, but primary prevention to prevent the occurrence of colon polyps may be achieved by managing risk factors.…”