Relationship of D-Dimer and Prediction of Pulmonary Embolism in Hospitalized COVID-19 Patients: A Multicenter Study

Nadeem, Iftikhar; Anwar, Adeel; Jordon, Louise; Mahdi, Noor; Rasool, Masood Ur; Dakin, Jonathan; Lok, She

doi:10.2217/fmb-2021-0082

Cited by 10 publications

(9 citation statements)

References 30 publications

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“…Studies are conflicting about the usefulness of Wells PE scores and D-dimers in predicting PE in COVID-19 [26][27][28]. Our study supports the combined approach of using Wells PE score and D-dimer in COVID-19 patients.…”

Section: Diagnostic Challenges In Covid-19-associated Pesupporting

confidence: 76%

“…This approach enables clinicians to screen patients effectively and avoid unnecessary testing, as shown by previous studies [22][23][24][25]. The utility of this algorithm has not been robustly tested in the COVID-19 setting [26][27][28]. Therefore, we designed this study to validate the combined approach of using D-dimers and Wells scores to diagnose VTE in COVID-19 patients.…”

Section: Introductionmentioning

confidence: 99%

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Combined Use of Wells Scores and D-dimer Levels for the Diagnosis of Deep Vein Thrombosis and Pulmonary Embolism in COVID-19: A Retrospective Cohort Study

Raj¹,

Chandna²,

Doukas³

et al. 2021

Cureus

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IntroductionDeep vein thrombosis (DVT) and pulmonary embolism (PE) are key complications of coronavirus disease 2019 . The study's primary outcome was assessing the utility of Wells DVT, Wells PE scores, and D-dimers in diagnosing DVT and PE. Secondary outcomes were the risk factors for the development of PE and DVT in COVID-19 patients. Materials and methodsWe compared COVID-19 patients with a positive and negative lower extremity (LE) duplex. A similar approach was made for patients who underwent imaging for PE. ConclusionsThe combined approach of using a Wells DVT score of 3 in suspected DVT and Wells PE score of 4 in suspected PE and D-dimers of 500 ng/ml may be used to diagnose PE and DVT in COVID-19. Venous thromboembolism (VTE) occurrence in COVID-19 is associated with non-traditional risk factors such as intubation and higher severity of systemic inflammation, and these patients may benefit from more aggressive testing for VTE.

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Section: Diagnostic Challenges In Covid-19-associated Pesupporting

confidence: 76%

Section: Introductionmentioning

confidence: 99%

Combined Use of Wells Scores and D-dimer Levels for the Diagnosis of Deep Vein Thrombosis and Pulmonary Embolism in COVID-19: A Retrospective Cohort Study

Raj¹,

Chandna²,

Doukas³

et al. 2021

Cureus

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“…Thus, due to the cytokine storm caused by the acute infection of COVID-19, together with hypoxia secondary to lung injury and diffuse intravascular coagulation, it causes venous thromboembolism due to coagulopathy (Rostami and Mansouritorghabeh, 2020). Interestingly, in our study, mild elevation of D-dimer in the first hospital day (cutoff point 1.1 mg/L), even with no direct association with thromboembolic phenomenon, had a good accuracy for prediction of death during the days of hospitalization (Nadeem et al, 2021). Recent studies directly have described high levels of D-dimer during hospitalization as a predictor of mortality, especially in patients with DM and the elderly (Soni et al, 2020;Mouhat et al, 2020).…”

Section: Discussionmentioning

confidence: 51%

The role of biomarkers in the prediction of mortality in hospitalized patients for COVID-19

et al. 2022

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Background: Despite the advances in the prognostic determinants in patients with COVID-19, it is not well known which hospitalized patients may course with an adverse outcome. The aim of this study was to identify biomarkers at hospital admission associated with increased risk of death in hospitalized patients with COVID-19. Methods: Prospective study in patients with COVID-19 admitted to a hospital and followed until discharge or death. All patients underwent clinical evaluation and laboratory tests on the first day of admission. Results: 100 patients were included, with a mean age of 57 years and 19 died. The variables associated with higher mortality were age), platelet count, D-dimer and troponin. Platelet count was independently associated with mortality, with area under the curve: 0.74 [95% CI: 0.62 - 0.86; p = 0.001]. The area under the curve of D-dimer for death was 0.74 [95% CI: 0.62 - 0.86; p= 0.001]. Considering the Kaplan Meier curves for survival in the hospitalization, there was a significant difference in the curves for D-dimer cutoff point above or below 1.1 mg/L (Log-Rank, p=0.03). Conclusion: The levels of D-dimer and platelet count have good accuracy in the detection of increased risk of death in hospitalized patients with COVID-19.

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“…D-dimer levels are a reliable predictor of in-hospital mortality and correlate with disease severity (25). D-Dimer concentration may indicate the presence of concurrent PE in persons with COVID-19 infection (30). Even when other risk factors were included, D-dimer levels were connected to an increased risk of critical illness, thrombosis, acute renal injury, and all-cause mortality in COVID-19 patients (30).…”

Section: Discussionmentioning

confidence: 99%

Study of D-dimer, CRP & ferritin status as independent risk factors for severity of the clinical aspects in patients with COVID-19 in Erbil, Iraq

Agha¹,

Rezaei²,

Al-khayat³

et al. 2023

ajhs

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BACKGROUNDCoronavirus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a respiratory disease which can evolve into multi-organ failure (MOF), leading to death. Several biochemical alterations have been described in COVID-19 patients. This study aimed to look at the ratio of D-dimer, CRP (C- reactive protein), and ferritin as independent risk variables in COVID-19 illness patients in Erbil Governorate, Iraq.MATERIALS AND METHODSIn this retrospective data collection study, we aimed to determine the number of patients diagnosed with COVID-19 who were admitted to Rizgary and Komary hospitals. Moreover, we collected data, including demographic features and laboratory analysis results regarding: D-dimer, Ferritin and CRP(C- reactive protein) extracted from the patient's medical records. Patients were Erbil residents admitted to Rizgary & Komary educational hospital from 1st April to 1st November 2020, with a confirmed diagnosis of COVID-19 infection using SARS-CoV-2 viral nucleic acid using RT-PCR. CRP, D-dimer, and ferritin levels had been routinely measured on admission.RESULTSCRP, D-dimer, and ferritin levels were measured in 234 individuals (115 men and 119 women). The group aged 15-25 was the least afflicted, while the age group 45-55 had the most COVID-19 patients. The frequency of this disorder did not differ statistically significantly between men and women. According to a massive increase in CRP, men showed a far higher risk than women. In the research groups, there were no statistically significant differences in ferritin changes between males and females. In terms of D-dimer, there was no statistically significant difference between males and females in either of the studied groups.CONCLUSIONSHigher CRP levels, indicating a higher risk of disease and predicting and measuring the onset of the disease in the first few days, are mandatory in tracking COVID-19 disease.

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Relationship of D-Dimer and Prediction of Pulmonary Embolism in Hospitalized COVID-19 Patients: A Multicenter Study

Cited by 10 publications

References 30 publications

Combined Use of Wells Scores and D-dimer Levels for the Diagnosis of Deep Vein Thrombosis and Pulmonary Embolism in COVID-19: A Retrospective Cohort Study

Combined Use of Wells Scores and D-dimer Levels for the Diagnosis of Deep Vein Thrombosis and Pulmonary Embolism in COVID-19: A Retrospective Cohort Study

The role of biomarkers in the prediction of mortality in hospitalized patients for COVID-19

Study of D-dimer, CRP & ferritin status as independent risk factors for severity of the clinical aspects in patients with COVID-19 in Erbil, Iraq

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