Relationship of delay aversion and response inhibition to extinction learning, aggression, and sexual behaviour

Bergh, Filip Van den; Spronk, Marjolein; Ferreira, L.; Bloemarts, Emilie; Groenink, Lucianne; Olivier, Berend; Oosting, Ronald S.

doi:10.1016/j.bbr.2006.08.003

Cited by 35 publications

(32 citation statements)

References 61 publications

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“…Svensson et al (2000) also found that gonadectomy decreased impulsivity, and this effect was reversed in rats that received testosterone substitution after gonadectomy. Thus, two studies are in agreement that testosterone in males is related to higher levels of impulsivity; however, in a third study, there was no relationship between plasma testosterone and impulsivity in male rats (Van den Bergh et al 2006). Results from another study suggested that testosterone's effects may be baseline-dependent (Takahashi et al 2006); that is, testosterone enhanced impulsive choice in nonimpulsive men, and it decreased impulsive choice in impulsive men (Takahashi et al 2006).…”

Section: Sex and Hormonal Factorsmentioning

confidence: 78%

“…Performance on laboratory measures of impulsive choice and inhibition are not necessarily related in humans (Dalen et al 2004;Solanto et al 2001;Sonuga-Barke 2003;Sonuga-Barke et al 2003) or rats (Van den Bergh et al 2006). There are most likely individual differences in the extent to which these two manifestations of impulsivity are present.…”

Section: Operational Measures Of Impulsivitymentioning

confidence: 95%

“…In addition, these factors may be differentially related to different facets of impulsivity: impulsive choice or impaired inhibition. For example, extinction learning and aggression were both related to impulsive choice; however, neither was related to impaired inhibition (Van den Bergh et al 2006). …”

Section: Impaired Inhibitionmentioning

confidence: 96%

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The role of impulsive behavior in drug abuse

2008

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Impulsivity expressed as impulsive choice or inhibitory failure plays a role in several key transition phases of drug abuse. There is evidence to support all three nonexclusive hypotheses. Increased levels of impulsivity lead to acquisition of drug abuse (H1) and subsequent escalation or dysregulation of drug intake. Drugs of abuse may increase impulsivity (H2), which is an additional contributor to escalation/dysregulation. Abstinence, relapse, and treatment may be influenced by both H1 and H2. In addition, there is a relationship between impulsivity and other drug abuse vulnerability factors, such as sex, hormonal status, reactivity to nondrug rewards, and early environmental experiences that may impact drug intake during all phases of addiction (H3). Relating drug abuse and impulsivity in phases of addiction via these three hypotheses provides a heuristic model from which future experimental questions can be addressed.

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Section: Sex and Hormonal Factorsmentioning

confidence: 78%

Section: Operational Measures Of Impulsivitymentioning

confidence: 95%

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The role of impulsive behavior in drug abuse

2008

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“…Indirect support for a lack of effect of serotonin in the mediation of action cancellation comes from a study by van den Bergh et al (2006) who found no link in rats between aggression towards intruders and slowing of SSRT, although they did find a direct correlation between this form of aggression and another form of behavioural disinhibition, impulsive choice (delayed gratification). This indirectly supports the lack of effect of serotonin in the control of stopping because there are links between serotonin and some, although not all, forms of aggression.…”

Section: Role Of 5-ht In Action Cancellationmentioning

confidence: 99%

The neuropsychopharmacology of action inhibition: cross-species translation of the stop-signal and go/no-go tasks

2008

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Background and rationale The term 'action inhibition' encapsulates the ability to prevent any form of planned physical response. Growing evidence suggests that different 'stages' or even subtypes of action inhibition activate subtly different neuropharmacological and neuroanatomical processes. Objectives In this review, we present evidence from two commonly used and apparently similar behavioural tests, the stop-signal task and the go/no-go task, to determine if these have similar neuroanatomical and neurochemical modulation. Results Whilst performance of the stop-signal and go/no-go tasks is modulated across only subtly different anatomical networks, serotonin (5-HT) is strongly implicated in inhibitory control on the go/no-go but not the stop-signal task, whereas the stop-signal reaction time appears more sensitive to the action of noradrenaline. Conclusions There is clear neuropharmacological and neuroanatomical evidence that stop-signal and go/no-go tasks represent different forms of action inhibition. This evidence translates with remarkable consistency across species. We discuss the possible implications of this evidence with respect to the development of novel therapeutic treatments for disorders in which inhibitory deficits are prominent and debilitating.

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“…Response inhibition models assess the subject"s ability to inhibit responding [20], [21], [22], and delayed reward models measure an animal"s choice between a small, immediate reinforcer, and a large, delayed reinforcer, assessing "impulsive choice", an index of impulsivity [23], [24]. Van den Bergh et al [25] investigated the relationship between response inhibition and delay aversion in rats, suggesting that response inhibition and delay aversion are independent measures of impulsivity, consistent with previous findings in humans [18].…”

Section: Accepted M Manuscriptmentioning

confidence: 99%

Behavioural and physiological correlates of impulsivity in the domestic dog (Canis familiaris)

Wright

Mills

Pollux

2012

Physiology & Behavior

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Impulsivity is a trait related to inhibitory control which is expressed in a range of behaviours. Impulsive individuals show a decreased ability to tolerate delay of reinforcement, and more impulsive behaviour has been linked to decreased levels of serotonin and dopamine in a number of species. In domestic dogs, impulsivity is implicated in problem behaviours that result from a lack of self control, but currently there are no published studies that assess behavioural and physiological measures of impulsivity in relation to this trait. Impulsivity scores were calculated for 41 dogs using an owner-report assessment, the Dog Impulsivity Assessment Scale (DIAS).Twenty-three of these subjects completed an operant choice task based on a delayed reward paradigm, to assess their tolerance to delay of reinforcement. High Pressure Liquid Chromatography (HPLC) with Fluorometric Detection was used to detect levels of the metabolites of serotonin (5-HIAA) and dopamine (HVA) in the urine of 17 of the subjects. Higher impulsivity scores were found to be significantly correlated with more impulsive behaviour (reduced tolerance to delay of reinforcement) in the behaviour tests and lower levels of urinary 5-HIAA and 5-HIAA/HVA ratio. The results demonstrate convergent validity between impulsivity (as assessed by the DIAS) and behavioural and physiological parameters.

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Relationship of delay aversion and response inhibition to extinction learning, aggression, and sexual behaviour

Cited by 35 publications

References 61 publications

The role of impulsive behavior in drug abuse

The role of impulsive behavior in drug abuse

The neuropsychopharmacology of action inhibition: cross-species translation of the stop-signal and go/no-go tasks

Behavioural and physiological correlates of impulsivity in the domestic dog (Canis familiaris)

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