Relationship of elevated casual blood glucose level with coronary heart disease, cardiovascular disease and all-cause mortality in a representative sample of the Japanese population. NIPPON DATA80

Kadowaki, Sayaka; Okamura, Tomonori; Hozawa, Atsushi; Kadowaki, Takashi; Kadota, Aya; Murakami, Yoshitaka; Nakamura, Koshi; Saitoh, Shigeyuki; Nakamura, Yasuyuki; Hayakawa, Takehito; Kita, Yoshikuni; Okayama, Akira; Ueshima, Hirotsugu

doi:10.1007/s00125-007-0915-6

Cited by 65 publications

(59 citation statements)

References 38 publications

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“…The NIPPON DATA 80 Study indicated that DM, defined by nonfasting blood glucose levels, was a risk factor for CVD mortality. 33 In the Funagata Diabetes Study, IFG was not a risk factor Abbreviations: DM, diabetes mellitus; IFG, impaired fasting glucose. Multivariate analyses were adjusted for age, body mass index, hypertension, hyperlipidemia and smoking and drinking status.…”

Section: Discussionmentioning

confidence: 99%

The combined impact of blood pressure category and glucose abnormality on the incidence of cardiovascular diseases in a Japanese urban cohort: the Suita Study

et al. 2010

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Few prospective studies have examined the combined impact of blood pressure (BP) categories and glucose abnormalities on the incidence of cardiovascular disease (CVD) in the general Asian population. This study aimed to examine the effect of the combined risks of these factors on the incidence of CVD in a general Japanese population. We studied 5321 Japanese individuals (aged 30-79 years), without CVD at baseline, who received follow-up for an average of 11.7 years. Serum fasting glucose categories were defined according to the 2003 American Diabetes Association recommendations. BP categories were defined by the 2009 Japanese Society of Hypertension Guidelines for the Management of Hypertension. The Cox proportional hazard ratios (HRs) for CVD according to the serum glucose and BP categories were calculated. In 62 036 person-years of follow-up, we documented 364 CVD events (198 stroke and 166 coronary heart disease (CHD)). Compared with normoglycemic subjects, the multivariable HRs (95% confidence intervals (CIs)) for CVD, CHD and stroke were 1.25 (1.00-1.58), 1.46 (1.04-2.04) and 1.11 (0.81-1.52), respectively, in individuals with impaired fasting glucose (IFG), whereas these values were 2.13 (1.50-3.03), 2.28 (1.34-3.88) and 2.08 (1.29-3.35), respectively, in individuals with diabetes mellitus (DM). Compared with normoglycemic and optimal blood pressure (BP) subjects, increased risks of CVD were observed in the normoglycemic subjects with high-normal BP or hypertension, the IFG subjects with normal or higher BP, and the DM subjects regardless of BP category (P-value for interaction¼0.046). In conclusion, the high-normal BP subjects in all glucose categories and the normal BP subjects with IFG showed increased risk of CVD in this Japanese population. Further investigation of larger cohorts of DM subjects should be conducted to better understand this phenomenon.

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Section: Discussionmentioning

confidence: 99%

The combined impact of blood pressure category and glucose abnormality on the incidence of cardiovascular diseases in a Japanese urban cohort: the Suita Study

et al. 2010

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“…Baseline surveys were performed in 1980 (NIPPON DATA80) [13][14][15][16][17][18] and in 1990. [19][20][21] Detailed methods of NIPPON DATA have been described previously.…”

Section: Participants and Follow-upmentioning

confidence: 99%

“…Blood glucose levels were measured using the cupric-neocuproine method, and the values were adjusted by using the formula ((0.047 Â (glucose concentration in mg per 100 ml))À0.541) to obtain the approximate value measured by the hexokinase method, which gives levels in mmol l À1 . 18 Diabetes was defined as casual blood glucose level of 11.1 mmol l À1 or self-reported diabetes. 18 Serum albumin and total cholesterol levels were measured by a sequential autoanalyzer (SMA12/60; Technicon, Tarrytown, NY, USA) using bromocresol-green staining for albumin and the Lieberman-Burchard direct method for total cholesterol at a specific laboratory (presently the Osaka Medical Center for Health Science and Promotion).…”

Section: Biochemical and Physical Examinationsmentioning

confidence: 99%

“…18 Diabetes was defined as casual blood glucose level of 11.1 mmol l À1 or self-reported diabetes. 18 Serum albumin and total cholesterol levels were measured by a sequential autoanalyzer (SMA12/60; Technicon, Tarrytown, NY, USA) using bromocresol-green staining for albumin and the Lieberman-Burchard direct method for total cholesterol at a specific laboratory (presently the Osaka Medical Center for Health Science and Promotion).…”

Section: Biochemical and Physical Examinationsmentioning

confidence: 99%

“…The Institutional Review Board of Shiga University of Medical Science (no. [12][13][14][15][16][17][18]2000) approved the study.…”

Section: Adl Surveymentioning

confidence: 99%

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High blood pressure in middle age is associated with a future decline in activities of daily living. NIPPON DATA80

et al. 2008

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Although several studies have reported on the relation between high blood pressure (BP) and impaired activities of daily living (ADL), only a few studies have reported on the relation of high BP in middle-aged subjects with future impaired ADL. Furthermore, no studies reported an excess impaired ADL due to non-normal BP. Using ADL 1999 data, we compared data from NIPPON DATA80 survivors without impaired ADL (N ¼ 1816) with those with impaired ADL (N ¼ 75) using baseline BP information collected in 1980. We analysed participants who were aged 47-59 years at baseline. Multiple adjusted logistic regression analyses were used to estimate the risk of impaired ADL, according to baseline BP categories using Joint National Committee 7 guidelines (normal BP, prehypertension, stage 1 hypertension (HT) and stage 2 HT). Subjects who used antihypertensive medications were classified as having stage 2 HT. We calculated excess impaired ADL due to non-normal BP. Compared with normal BP categories, the adjusted odds ratio (OR) and 95% confidence interval (CI) of having impaired ADL was higher in subjects with prehypertension (OR ¼ 1.50, 95% CI: 0.55-4.09), stage 1 HT (OR ¼ 1.56, 95% CI: 0.56-4.32) and stage 2 HT (OR ¼ 2.96, 95% CI: 1.09-8.05). Non-normal BP explained 45% (33.7/75) of impaired ADL. A positive relation of BP categories with the composite end point of mortality and impaired ADL was also observed. In conclusion, controlling BP in middle age may prevent deaths and future ADL decline.

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Current literature in diabetes

2008

Diabetes Metabolism Res

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In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of diabetes/metabolism. Each bibliography is divided into 26 sections: 1 Reviews; 2 General; 3 Genetics; 4 Epidemiology; 5 Immunology; 6 Obesity; 7 Prediction and Prevention; 8 Intervention: a) General; b) Care; c) Drug Therapy; d)Economics; e) Gene therapy; f) Nursing; g) Nutrition; h) Surgery; i) Transplantation; 9 Pathology and Complications: a) General; b) Cardiovascular; c) Eye disease; d) Gestational and fetal; e) Neurological; f) Podiatrical; g) Renal; 10 Endocrinology & Metabolism; 11 Experimental Studies; 12 Diagnosis and Techniques. Within each section, articles are listed in alphabetical order with respect to author

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Relationship of elevated casual blood glucose level with coronary heart disease, cardiovascular disease and all-cause mortality in a representative sample of the Japanese population. NIPPON DATA80

Cited by 65 publications

References 38 publications

The combined impact of blood pressure category and glucose abnormality on the incidence of cardiovascular diseases in a Japanese urban cohort: the Suita Study

The combined impact of blood pressure category and glucose abnormality on the incidence of cardiovascular diseases in a Japanese urban cohort: the Suita Study

High blood pressure in middle age is associated with a future decline in activities of daily living. NIPPON DATA80

Current literature in diabetes

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