Relationship of epicardial adipose tissue with coronary artery disease, cardiovascular risk factors and patient outcomes

Merelo-Nicolás, Marta; Consuegra-Sánchez, Luciano; Pinar-Bermúdez, Eduardo; Wasniewski, Samantha; León-Allocca, Rafael A.; Ramos-Ruiz, Pablo; Abellán-Huerta, José; López-Clemente, José C.; Castillo-Moreno, Juan A.; Soria-Arcos, Federico

doi:10.1016/j.rccl.2021.12.003

Cited by 3 publications

(4 citation statements)

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“…The association between epicardial fat volume and anthropometric measurements has been established, highlighting the importance of adjusting the amount of EAT for body size. This approach is vital, as demonstrated by a robust correlation between EAT volume and body size metrics [25]. Consistent with the current echocardiographic guidelines, it is recommended to index cardiac measures to BSA, regardless of the specific echocardiographic parameter in focus [11,31].…”

Section: Study Implications and Literature Analysismentioning

confidence: 96%

“…The findings indicate a significant correlation between EATTi and oxidative stress within the epicardial adipose tissue, establishing EATTi as a potent predictor of complex CAD requiring revascularization therapy. Thus, our investigation offers a new perspective on the interplay between adipose tissue thickness and cardiac pathology, paving the way for different approaches in cardiovascular disease management and treatment strategies [1,[22][23][24][25].…”

Section: Study Implications and Literature Analysismentioning

confidence: 99%

“…The scores assigned by these observers were averaged to determine each patient's final SYNTAX score, with any significant discrepancies resolved through a re-scoring process. The scores were then categorized into low (<23), intermediate (23)(24)(25)(26)(27)(28)(29)(30)(31)(32), and high (>32) tertiles using specialized software for calculation [15]. This categorization facilitated a more detailed analysis of the correlation between the complexity of coronary artery lesions and other cardiac parameters in the study.…”

Section: The Syntax I and Ii Scoresmentioning

confidence: 99%

“…The role of EAT in cardiovascular pathology raises a crucial question: is EAT merely a marker of visceral adiposity, signaling the presence of other cardiovascular risk factors, or does it have a causal relationship with these pathologies? [25]. The pathophysiological mechanism involving the excessive production of ROS by adipocytes, a condition termed adipocyte oxidative stress, is characterized by an overabundance of ROS and diminished antioxidant defense.…”

Section: Study Implications and Literature Analysismentioning

confidence: 99%

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Assessing the Relationship between Indexed Epicardial Adipose Tissue Thickness, Oxidative Stress in Adipocytes, and Coronary Artery Disease Complexity in Open-Heart Surgery Patients

Braescu,

Sturza,

Aburel

et al. 2024

Medicina

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Background and Objectives: This cross-sectional study conducted at the Timișoara Institute of Cardiovascular Diseases, Romania, and the Centre for Translational Research and Systems Medicine from “Victor Babeș” University of Medicine and Pharmacy of Timișoara, Romania, investigated the relationship between indexed epicardial adipose tissue thickness (EATTi) and oxidative stress in epicardial adipose tissue (EAT) adipocytes in the context of coronary artery disease (CAD) among open-heart surgery patients. The objective was to elucidate the contribution of EATTi as an additional marker for complexity prediction in patients with CAD, potentially influencing clinical decision-making in surgical settings. Materials and Methods: The study included 25 patients undergoing cardiac surgery, with a mean age of 65.16 years and a body mass index of 27.61 kg/m2. Oxidative stress in EAT was assessed using the ferrous iron xylenol orange oxidation spectrophotometric assay. The patients were divided into three groups: those with valvular heart disease without CAD, patients with CAD without diabetes mellitus (DM), and patients with both CAD and DM. The CAD complexity was evaluated using the SYNTAX score. Results: The EATTi showed statistically significant elevations in the patients with both CAD and DM (mean 5.27 ± 0.67 mm/m2) compared to the CAD without DM group (mean 3.78 ± 1.05 mm/m2, p = 0.024) and the valvular disease without CAD group (mean 2.67 ± 0.83 mm/m2, p = 0.001). Patients with SYNTAX scores over 32 had significantly higher EATTi (5.27 ± 0.66 mm/m2) compared to those with lower scores. An EATTi greater than 4.15 mm/m2 predicted more complex CAD (SYNTAX score >22) with 80% sensitivity and 86% specificity. The intra- and interobserver reproducibility for the EATTi measurement were excellent (intra-class correlation coefficient 0.911, inter-class correlation coefficient 0.895). Conclusions: EATTi is significantly associated with CAD complexity in patients undergoing open-heart surgery. It serves as a reliable indicator of more intricate CAD forms, as reflected by higher SYNTAX scores. These findings highlight the clinical relevance of EATTi in pre-operative assessment, suggesting its potential utility as a prognostic marker in cardiac surgical patients.

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Section: Study Implications and Literature Analysismentioning

confidence: 96%