Relationship of epicardial fat tissue thickness with oxidant biomarkers in chronic kidney disease

Karataş, Ahmet; Çanakçı, Ebru; Bektaş, Ömer; Bayrak, Tülin; Bayrak, Ahmet; Altınbaş, Akif; Türkmen, Ercan

doi:10.4149/bll_2018_102

Cited by 10 publications

(18 citation statements)

References 18 publications

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“…Many studies have proposed an association of CKD with epicardial fat thickness (EFT). Previously increased EFT has been noted in hemodialysis patients [10].…”

Section: Introductionmentioning

confidence: 92%

The Association of Glomerular Filtration Rate With Echocardiographic Parameters in Chronic Kidney Disease

et al. 2021

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Background: Cardiovascular disease (CVD) is the primary cause of mortality and morbidity in chronic kidney disease (CKD) patients. Aortic propagation velocity (APV), epicardial fat thickness (EFT) and carotid intima-media thickness (CIMT) measurements could provide additional information on assessing renal decline in CKD patients. The study aimed to evaluate EFT, AVP and CIMT in CKD patients and then investigate the association among those parameters. Methods: A total of 170 CKD consecutive subjects were enrolled in the study. Patients were divided into five groups according to their estimated glomerular filtration rate (eGFR) values. Each patient underwent complete transthoracic echocardiography examination. APV, EFT and CIMT were measured for analyses. A multivariate linear regression model was used for analysis to determine the independent predictors of eGFR. Results: The lowest APV was observed in stage IV-V, and the highest APV was observed in stage I-II (P < 0.001). Stage IV-V patients had the highest EFT and stage I-II patients had the lowest EFT (P < 0.001). Moreover, the lowest CIMT was observed in stage III, and the highest CIMT was observed in stage V (P < 0.001). eGFR was significantly and positively correlated with APV and negatively correlated with EFT and CIMT. In multivariate analyses, APV (odds ratio (OR): 0.289, P < 0.001), EFT (OR:-0.135, P < 0.001) and CIMT (OR:-0.388, P < 0.001) were independent predictors of eGFR. Conclusion: We found that APV decreased, and EFT and CIMT increased as CKD progress. The present study suggests that APV, EFT and CIMT might be incorporated with the examination of CKD patients in daily practice.

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“…Many studies have proposed an association of CKD with epicardial fat thickness (EFT). Previously increased EFT has been noted in hemodialysis patients [10].…”

Section: Introductionmentioning

confidence: 92%

The Association of Glomerular Filtration Rate With Echocardiographic Parameters in Chronic Kidney Disease

et al. 2021

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“…In a study carried out in a cohort of more than 400 patients with CKD stage 4-5 and 5 on dialysis EF emerged as a risk factor for alterations in myocardial perfusion as well as appearance of vascular calcification ( 3 ), and was also independently associated with vascular calcification in predicting myocardial perfusion defects in this study. Karatas et al recently demonstrated that EAT thickness measured by echocardiography was significantly greater in hemodialysis patients than in those in pre-dialysis stages or in healthy subjects ( 47 ). Similarly, in a sub analysis of the RIND study (Renagel in a new dialysis trial), which initially evaluated the presence of coronary artery calcifications (CAC) and alterations in calcium and phosphorus in patients starting dialysis treatment, it was observed that each 10 cc increase in EF volume raised mortality by 6% ( 4 ).…”

Section: Organ-specific Fat As Causative Factor Of Cardiorenal Diseasementioning

confidence: 99%

Cardiorenal Fat: A Cardiovascular Risk Factor With Implications in Chronic Kidney Disease

et al. 2021

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There is a growing interest in the potential role of adipose tissues in cardiac and renal pathophysiology, and determining the mechanisms by which fat compartments around the heart and kidneys influence cardiovascular disease is of clinical importance in both general and high-risk populations. Epicardial fat and perirenal fat have been associated with adverse outcomes in chronic kidney disease (CKD) patients. Epicardial fat is a rich source of free fatty acids and is capable of secreting inflammatory and pro-atherogenic cytokines that promote atherosclerosis through a local paracrine effect. Recent evidence has demonstrated that perirenal fat has a closer correlation with kidney diseases than other visceral fat deposits in obesity or metabolic disturbances. Moreover, perirenal fat has been reported as an independent risk factor for CKD progression and even associated with cardiorenal dysfunction. Accordingly, these forms of organ-specific fat deposits may act as a connecter between vascular and cardiorenal disease. This review explores the possible links between epicardial and perirenal fat and its significant role as a modulator of cardiorenal dysfunction in CKD patients.

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“…Several studies have demonstrated that the EAT thickness is high in hemodialysis or peritoneal dialysis patients than the healthy subjects (see Table 2 [47,48,49,50,51,52,53]). In a study by Sheng et al n 120 patients with CKD and 30 healthy subjects, cardiac CT showed higher EAT volume in stage 4–5 D CKD group patients compared with the control group; however, EAT volume was similar between CKD 3 and control group [54].…”

Section: Eat In Chronic Kidney Disease (Ckd) and End-stage Renal Dmentioning

confidence: 99%

“…PON-1 is the most potent high-density lipoprotein (HDL) associated antioxidant enzyme whose activity has been demonstrated to be inversely correlated with oxidative stress and cardiovascular risk [56,57]. Apart from this, a strong correlation was observed between EAT thickness and ischemiamodified albumin (IMA) and myeloperoxidase (MPO) in hemodialysis patients; IMA is elevated in ESRD, MPO plays a role in inflammation and CVD [49]. An inverse correlation between EAT thickness and coenzyme Q10 levels was observed in hemodialysis patients as compared to matched healthy subjects in a study by Macunluoglu et al ( p < 0.05) [58].…”

Section: Eat In Chronic Kidney Disease (Ckd) and End-stage Renal Dmentioning

confidence: 99%

Epicardial Adipose Tissue and Renal Disease

Aeddula

Cheungpasitporn

Pathireddy

2019

JCM

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Epicardial adipose tissue (EAT) is derived from splanchnic mesoderm, localized anatomically between the myocardium and pericardial visceral layer, and surrounds the coronary arteries. Being a metabolically active organ, EAT secretes numerous cytokines, which moderate cardiovascular morphology and function. Through its paracrine and vasocrine secretions, EAT may play a prominent role in modulating cardiac function. EAT protects the heart in normal physiological conditions by secreting a variety of adipokines with anti-atherosclerotic properties, and in contrast, secretes inflammatory molecules in pathologic conditions that may play a dynamic role in the pathogenesis of cardiovascular diseases by promoting atherosclerosis. Considerable research has been focused on comparing the anatomical and biochemical features of EAT in healthy people, and a variety of disease conditions such as cardiovascular diseases and renal diseases. The global cardiovascular morbidity and mortality in renal disease are high, and there is a paucity of concrete evidence and societal guidelines to detect early cardiovascular disease (CVD) in this group of patients. Here we performed a clinical review on the existing evidence and knowledge on EAT in patients with renal disease, to evaluate its application as a reliable, early, noninvasive biomarker and indicator for CVD, and to assess its significance in cardiovascular risk stratification.

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Relationship of epicardial fat tissue thickness with oxidant biomarkers in chronic kidney disease

Abstract: We believe that we have introduced three novel follow-up parameters, such as: IMA, MPO, EFTT to literature for the follow-up of CKD. As the levels of IMA MPO and EFTT increase, the severity of CKD increases (Tab. 4, Fig. 1, Ref. 25).

Cited by 10 publications

References 18 publications

The Association of Glomerular Filtration Rate With Echocardiographic Parameters in Chronic Kidney Disease

The Association of Glomerular Filtration Rate With Echocardiographic Parameters in Chronic Kidney Disease

Cardiorenal Fat: A Cardiovascular Risk Factor With Implications in Chronic Kidney Disease

Epicardial Adipose Tissue and Renal Disease

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