Relationship of epicardial fat volume with coronary plaque characteristics, coronary artery calcification score, coronary stenosis, and CT-FFR for lesion-specific ischemia in patients with known or suspected coronary artery disease

Xie, Zhen; Zhu, Jing; Li, Wenjia; Liu, Luzhou; Zhuo, Kaimin; Yang, Ronghua; Hu, Fubi

doi:10.1016/j.ijcard.2021.03.052

Cited by 15 publications

(17 citation statements)

References 34 publications

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“… 29 Supporting this hypothesis, PAT is known to be distributed asymmetrically in ‘pockets’ over the myocardium 30 and studies have demonstrated that the distribution of coronary artery disease closely follows the distribution of PAT. 6 , 21 , 31 This supports the hypothesis that this highly metabolically active tissue may exert a degree of proinflammatory paracrine effects that accelerate atherosclerosis and regional inflammation with consequent localised damage. 1 , 30 …”

Section: Discussionsupporting

confidence: 69%

Pericardial adiposity is independently linked to adverse cardiovascular phenotypes: a CMR study of 42 598 UK Biobank participants

Ardissino

McCracken

Bard

et al. 2022

European Heart Journal - Cardiovascular Imaging

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Aims We evaluated independent associations of cardiovascular magnetic resonance (CMR)-measured pericardial adipose tissue (PAT) with cardiovascular structure and function and considered underlying mechanism in 42 598 UK Biobank participants. Methods and results We extracted PAT and selected CMR metrics using automated pipelines. We estimated associations of PAT with each CMR metric using linear regression adjusting for age, sex, ethnicity, deprivation, smoking, exercise, processed food intake, body mass index, diabetes, hypertension, height cholesterol, waist-to-hip ratio, impedance fat measures, and magnetic resonance imaging abdominal visceral adiposity measures. Higher PAT was independently associated with unhealthy left ventricular (LV) structure (greater wall thickness, higher LV mass, more concentric pattern of LV hypertrophy), poorer LV function (lower LV global function index, lower LV stroke volume), lower left atrial ejection fraction, and lower aortic distensibility. We used multiple mediation analysis to examine the potential mediating effect of cardiometabolic diseases and blood biomarkers (lipid profile, glycaemic control, inflammation) in the PAT-CMR relationships. Higher PAT was associated with cardiometabolic disease (hypertension, diabetes, high cholesterol), adverse serum lipids, poorer glycaemic control, and greater systemic inflammation. We identified potential mediation pathways via hypertension, adverse lipids, and inflammation markers, which overall only partially explained the PAT-CMR relationships. Conclusion We demonstrate association of PAT with unhealthy cardiovascular structure and function, independent of baseline comorbidities, vascular risk factors, inflammatory markers, and multiple non-invasive and imaging measures of obesity. Our findings support an independent role of PAT in adversely impacting cardiovascular health and highlight CMR-measured PAT as a potential novel imaging biomarker of cardiovascular risk.

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Section: Discussionsupporting

confidence: 69%

Pericardial adiposity is independently linked to adverse cardiovascular phenotypes: a CMR study of 42 598 UK Biobank participants

Ardissino

McCracken

Bard

et al. 2022

European Heart Journal - Cardiovascular Imaging

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“…Previous studies have shown that EVF is correlated with traditional risk factors of coronary heart disease [ 22 – 24 ] and positively correlated with BMI [ 25 ]. However, some research results suggest that EVF can be an independent predictor of CAD [ 26 ] and is not associated with the traditional risk factors of CAD [ 27 , 28 ]. Therefore, we analyzed the correlation between PCAT volume, BMI, and risk factors for CAD.…”

Section: Discussionmentioning

confidence: 99%

“…The data with normal distribution are described by mean ± standard deviation values and were tested with an independent-samples Student's t-test, while those with non-normal distribution are described by median (upper quartile, lower quartile) values and were tested with the Mann-Whitney U test that EVF is correlated with traditional risk factors of coronary heart disease [22][23][24] and positively correlated with BMI [25]. However, some research results suggest that EVF can be an independent predictor of CAD [26] and is not associated with the traditional risk factors of CAD [27,28]. Therefore, we analyzed the correlation between PCAT volume, BMI, and risk factors for CAD.…”

Section: Table 3 Relationship Between Pcat Volume and Cad-related Ris...mentioning

confidence: 99%

The correlation of pericoronary adipose tissue with coronary artery disease and left ventricular function

You

Wang

et al. 2022

BMC Cardiovasc Disord

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Objective We sought to investigate the correlation of pericoronary adipose tissue with coronary artery disease and left ventricular (LV) function. Methods Participants with clinically suspected coronary artery disease were enrolled. All participants underwent coronary computed tomography angiography (CCTA) and echocardiography followed by invasive coronary angiography (ICA) within 6 months. Pericoronary adipose tissue (PCAT) was extracted to analyze the correlation with the Gensini score and LV function parameters, including IVS, LVPW, LVEDD, LVESD, LVEDV, LVESV, FS, LVEF, LVM, and LVMI. The correlation between PCAT and the Gensini score was assessed using Spearman’s correlation analysis, and that between the PCAT volume or FAI and LV function parameters was determined using partial correlation analysis. Results One hundred and fifty-nine participants (mean age, 64.55 ± 10.64 years; men, 65.4% [104/159]) were included in the final analysis. Risk factors for coronary artery disease, such as hypertension, diabetes, dyslipidemia, and a history of smoking or drinking, had no significant association with PCAT (P > 0.05), and there was also no correlation between PCAT and the Gensini score. However, the LAD-FAI was positively correlated with the IVS (r = 0.203, P = 0.013), LVPW (r = 0.218, P = 0.008), LVEDD (r = 0.317, P < 0.001), LVESD (r = 0.298, P < 0.001), LVEDV (r = 0.317, P < 0.001), LVESV (r = 0.301, P < 0.001), LVM (r = 0.371, P < 0.001), and LVMI (r = 0.304, P < 0.001). Also, the LCX-FAI was positively correlated with the LVEDD (r = 0.199, P = 0.015), LVESD (r = 0.190, P = 0.021), LVEDV (r = 0.203, P = 0.013), LVESV (r = 0.197, P = 0.016), LVM (r = 0.220, P = 0.007), and LVMI (r = 0.172, P = 0.036), and the RCA-FAI was positively correlated with the LVEDD (r = 0.258, P = 0.002), LVESD (r = 0.238, P = 0.004), LVEDV (r = 0.266, P = 0.001), LVESV (r = 0.249, P = 0.002), LVM (r = 0.237, P = 0.004), and LVMI (r = 0.218, P = 0.008), respectively. Finally, the total volume was positively correlated with FS (r = 0.167, P = 0.042). Conclusion The FAI was positively correlated with the LV function but was not associated with the severity of coronary artery disease.

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“…Previous studies have shown that EVF is correlated with traditional risk factors of coronary heart disease [19][20][21] , and EVF is positively correlated with BMI [22] . However, some research results show that EVF can be an independent predictor of CAD [23] and is not associated with the traditional risk factors of CAD [24,25] . Therefore, we analyzed the correlation between PCAT volume and BMI and risk factor for CAD.…”

Section: Discussionmentioning

confidence: 99%

The Correlation of Pericoronary Adipose Tissue with Coronary artery disease and left ventricular function

You

Wang

et al. 2022

Preprint

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Objective: To investigate the correlation of pericoronary adipose tissue with coronary artery disease and left ventricular function.Methods: Participants with clinically suspected coronary artery disease were enrolled. All participants underwent coronary computed tomography angiography (CCTA) and echocardiography followed by invasive coronary angiography (ICA) within 6month. pericoronary adipose tissue (PCAT) was extracted to analyze the correlation with Gensini score and left ventricular function parameter, including IVS, LVPW, LVEDD, LVESD, LVEDV, LVESV, FS, LVEF, LVM, LVMI. The correlation between PCAT and Gensini was assessed by using Spearman correlation analysis, and between PCAT volume or FAI and left ventricular function parameters was assessed by using partial correlation analysis.Results: One hundred and fifty-nine participants (mean age, 64.55years ±10.64, male:65.4%[104/159]) were included for final analysis. The risk factors of coronary artery disease, such as hypertension, diabetes, dyslipidemia, history of smoking and drinking, had no significant association with the PCAT (P>0.05); and there is no correlation between PCAT and Gensini score. However, the LAD-FAI was positively correlated with IVS(r=0.203, P=0.013), LVPW(r=0.218, P=0.008),LVEDD(r=0.317, P＜0.001)，LVESD(r=0.298, P＜0.001), LVEDV(r=0.317, P＜0.001), LVESV(r=0.301, P＜0.001), LVM(r=0.371, P＜0.001), LVMI(r=0.304, P＜0.001). The LCX-FAI was positively correlated with LVEDD(r=0.199, P=0.015)，LVESD(r=0.190, P=0.021), LVEDV(r=0.203, P=0.013), LVESV(r=0.197, P=0.016), LVM(r=0.220, P=0.007), LVMI(r=0.172, P=0.036). The RCA-FAI was positively correlated with LVEDD(r=0.258, P=0.002)，LVESD(r=0.238, P=0.004), LVEDV(r=0.266, P=0.001), LVESV (r=0.249, P=0.002), LVM(r=0.237, P=0.004), LVMI(r=0.218, P=0.008). The total volume was positively correlated with FS (r=0.167, P=0.042).Conclusion: The FAI was positively correlated with the left ventricular function, but was not associated with the severity of coronary artery disease.

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Relationship of epicardial fat volume with coronary plaque characteristics, coronary artery calcification score, coronary stenosis, and CT-FFR for lesion-specific ischemia in patients with known or suspected coronary artery disease

Cited by 15 publications

References 34 publications

Pericardial adiposity is independently linked to adverse cardiovascular phenotypes: a CMR study of 42 598 UK Biobank participants

Pericardial adiposity is independently linked to adverse cardiovascular phenotypes: a CMR study of 42 598 UK Biobank participants

The correlation of pericoronary adipose tissue with coronary artery disease and left ventricular function

The Correlation of Pericoronary Adipose Tissue with Coronary artery disease and left ventricular function

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