Relationship of Flow Rate with Symptoms, Quality of Life and Other Clinical Parameters in Patients with LUTS Suggestive of BPH

Porru, Daniele; Bartoletti, Riccardo; Austoni, E.; Carrino, Maurizio; Gianneo, E; Melloni, D.

doi:10.1159/000049874

Cited by 9 publications

(7 citation statements)

References 18 publications

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“…Maximum flow rate has been shown to be significantly associated with symptom scores in some studies, 12,13 while other investigations have shown only weak correlations. 14,15 We searched a correlation between Q max , Q ave and ICS-BPH symptom score: a significantly inverse correlation was found only for Q max , confirming Q max as a reliable parameter to quantify subjective symptoms.…”

Section: Discussionmentioning

confidence: 89%

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Home and office uroflowmetry for evaluation of LUTS from benign prostatic enlargement

Porru

Scarpa²,

Prezioso³

et al. 2005

Prostate Cancer Prostatic Dis

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A group of 107 patients with lower urinary tract symptoms (LUTS) from benign prostatic enlargement (BPE) participated to the HOUSE Study (Home and Office Uroflowmetry Specific Evaluation). Patients received routine investigation, consisting of medical history taking, physical examination including digital rectal examination, prostate-specific antigen (PSA), assessment of symptoms listed both on the International Prostate Symptom Score and on ICS-male questionnaire. We examined the results of uroflowmetry evaluation in this population; data were analysed to observe if any circadian changes of parameters obtained with home uroflowmetry could be detected. We searched a correlation between Q max , Q ave and ICS-benign prostatic hyperplasia symptom score: a significantly inverse correlation was found only for Q max , confirming Q max as a reliable parameter to quantify subjective symptoms. When examining the multiple flow curves recorded in the same patient with home uroflowmetry, voided volume and flow time had usually higher values during night-time: the existence of circadian changes of uroflowmetry parameters in patients with LUTS from BPE was confirmed, and lower values of average and maximum flow rates during sleep hours were recorded in the same patient. In conclusion, when evaluating the natural history or treatment outcome of individual patients or group of patients in clinical trials for evaluation of BPE and LUTS, an assessment including multiple measurements may be useful and of value.

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Section: Discussionmentioning

confidence: 89%

“…Storage and voiding symptoms were analysed separately in a recent study, 15 showing that the correlation was lower for storage than for voiding symptoms.…”

Section: Discussionmentioning

confidence: 99%

Home and office uroflowmetry for evaluation of LUTS from benign prostatic enlargement

Porru

Scarpa²,

Prezioso³

et al. 2005

Prostate Cancer Prostatic Dis

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show abstract

“…The symptoms of BPH, can adversely affect different aspects of quality of life (QoL) [1][2][3][4][5] . Many men with BPH and lower urinary tract symptoms (LUTS) wait until symptoms become significantly bothersome before seeking medical attention 6 .…”

Section: Introductionmentioning

confidence: 99%

Effects of Transurethral Resection of Prostate (TURP) on Quality of Life in Case of Benign Prostatic Hyperplasia

Hossain

Alam

Naser

et al. 2019

J. Natl Inst. Neurosci Bangladesh

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Background: BPH is one of the most common cause of LUTS which significantly impairs the quality of life. TURP is minimally invasive surgical procedure for Benign Prostatic hyperplasia which has impact on quality of life. Impact on quality of life can be measured by QoL score and effect of TURP can be evaluated. Objective: The purpose of the present study was to evaluate the impact of transurethral resection of prostate (TURP) on Quality of Life (QoL) score. Methodology: This prospective study was carried out in the Department of Urology, Shaheed Suhrawardy Medical College and Hospital, Dhaka, from July 2015 to June 2016. Total fifty patients between 50 to 72 years attending for the treatment of benign prostatic hypertrophy (BPH) with lower urinary tract symptoms (LUTS) were included for the study according to inclusion & exclusion criteria. All of them were evaluated with baseline international prostate symptoms score (IPSS), QoL score, peak urinary flow rate (Qmax), voided volume, voiding time and PVR and were recorded in a predesigned data sheet. Selected patients underwent Transurethral Resection of Prostate. They were followed after 1 month and 3 months with same parameter and compared with the baseline values. Results: The baseline international prostate symptoms score (IPSS) in this study was 25.18±1.45. At one month and three months follow up visits after TURP, the IPSS was decreased to 15.0±1.07 and 8.14±0.76 respectively. There was significant improvement of peak urinary flow rate (Qmax) in the postoperative period, at the 1st follow up visit after one month of TURP (15.78±1.42, p<0.001) and at the 2nd follow visit after three months of TURP (18.78, p <0.001). The mean QoL score was 5.30±0.46 before TURP. After one month of TURP it was 3.20±0.45 and after 3 months of TURP it was 1.86±0.57. Conclusion: There is a significant improvement of quality of after TURP. Journal of National Institute of Neurosciences Bangladesh, 2019;5(2): 143-147

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“…It is well documented that LUTS are associated with a lower quality of life for both men [1,[4][5][6][7] and their partners [8,9]. Also, in the absence of complications such as acute urinary retention (AUR), symptoms and associated bother remain a major cause of referral for surgical intervention in men with BPH [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Long‐term sustained improvement in symptoms of benign prostatic hyperplasia with the dual 5α‐reductase inhibitor dutasteride: results of 4‐year studies

et al. 2005

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included a breakdown of the AUA-SI score, including stratifying patients by symptom severity, assessment by baseline age and prostate volume, and the evaluation of symptoms responders. RESULTSThere was a clinically meaningful improvement in AUA-SI in patients on dutasteride in the double-blind phase, but not in those on placebo. At 48 months, patients on dutasteride in both study phases had greater improvements in AUA-SI score and individual question scores than those on dutasteride in the open-label phase only. The proportion of patients with severe symptoms declined in both study groups, although these changes were more profound in those receiving dutasteride for the 4-year duration of the study. CONCLUSIONIn men with symptomatic benign prostatic hyperplasia, long-term (4-year) treatment with the dual isozyme 5 a -reductase inhibitor dutasteride resulted in sustained and continued improvements in symptoms and flow rate. For 4 vs 2 years, longer dutasteride therapy resulted in greater symptom improvement.

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Relationship of Flow Rate with Symptoms, Quality of Life and Other Clinical Parameters in Patients with LUTS Suggestive of BPH

Cited by 9 publications

References 18 publications

Home and office uroflowmetry for evaluation of LUTS from benign prostatic enlargement

Home and office uroflowmetry for evaluation of LUTS from benign prostatic enlargement

Effects of Transurethral Resection of Prostate (TURP) on Quality of Life in Case of Benign Prostatic Hyperplasia

Long‐term sustained improvement in symptoms of benign prostatic hyperplasia with the dual 5α‐reductase inhibitor dutasteride: results of 4‐year studies

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