Relationship of Gender, Body Mass Index, and Axial Length with Central Retinal Thickness Using Optical Coherence Tomography

Abstract

Background Optical coherence tomography (OCT) acquires cross-sectional retinal images with high resolution using low-coherence interferometry. Few studies have studied the effect of demographic data and ocular parameters that may affect central retinal thickness. In this study, these factors were used as parameters to analyse if any significant relationship exists with central retinal thickness. Methods Volunteers with a best-corrected visual acuity of 6/12 or better and no evidence of ocular abnormalities or interventions were recruited from October 2001 to March 2003. Body mass index (BMI), autorefraction, and keratometry recordings were measured, followed by applanation tonometry and Ascan ultrasonography. The central retinal thickness of the right eye was analysed using a scan length of 3 cm. Another 25 eyes were selected for interobserver reproducibility. Results In all, 117 normal subjects (60 male and 57 female subjects) were recruited. The mean thickness of the central retina with a diameter of 1 mm was 203723 mm for male and 189720 mm for female subjects. Age, intraocular pressure, and keratometric readings were not significantly correlated with central retinal thickness. Using multiple regression, gender, BMI, axial length, and signal-to-noise ratio (Po0.05) were significantly associated with the central retinal thickness. The intraclass correlation coefficient was 0.98 for interobserver reproducibility. Conclusion OCT has a high interobserver reproducibility. The male gender, larger BMI,

Influence of diabetes on macular thickness measured using optical coherence tomography: the Singapore Indian Eye Study

“…40,41 Lam et al 40 hypothesized that the thicker fovea could be a sign of early vitreoretinal traction in highly myopic eyes. Previous studies reported that women have thinner macular measurements, 13,30,38,39 which is consistent with our results. This may explain why certain macular conditions, such as macular hole, occur more frequently in women.…”

“…Lastly, macular thickness was assessed by instruments other than the OCT in some of the earlier studies, such as the retinal thickness analyzer, and these imaging modalities may not be comparable to Stratus OCT. 10,29,[35][36][37] We identified age, gender, and SE as factors that significantly affected macular measurements using Stratus OCT, which is consistent with the results of previous studies. 10,13,18,[38][39][40][41] However, our results also indicate that more myopic individuals have an increased foveal thickness but reduced macular volume, which substantiate earlier reports. 40,41 Lam et al 40 hypothesized that the thicker fovea could be a sign of early vitreoretinal traction in highly myopic eyes.…”

Retinal Nerve Fiber Layer and Macula Thickness with Spectral Domain Optical Coherence Tomography in Children: Normal Values, Repeatability and the Inflfluence of Demographic and Ocular Parameters

“…1,[3][4][5]20,21 It has been hypothesized that with increasing myopia and axial length, the thickness of the inner and outer rings of the macula is decreased due to the mechanical stretching of a similar volume of retina over a larger area. 22,23 Congruent with this hypothesis, we found significant positive correlations between outer macula thicknesses and SER, and significant negative correlations between outer macular thicknesses and AL. Similar correlations were also found by other authors.…”

Changes of macular and RNFL thicknesses measured by Stratus OCT in patients with early stage diabetes

“…16 Therefore, we compared the differences of the macular and RNFL thicknesses between men and women. In the normal participants, the macula was thinner in women than in men but the difference was not significant.…”