Influence of diabetes on macular thickness measured using optical coherence tomography: the Singapore Indian Eye Study

Sng, Chelvin C. A.; Cheung, Carol Y.; Man, Ryan Eyn Kidd; Wong, Wan Ling; Lavanya, Raghavan; Mitchell, Paul; Aung, Tin; Wong, Tien Yin

doi:10.1038/eye.2012.11

Cited by 24 publications

(22 citation statements)

References 48 publications

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“…24 Previous OCT studies have shown different results regarding retinal thickness changes in diabetes patients, as some have reported an increase, [25][26][27][28] while others have shown a decrease in the thickness of the central retina. [29][30][31][32] More recent studies report that there is a selective thinning of the inner retina, which occurs during the very early stages of DR.…”

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confidence: 99%

Retinal Nerve Fiber Layer and Ganglion Cell Complex Thicknesses Are Reduced in Children With Type 1 Diabetes With No Evidence of Vascular Retinopathy

El-Fayoumi

Eldine

Esmael

et al. 2016

Invest. Ophthalmol. Vis. Sci.

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Citation: El-Fayoumi D, Badr Eldine NM, Esmael AF, Ghalwash D, Soliman HM. Retinal nerve fiber layer and ganglion cell complex thicknesses are reduced in children with type 1 diabetes with no evidence of vascular retinopathy. Invest Ophthalmol Vis Sci. 2016;57:5355-5360. DOI: 10.1167/iovs.16-19988 PURPOSE. To determine whether type 1 diabetes (T1DM) in children with a mean age of 12.21 6 3.04 years affects the retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) when compared to age-and sex-matched healthy children.METHODS. Forty-six children with T1DM with no diabetic retinopathy (DR) and 50 normal ageand sex-matched controls underwent full clinical ophthalmic and spectral-domain optical coherence tomography (SD-OCT) examination. Using RTVue Fourier-Domain OCT (version 6.11.0.12) average, superior, and inferior RNFL and GCC thicknesses (in lm) were measured. Mean values of patients and the control group were compared. RESULTS.In children with T1DM with no DR, the mean average RNFL thickness was 110.9 lm 6 10.46, and the mean GCC thickness was 95.59 lm 6 5.13; both were significantly thinner than the control group (115.62 lm and 99.30 lm, respectively). The retinal nerve fiber layer and GCC thickness showed no correlation to either age of onset, duration of the disease, or glycosylated hemoglobin (HbA1c). A positive correlation was found between the daily insulin dose and the average RNFL thickness (r ¼ 0.378, P ¼ 0.01). The average GCC in children with dyslipidemia was thinner than those with normal lipid profile (91.29 6 6.46 lm, 97.11 6 3.59 lm, respectively) with a P value of 0.011. CONCLUSIONS.Thinning of the RNFL and GCC in children with T1DM with no DR compared to healthy controls suggests that neurodegenerative changes occur in the absence of vascular changes. It also shows that neurodegeneration is not related to either disease duration, onset, or control.

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confidence: 99%

Retinal Nerve Fiber Layer and Ganglion Cell Complex Thicknesses Are Reduced in Children With Type 1 Diabetes With No Evidence of Vascular Retinopathy

El-Fayoumi

Eldine

Esmael

et al. 2016

Invest. Ophthalmol. Vis. Sci.

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“…Other studies, which included subjects with both types of diabetes and eyes without retinal vascular changes or with mild NPDR, reported lower thickness measurements in the CSF [18,20,24], similar to values found in healthy, nondiabetic controls.…”

Section: Discussionmentioning

confidence: 91%

“…Few studies found no significant correlation betweeen RT and aging, in normal [7,21] and in diabetic subjects [6,7,8], whereas most studies have documented higher RT measurements in healthy men [19,21,22,23] and in diabetic males with mild NPDR [7,20,24]. …”

Section: Introductionmentioning

confidence: 99%

“…These findings were atributed to a neurodegenerative process in the diabetic retina, preceding vascular abnormalities [16,17]. Other studies including patients with both types of diabetes, and absence of DR or mild DR lesions, showed no differences in RT measurements between diabetics and nondiabetics [18,19,20]. Finally, thicker central maculas in subjects with mild nonproliferative diabetic retinopathy (NPDR) were reported in studies including both types of diabetic patients, suggesting the occurrence of subclinical macular edema in the initial stages of DR [6,8,9].…”

Section: Introductionmentioning

confidence: 99%

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Macular Thickness Measured by Stratus Optical Coherence Tomography in Patients with Diabetes Type 2 and Mild Nonproliferative Retinopathy without Clinical Evidence of Macular Edema

Pires

Santos²,

Nunes³

et al. 2013

Ophthalmologica

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To evaluate macular thickness in eyes with mild nonproliferative diabetic retinopathy (NPDR), patients with diabetes type 2, NPDR level 20 or 35, and without evidence of clinical macular edema underwent best-corrected visual acuity assessment, color fundus photography and Stratus optical coherence tomography. Mean center point thickness (CPT) and mean central subfield (CSF) thickness were compared with those of a healthy control population. 410 eyes/patients aged 61.2 ± 8.3 years, and with glycosylated hemoglobin of 7.9 ± 1.5% were included. Mean CPT and CSF were 186.6 ± 28.4 and 215.2 ± 25 µm, respectively, significantly increased compared to healthy subjects (p < 0.001). CSF thickness was abnormally increased in 17.6% of the patients, with values within the normal range in 79.5%, and abnormally decreased in 2.9%. CPT and CSF thickness were significantly thicker in men. No systemic factors showed a significant association. A significant increase in the macular thickness was found in eyes/patients with mild NPDR without clinical macular edema; however, only 17.6% of the eyes/patients had abnormally increased values and less than 3% abnormally decreased values.

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“…Thus, valuation of central macular thickness is important. [7][8][9] Due to lacunae in the literature in Indian population, the study was conducted to assess the changes in central macular thickness in diabetics with different stages of retinopathy and in non-diabetic controls. In each stage, macula was assessed for the presence or absence of Clinically Significant Macular Oedema (CSME).…”

Section: Introductionmentioning

confidence: 99%

Central Macular Thickness in Diabetic Retinopathy- A Comparative Study

Abrar¹,

Rastogi²,

Ansari³

2017

AIMDR

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Background: Macular oedema is one of the important signs in patients with diabetic retinopathy which progresses to complete blindness. Therefore, early diagnosis of the disease can prevent the progression of disease. Methods: This comparative study was conducted on 200 eyes of 100 diabetics and non-diabetics each. Subjects were divided into five groups according to the International Clinical Diabetic Retinopathy Disease Severity Scale. In each stage, macula was assessed for the presence or absence of Clinically Significant Macular Oedema (CSME) by using Optical Coherence Tomography (OCT) method. Results: The maximum percent of patients are present in the age group of 50-60 years. The maximum and minimum percent of patients in both the genders are diagnosed in the stage 3 and stage 4 retinopathy respectively. The mean Central Macular Thickness (CMT) in the study group was 291.0±63.0 microns and the mean CMT in the control group was 216.5±11.7 microns. Central macular thickness was seen to increase progressively with increasing stages of diabetic retinopathy. A statistically significant difference in mean CMT of controls when compared with each of the diabetic subgroups independently was observed. Conclusion: Macular thickening increased with increasing stages of diabetic retinopathy without evidence of any clinically significant macular oedema. It can be used as a good indicator to monitor such diabetic individuals.

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Influence of diabetes on macular thickness measured using optical coherence tomography: the Singapore Indian Eye Study

Cited by 24 publications

References 48 publications

Retinal Nerve Fiber Layer and Ganglion Cell Complex Thicknesses Are Reduced in Children With Type 1 Diabetes With No Evidence of Vascular Retinopathy

Retinal Nerve Fiber Layer and Ganglion Cell Complex Thicknesses Are Reduced in Children With Type 1 Diabetes With No Evidence of Vascular Retinopathy

Macular Thickness Measured by Stratus Optical Coherence Tomography in Patients with Diabetes Type 2 and Mild Nonproliferative Retinopathy without Clinical Evidence of Macular Edema

Central Macular Thickness in Diabetic Retinopathy- A Comparative Study

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