Relationship of interleukin‐8 gene polymorphisms with hepatocellular carcinoma susceptibility and pathological development

Chien, Ming Hsien; Yeh, Chao‐Bin; Li, Yi Ching; Wei, Lin-Hung; Chang, Jer‐Hwa; Peng, Yung-Hsing; Yang, Shun Fa; Kuo, Wu Hsien

doi:10.1002/jso.22037

Cited by 17 publications

(27 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…First, the hypothesis-directed approach is used to investigate func- tional SNPs in coding regions since they may dysregulate the expression of proteins (12)(13)(14)(15). Second, the indirect approach is used to select a set of htSNPs which are informative polymorphisms that best characterize the haplotype diversity of a given chromosomal region.…”

Section: Discussionmentioning

confidence: 99%

“…These htSNPs serve as markers to detect associations between a particular region and diseases, regardless of whether or not the SNPs themselves have a functional effect (27,28). Previous studies have mostly used the hypothesis-directed approach to report associations between several variants and the risk of HCC (13,14). To the best of our knowledge, this is also the first study on CIP2A and HCC susceptibility by htSNP strategy.…”

Section: Discussionmentioning

confidence: 99%

“…Chronic infections of hepatitis B virus (HBV) and hepatitis C virus (HCV), excessive alcohol consumption, tobacco smoking, aflatoxin B1 (AFB1) and diabetes are reported to be associated with an increased risk of HCC (4)(5)(6)(7)(8)(9)(10). Among these known or suspected risk factors, single nucleotide polymorphisms (SNPs) may also play a significant role in infectious and non-infectious pathways associated with HCC (11)(12)(13)(14). SNPs of oncogenes and anti-oncogenes may alter the gene expression level and are functionally associated with HCC and other forms of liver disease (15).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

HapMap-based study of CIP2A gene polymorphisms and HCC susceptibility

Wang

Dai

et al. 2012

Oncology Letters

View full text Add to dashboard Cite

Abstract. CIP2A is a human oncoprotein that inhibits PP2A and stabilizes c-myc in human malignancies. Autoantibodies to CIP2A protein have been reported to be present in higher levels in sera from patients with hepatocellular carcinoma (HCC) than in sera of healthy individuals. The CIP2A gene has been demonstrated as a potential cancer susceptibility gene. To elucidate whether common CIP2A variants are associated with HCC susceptibility, we conducted a case-control study comprising 233 cases of HCC and 280 controls matched on age, gender and ethnicity in the Chinese Han population. Two haplotype-tagging single nucleotide polymorphisms (htSNPs) (rs2278911 and rs4855656) from the HapMap database were analyzed, which provide an almost complete coverage of the genetic variations in the CIP2A gene. We found that neither of these htSNPs and haplotypes were associated with the risk of HCC. However, an interaction was observed between hepatitis virus B and C infection (HBV and HCV) and the C carriers (TC or CC) of rs2278911 on HCC risk (OR=12.35; 95% CI,. No such association was found for rs4855656. Our study also demonstrated that two htSNPs (rs2278911 and rs4855656) in the CIP2A gene are not associated with the risk of HCC. HBV and HCV infection was found to exert a synergistic effect on the risk of HCC in individuals with the C carriers (TC or CC) of rs2278911 in the Chinese Han population.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

HapMap-based study of CIP2A gene polymorphisms and HCC susceptibility

Wang

Dai

et al. 2012

Oncology Letters

View full text Add to dashboard Cite

show abstract

“…, 2005). IL8 SNPs are associated with susceptibility to hepatocellular carcinoma in the Taiwanese population (Chien et al. , 2011).…”

Section: Introductionmentioning

confidence: 99%

Association between a promoter polymorphism (rs2192752, –1028A/C) of interleukin 1 receptor, type I (IL1R1) and location of papillary thyroid carcinoma in a Korean population

Park

Kim

Kwon

et al. 2012

Int J Immunogenetics

View full text Add to dashboard Cite

The interleukin 1 receptor, type I (IL1R1) is important in the pathogenesis of cancer. We investigated whether single nucleotide polymorphisms (SNPs) of IL1R1 contribute to the development of papillary thyroid carcinoma (PTC), in addition to the clinicopathological features such as the size, number, location, extrathyroidal invasion and metastasis of PTC. Three promoter SNPs (rs949963 -615G/A, rs2192752 -1028A/C and rs3917225 -1099A/G) in IL1R1 were genotyped using direct sequencing in 118 patients with PTC and 347 controls. The odds ratio (OR), 95% confidence interval (CI) and P value were analysed using SNPStats and SNPAnalyzer Pro. For the exact results, Fisher's exact test and Bonferroni correction (P(c)) were performed. The three promoter SNPs of IL1R1 were not associated with PTC development. For the clinicopathological features of PTC, rs2192752 was associated with location (one lobe versus both lobes): dominant model, OR = 3.11, 95% CI = 1.39-6.96, P(c) = 0.015; log-additive model, OR = 2.79, 95% CI = 1.38-5.66, P(c) = 0.0087. The C allele frequency of rs2192752 was higher in the both lobes group (28.0%) than the one lobe group (12.3%) (OR = 2.77, 95% CI = 1.40-5.48, P(c) = 0.009). However, rs949963 and rs3917225 were not correlated with clinicopathological features including location of PTC. The IL1R1 promoter SNP rs2192752 may contribute to the location of PTC, and the C allele of rs2192752 may be a risk factor for the development of PTC in both lobes.

show abstract

“…The Chemotactic cytokines IL-8, an angiogenic chemokine with roles in development and progression of many cancers (Chien, Yeh, Li, Wei, Chang, et al 2011) was expressed in two samples #21 and #25 ( Figure 3I). MCP-1 (CCL2), a member of the CC chemokine family that regulates monocyte migration by enhancing transit from the bone marrow into the circulation or from circulation to the site of inflammation (Tsou, Peters, Si, Slaymaker, Aslanian, et al 2007), was expressed by #21 ( Figure 3J).…”

Section: Chemotactic Factors Were Rarely Expressed By Ossn and Pterygiamentioning

confidence: 99%

Cytokine and Chemokine Expression Profiles in HIV-1 Infected Patients with Ocular Surface Squamous Neoplasia from Botswana

Simbiri¹,

Jha²,

Dzeng³

et al. 2012

CCO

View full text Add to dashboard Cite

Purpose: Ocular surface squamous neoplasia (OSSN) rate has increased in incidence with the HIV pandemic in Africa. Multiple factors including cellular and environmental can affect the pathogenesis of OSSN in HIV-infected patients. We will investigate anti-inflammatory cytokines, proinflammatory cytokines, and growth factor expression in sera and tissue samples of OSSN and pterygia for the potential link to the development of OSSN. Results: Antibody analysis showed significant changes in levels of pro-inflammatory cytokines, anti-inflammatory cytokines and growth factors in sera. Quantitative RT-PCR of tissues showed expression of inflammatory cytokines and chemokines associated with HIV infection and carcinogenesis. Conclusion: Our findings showed that dysregulation in expression of cytokines and growth factors in patients with multiple infections may contribute to pathogenesis of OSSN and pterygia. The data reinforces the significance of in depth analysis of immune function in HIV-1 OSSN patients with multiple viral infections that has potential for therapy and vaccine development.

show abstract

Relationship of interleukin‐8 gene polymorphisms with hepatocellular carcinoma susceptibility and pathological development

Abstract: Genetic polymorphism at IL-8 +781 is an important factor in determining susceptibility to HCC in the Taiwanese population.

Cited by 17 publications

References 51 publications

HapMap-based study of CIP2A gene polymorphisms and HCC susceptibility

HapMap-based study of CIP2A gene polymorphisms and HCC susceptibility

Association between a promoter polymorphism (rs2192752, –1028A/C) of interleukin 1 receptor, type I (IL1R1) and location of papillary thyroid carcinoma in a Korean population

Cytokine and Chemokine Expression Profiles in HIV-1 Infected Patients with Ocular Surface Squamous Neoplasia from Botswana

Contact Info

Product

Resources

About