2005
DOI: 10.1161/01.cir.0000153356.72810.97
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Relationship of Late Loss in Lumen Diameter to Coronary Restenosis in Sirolimus-Eluting Stents

Abstract: Background-Observed rates of restenosis after drug-eluting stenting are low (Ͻ10%). Identification of a reliable and powerful angiographic end point will be useful in future trials. Methods and Results-Late loss (postprocedural minimum lumen diameter minus 8-month minimum lumen diameter) was measured in the angiographic cohorts of the SIRIUS (nϭ703) and E-SIRIUS (nϭ308) trials. Two techniques, the standard normal approximation and an optimized power transformation, were used to predict binary angiographic rest… Show more

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Cited by 99 publications
(51 citation statements)
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“…8,9 In this study we tested the robustness of late loss by considering its reproducibility within different stent systems under a variety of clinical trial conditions. Our findings demonstrate the robustness of late loss in terms of high intraclass correlation under the various reported clinical trials.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…8,9 In this study we tested the robustness of late loss by considering its reproducibility within different stent systems under a variety of clinical trial conditions. Our findings demonstrate the robustness of late loss in terms of high intraclass correlation under the various reported clinical trials.…”
Section: Discussionmentioning
confidence: 99%
“…7 The mean in-stent late loss observed in a study can be used to predict restenosis risk for bare-metal and drug-eluting stents. 8,9 We sought to determine whether mean late loss was more stable for stent systems across studies and thus superior to observed clinical restenosis rates for distinguishing drugeluting stent performance.…”
mentioning
confidence: 99%
“…11 We investigated correlations between baseline circulating angiogenic cells and late-loss at 8 months. CXCR4+ cells, considered to maintain the pool of progenitor cells in response to various injuries, showed a significant negative correlation with the 8-month late-loss.…”
Section: Discussionmentioning
confidence: 99%
“…Late-loss, defined as the difference in millimeters between the minimal lumen diameter (MLD) at the completion of the procedure and at angiographic follow up, is commonly used to quantify the degree of accumulation of tissue. 11 Some have guessed that in-stent late-loss might serve as a useful marker of the biological activity of drug-eluting stents, with the consequence clearly being that "less is better". 12 In the era of drug-eluting stents, the significance and relationship of the traditional angiographic indexes of restenosis, especially late-loss, to clinical outcomes has yet to be defined and predicted.…”
mentioning
confidence: 99%
“…However, the distribution curves for late lumen loss after DES implantation do not follow a normal distribution but instead become progressively rightward skewed at lower levels of late loss approaching zero. 4,5 Furthermore, such a high incidence (Ϸ50%) of negative late loss has not been observed in most of the large angiographic studies involving first-generation DES, and such a high rate of positive remodeling has not been reported from intravascular ultrasound substudies. Calculations of negative late loss likely represent the known errors in quantitative measurement from serial angiograms in which the measurement error exceeds the mean value for late loss rather than a systematic gain in lumen diameter after DES.…”
Section: To the Editormentioning
confidence: 99%