Relationship of Obesity to Serum Triglyceride, Cholesterol, and Uric Acid, and to Plasma-Glucose Levels

Hollister, Leo E.; Overall, John E.; Snow, Harold L.

doi:10.1093/ajcn/20.7.777

Cited by 65 publications

(27 citation statements)

References 18 publications

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“…Recent studies have also confirmed a positive correlation between the serum urate concentration and body weight, both in Caucasians [59,67,75] and in Polynesians, recognized as a group with a tendency towards hyperuricaemia [43]. The normal range of urate production has also been defined in relation to surface area [100], implying thereby that urate production is greater in obese subjects.…”

Section: Obesitymentioning

confidence: 85%

Abnormal Renal Urate Homeostasis in Systemic Disorders

Emmerson

Ravenscroft

1975

Nephron

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Abnormalities of renal handling of urate occur in a wide variety of physiological and pathological conditions and are mediated by factors including renal blood flow, glomerular filtration rate, urine flow rate, urinary constituents, metabolites, hormones and drugs. The determination of the aetiological factors in each abnormal situation is complex and the problem is discussed in relation to a variety of conditions including renal tubular disorders and metal intoxications, hypertension, toxaemia of pregnancy, glycogen storage disease, fructose administration, hereditary fructose intolerance, as well as obesity, regular alcohol consumption and hyperlipoproteinaemia. Apart from those diseases, usually genetically determined, which are associated with excessive production of urate, the most common causes of hyperuricaemia act at a renal level and result in a reduction in the net renal excretion of urate.

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Section: Obesitymentioning

confidence: 85%

Abnormal Renal Urate Homeostasis in Systemic Disorders

Emmerson

Ravenscroft

1975

Nephron

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“…Numerous epidemiological studies have shown a positive correlation between body weight and serum uric acid levels (31,32). Recently, it was reported in a cross-sectional study that serum uric acid levels were associated with visceral fat accumulation (33).…”

Section: T a B L E 3 S T E P Wi S E Mu L T I P L E Re G R E S S I Omentioning

confidence: 99%

Relationship between the Serum Uric Acid Level, Visceral Fat Accumulation and Serum Adiponectin Concentration in Japanese Men

et al. 2008

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“…Several studies indicated that hyperuricemia was closely associated with obesity and obesity-related metabolic disorders, including hyperglycemia/insulin resistance (Rathmann et al, 1998;Lin et al, 2008), hyperlipidemia (Roux et al, 1972;Barats and Smolenskaia, 1990;Nakamura, 1996), and hypertension (Hollister et al, 1967;Oyama et al, 2006;Cho et al, 2008;Basen-Engquist and Chang, 2011;Hsu et al, 2011). Higher odds ratios (ORs) for hyperuricemia were observed in Taiwan-born Han Chinese than in U.S. individuals within the same body mass index (BMI) range (Pan et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Gender, Body Mass Index, and PPARγ Polymorphism Are Good Indicators in Hyperuricemia Prediction for Han Chinese

Lee

Liou²,

Wang³

et al. 2013

Genetic Testing and Molecular Biomarkers

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Hyperuricemia is closely associated with obesity and metabolic abnormalities, which is also an independent risk factor for cardiovascular diseases. The PPARg gene, which is linked to obesity and metabolic abnormalities in Han Chinese, might be considered a top candidate gene that is involved in hyperuricemia. This study recruited 457 participants, aged 20-40 years old, to investigate the associations of the PPARg gene and metabolic parameters with hyperuricemia. Three tag-single nucleotide polymorphisms, rs2292101, rs4684846, and rs1822825, of the PPARg gene were selected to explore their association with hyperuricemia. Risk genotypes on rs1822825 of the PPARg gene exhibited statistical significance with hyperuricemia (odds ratio: 1.9; 95% confidence interval: 1.05-3.57). Although gender, body mass index (BMI), serum total cholesterol concentration, or protein intake per day were statistically associated with hyperuricemia, the combination of BMI, gender, and rs1822825, rather than that of age, serum lipid profile, blood pressure, and protein intake per day, satisfied the predictability for hyperuricemia (sensitivity: 69.3%; specificity: 83.7%) in Taiwan-born obese Han Chinese. BMI, gender, and the rs1822825 polymorphism in the PPARg gene appeared good biomarkers in hyperuricemia; therefore, these powerful indicators may be included in the prediction of hyperuricemia to increase the accuracy of the analysis.

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Relationship of Obesity to Serum Triglyceride, Cholesterol, and Uric Acid, and to Plasma-Glucose Levels

Cited by 65 publications

References 18 publications

Abnormal Renal Urate Homeostasis in Systemic Disorders

Abnormal Renal Urate Homeostasis in Systemic Disorders

Relationship between the Serum Uric Acid Level, Visceral Fat Accumulation and Serum Adiponectin Concentration in Japanese Men

Gender, Body Mass Index, and PPARγ Polymorphism Are Good Indicators in Hyperuricemia Prediction for Han Chinese

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