Relationship of Oxidative Stress with HIV Disease Progression in HIV/HCV Co-infected and HIV Mono-infected Adults in Miami

Shin, Dong‐Ho; Martínez, Sabrina Sales; Parsons, Mary; Jayaweera, Dushyantha; Campa, Adriana; Baum, Marianna K.

doi:10.7763/ijbbb.2012.v2.104

Cited by 20 publications

(21 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…HIV uses nutrients, especially micronutrients (vitamins and minerals) in the body for its replication [1]. This causes long-term metabolic disorder [2].…”

Section: Introductionmentioning

confidence: 99%

25 (OH) Vitamin D level and Calcium/Phosphorus Metabolism Disorders in Patients Living with HIV in Abidjan

Boyvin¹,

Aké²,

Séri³

et al. 2017

IJBCRR

View full text Add to dashboard Cite

show abstract

“…HIV uses nutrients, especially micronutrients (vitamins and minerals) in the body for its replication [1]. This causes long-term metabolic disorder [2].…”

Section: Introductionmentioning

confidence: 99%

25 (OH) Vitamin D level and Calcium/Phosphorus Metabolism Disorders in Patients Living with HIV in Abidjan

Boyvin¹,

Aké²,

Séri³

et al. 2017

IJBCRR

View full text Add to dashboard Cite

show abstract

“…25 The role of oxidative stress in the pathogenesis of infections and weakened immune system are the area of research that has recently gained momentum. So it is reasonable to assume that presence of a driveline, long-term exposure to high shear stress flow environment as well as artificial blood contacting materials in CF-VADs may have an additive role in accelerating oxidative stress and weakened immune system and infection.…”

Section: Discussionmentioning

confidence: 99%

Infection, Oxidative Stress, and Changes in Circulating Regulatory T Cells of Heart Failure Patients Supported by Continuous-Flow Ventricular Assist Devices

Mondal

Sobieski

Pham³

et al. 2017

ASAIO Journal

View full text Add to dashboard Cite

The objective of this study was to investigate the changes in oxidative stress (OS) and circulating regulatory T cells (Tregs) of the immune system in CF-VAD patients with or without infection. We recruited 16 CF-VAD patients (5 with infection and 11 without infection) and 7 healthy volunteers. Generation of reactive oxygen species (ROS) from lymphocytes, superoxide dismutase (SOD) in erythrocyte, total antioxidant capacity (TAC) and oxidized low density lipoprotein (oxLDL) in plasma were measured. Circulating Tregs were evaluated by flow cytometry. HF patients had elevated OS than healthy volunteers as evident from higher lymphocyte ROS, elevated oxLDL as well as depleted SOD and TAC levels. At baseline, HF patients had decreased % of Tregs (5.12±1.5 vs. 8.14±3.01%, p<0.01) when compared to healthy volunteers. Post-implant patients with infection illustrated 35% and 44% rise in ROS and oxLDL respectively, 31% decrease in TAC and marked rise in % of Tregs (14.27±3.17 vs.9.38± 3.41%, p<0.01) when compared to the patients without infection. Elevated OS and rise in Tregs were more prominent in CF-VAD patients with infection. In conclusion, OS and compromised immune system may be important indicators of systemic response of the body to CF-VAD among HF patients with infection.

show abstract

“…Similar interaction between oxidative stress and HIV replication has been observed in clinical samples. For example, compared to HIV-infected patients, in HIV/HCV co-infected patients, higher HIV replication was observed in association with diminished antioxidant capacity to counter the oxidative stress ( Shin et al, 2012 ). Likewise, daily supplements of vitamins C and E to HIV patients resulted in reduced levels of markers for oxidative stress and a trend toward decreased viral load ( Allard et al, 1998 ).…”

Section: Smoking and Hivmentioning

confidence: 99%

Polycyclic aromatic hydrocarbons and cytochrome P450 in HIV pathogenesis

Rao

Kumar

2015

Front. Microbiol.

View full text Add to dashboard Cite

High prevalence of cigarette smoking in HIV patients is associated with increased HIV pathogenesis and disease progression. While the effect of smoking on the occurrence of lung cancer has been studied extensively, the association between smoking and HIV pathogenesis is poorly studied. We have recently shown the possible role of cytochrome P450 (CYP) in smoking/nicotine-mediated viral replication. In this review, we focus on the potential role of CYP pathway in polycyclic aromatic hydrocarbons (PAH), important constituents of cigarette smoke, mediated HIV pathogenesis. More specifically, we will discuss the role of CYP1A1 and CYP1B1, which are the major PAH-activating CYP enzymes. Our results have shown that treatment with cigarette smoke condensate (CSC) increases viral replication in HIV-infected macrophages. CSC contains PAH, which are known to be activated by CYP1A1 and CYP1B1 into procarcinogens/toxic metabolites. The expression of these CYPs is regulated by aryl hydrocarbon receptors (AHR), the cellular target of PAH, and an important player in various diseases including cancer. We propose that PAH/AHR-mediated CYP pathway is a novel target to develop new interventions for HIV positive smokers.

show abstract

Relationship of Oxidative Stress with HIV Disease Progression in HIV/HCV Co-infected and HIV Mono-infected Adults in Miami

Cited by 20 publications

References 44 publications

25 (OH) Vitamin D level and Calcium/Phosphorus Metabolism Disorders in Patients Living with HIV in Abidjan

25 (OH) Vitamin D level and Calcium/Phosphorus Metabolism Disorders in Patients Living with HIV in Abidjan

Infection, Oxidative Stress, and Changes in Circulating Regulatory T Cells of Heart Failure Patients Supported by Continuous-Flow Ventricular Assist Devices

Polycyclic aromatic hydrocarbons and cytochrome P450 in HIV pathogenesis

Contact Info

Product

Resources

About