Relationship of Plasma Interleukin-6 and Its Genetic Variants With Hypertension in Hong Kong Chinese

Abstract

The SNP rs1800796 affected plasma IL6 with a small effect size. Elevated plasma IL6 is associated with prevalent hypertension in women, but not incident hypertension.

Overweight, adipocytokines and hypertension

“…This suggests that inflammation does not play a direct role in the early development of hypertension [41], and that the elevated CRP levels at baseline in hypertensive individuals are related to overweight-induced inflammation and other potential confounders [22,42]. But this finding does not exclude that inflammation may play a role in the progression of hypertension and related diseases [43].…”

A single nucleotide polymorphism of interleukin‐6 gene is related to plasma adrenomedullin levels

“…Determining the sequence of elevation in IL‐6 and ADM levels might shed light on the causal relationship between IL‐6 and ADM and help to understand the regulation of inflammation. Interestingly, rs17147230 was associated with ADM but not IL‐6 levels; the latter was associated with another IL6 SNP rs1800796 in our previous study . Therefore, studying the interaction between the two SNPs may help understand the mechanism of the regulation of ADM level by IL‐6 .…”

“…Tagging SNPs in IL6 were selected from the HapMap Han Chinese (phase II data, release 24) as described previously . Four tagging SNPs could capture all six SNPs from the 5kb region upstream to 2kb downstream region of the gene.…”

Novel Immune Mechanisms in Hypertension and Cardiovascular Risk

“…This is also supported by the fact that polymorphisms of TNF-α and IL-6 are associated with human HT [122, 123]. …”