Relationship of Pyridoxine to Immunological Phenomena

Immune System in Uremia

“…Evidence that vitamin Be deficiency causes disturbances in cellular and humoral immunity has emerged from several studies [1][2][3]6,12,18,41], Restoration of vitamin Be in uremics resulted in the partial recovery of lymphocyte reactivity [11].…”

Biochemical deficiency of pyridoxine does not affect interleukin-2 production of lymphocytes from patients with Sjögren's syndrome

“…In a group of elderly patients, Meydani et al (1991) showed that pyridoxine deficiency reduced the mitogenic response to PHA and Con A as well as the IL-2 production of peripheral mononuclear cells and that supplementation with the vitamin reverted these alterations. The possible mechanism for the effect of vitamin B 6 on IL-production is not known, but a deficiency of this vitamin has been shown to alter the percentage of T helper cells (Van den Berg et al, 1998) and the synthesis of DNA and RNA (Axelrod & Trakatellis, 1964), which would indirectly affect IL-2 production. Also, in elderly subjects, pyridoxine supplementation has been shown to increase production of T helper lymphocytes (Talbott et al, 1987).…”

Effect of Vitamin B₆ and B₁ Deficiencies on the Intestinal Uptake of Calcium, Zinc and Cadmium

“…The lack of pyridoxine may result in an impairment of nucleic acid synthesis, with consequent inhibition of protein synthesis, cell division and repair [3], It is well known that vitamin B6, as the coenzyme, is involved in the catalysis of a wide variety of enzymatic reactions almost entirely concerned with ni trogen metabolism [25], Thus it is quite probable that a marked alteration could be expected in the brush border membrane which may lead to such a non-specific in crease in the metal ion uptake. Similarly, although thiamine occupies a central role in the intermediary metabolism of living organ isms.…”